The cadmium-resistant gene, CAD2, which is a mutated putative copper-transporter gene (PCA1), controls the intracellular cadmium-level in the yeast S. cerevisiae

Current Genetics

Volumn 37, Issue 2, 2000, Pages 79-86

  Shiraishi, Emi ^a   Inouhe, Masahiro ^a   Joho, Masanori ^a   Tohoyama, Hiroshi ^a  

^a EHIME UNIVERSITY   (Japan)

Author keywords

CAD2; Cadmium resistance; Cadmium transporter; Intracellular cadmium level

Indexed keywords

CADMIUM;

ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE MUTATION; GENE OVEREXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0034062984     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050013     Document Type: Article

References (39)

1. Askwith C, Eide D, Ho AV, Bernard PS, Li L, Davis-Kaplan S, Sipe DM, Kaplan J (1994) The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76: 403-410
2. Botstein D, Falco SC, Stewart SE, Brennan M, Scherer S, Stinchcomb DT, Struhl K, Davis RW (1979) Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene 8: 17-24
3. Broach JR, Strathern JN, Hicks JB (1979) Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene. Gene 8: 121-133
4. 2+ ATPase in Saccharomyces cerevisiae. Mol Cell Biol 16: 2226-2237
5. Dancis A, Yuan DS, Haile D, Askwith C, Eide D, Moehle C, Kaplan J, Klausner RD (1994a) Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 76: 393-402
6. Dancis A, Haile D, Yuan DS, Klausner RD (1994b) The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem 269: 25660-25667
7. Farcasanu IC, Mizunuma M, Hirata D, Miyakawa T (1998) Involvement of histidine permease (Hip1) in manganese transport in Saccharomyces cerevisiae. Mol Gen Genet 259: 541-548
8. Fogel S, Welch JW (1982) Tandem gene amplification mediates copper resistance in yeast. Proc Natl Acad Sci USA 79: 5342-5346
9. Fürst P, Hu S, Hacken R, Hamer D (1988) Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55: 705-717
10. Gaber RF, Kielland-Brandt MC, Fink GR (1990) HOLI mutations confer novel ion transport in Saccharomyces cerevisiae. Mol Cell Biol 10: 643-652
11. Gadd GM (1993) Interactions of fungi with toxic metals. New Phytol 124: 25-60
12. Gitan RS, Luo H, Rodgers J, Broderius M, Eide D (1998) Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J Biol Chem 273: 28617-28624
13. Grill E, Winnaker EL, Zenk MH (1985) Phytochelatins: the principal heavy metal complexing peptides of higher plants. Science 230: 674-676
14. Inoue H, Nojima H, Okayama H (1990) High efficiency transformation of Escherichia coli with plasmids. Gene 96: 23-28
15. Inouhe M, Inagawa A, Morita M, Tohoyama H, Joho M, Murayama T (1991) Native cadmium-metallothionein from the yeast Saccharomyces cerevisiae: its primary structure and function in heavy metal resistance. Plant Cell Physiol 32: 475-482
16. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168
17. Kägi JHR, Kojima Y (1987) Chemistry and biochemistry of metallothionein. In: Kägi JHR. Kojima Y (eds) Metallothionein II. Experientia Suppl (1987). Birkhauser Verlag, Basel, pp 25-61
18. Kyte J, Doolittle RF (1982) A simple method of displaying the hydropathic character of a protein. J Mol Biol 157: 105-132
19. Li ZS, Lu YP, Zhen RG, Szczypka M, Thiele DJ, Rea PA (1996) A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1 - catalyzed transport of bis (gulutathionato) cadmium. Proc Natl Acad Sci USA 94: 42-47
20. Liu XF, Culotta VC (1999) Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene. J Biol Chem 274: 4863-4868
21. Maniatis T, Fritsch EF, SamBrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
22. Murasugi A, Wada C, Hayashi Y (1981) Cadmium-binding peptide induced in the fission yeast. Schizosaccharomyces pombe. J Biochem 90: 1561-1564
23. Murasugi A, Wada-Nakagawa C, Hayashi Y (1984) Formation of cadmium-binding peptide allomorphs in the fission yeast. J Biochem 96: 1375 - 1379
24. Ooi CE, Rabinovich E, Dancis A, Bonifacino JS, Klausner RD (1996) Copper-dependent degradation of the Saccharomyces cerevisiae plasma-membrane copper transporter Ctr1p in the apparent absence of endocytosis. EMBO J 15: 3515-3523
25. 2+ exchangers. Mol Cell Biol 16: 3730-3741
26. Pozo LD, Osaha L, Corchero J, Jimenez A (1999) A single nucleotide change in the MNR1 (VCX1/HUM1) gene determines resistance to manganese in Saccharomyces cerevisiae. Yeast 15: 371-375
27. 2+ -transporting ATPase gene on chromosome II of Saccharomyces cerevisiae. Yeast 10: 1217-1225
28. Rose MD, Novick P, Thomas JH, Botstein D, Fink GR (1987) A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 60: 237-243
29. Sewell AK, Yokoya F, Yu W, Miyagawa T, Murayama T, Winge DR (1995) Mutated yeast heat-shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance. J Biol Chem 270: 25079-25086
30. Silar P, Butler G, Thiele DJ (1991 ) Heat-shock transcription factor activates transcription of the yeast metallothionein gene. Mol Cell Biol 11: 1232-1238
31. Silver S (1996) Bacterial resistances to toxic metal ions. Gene 179: 9-19
32. Szczypka MS, Wemmie JA, Moye-Rowley WS, Thiele DJ (1994) A yeast metal resistance protein similar to Human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269: 22853-22857
33. Thiele DJ (1988) ACEI regulates expression of the Saccharomyces cerevisiae metallothionein gene. Mol Cell Biol 8: 2745-2752
34. Tohoyama H, Inouhe M, Joho M, Murayama T (1990) Resistance to cadmium is under the control of the CAD2 gene in the yeast Saccharomyces cerevisiae. Curr Genet 18: 181-185
35. Tohoyama H, Tomoyasu T, Inouhe M, Joho M, Murayama T (1992) The gene for cadmium metallothionein from a cadmium-resistant yeast appears to be identical to CUP1 in a copper-resistant strain. Curr Genet 21: 275-280
36. Winge DR, Nielson KB, Gray WR, Hamer DH (1985) Yeast metallothionein sequence and metal-binding properties. J Biol Chem 260: 14464-14470
37. Wright MB, Howell EA, Gaber RF (1996) Amino-acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae. J Bacteriol 178: 7197-7205
38. Yang W, Gahl W, Hamer D (1991) Role of the heat-shock transcription factor in yeast metallothionein gene expression. Mol Cell Biol 11: 3676-3681
39. Zhao H, Eide D (1996) The yeast ZRT1 gene encodes the zinc-transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci USA 93: 2454-2458