The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid

British Journal of Clinical Pharmacology

Volumn 49, Issue SUPPL. 1, 2000, Pages 57-60

  Wilner, K D ^a   Hansen, R A ^a   Folger, C J ^a   Geoffroy, P ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b MDS Inc   (Canada)

Author keywords

Aluminium; Cimetidine; Interaction; Magnesium; Pharmacokinetics; Ziprasidone

Indexed keywords

ALUMINUM MAGNESIUM HYDROXIDE; ANTACID AGENT; CIMETIDINE; CYTOCHROME P450; ZIPRASIDONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0034061640     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00154.x     Document Type: Article

References (6)

1. Wilner KD, Tensfeldt TG, Baris B, et al. Single- and multiple-dose pharmacokinetics of ziprasidone in healthy young and elderly volunteers. Br J Clin Pharmacol 2000; 49(Suppl. 1): 15S-20S.
2. Prakesh C, Kamel A, Cui D, et al. Identification of the major human liver cytochrome P450 isoform responsible for the primary metabolites of ziprasidone and prediction of possible drug interactions. Br J Clin Pharmacol 2000; 49(Suppl. 1): 35S-42S.
3. Lebel M, Proulx MJ, Allard S, et al. Influence of a high fat breakfast on the absorption and pharmacokinetics of CP-88,059, a new antipsychotic. Clin Invest Med 1993; 16: B18, Abstract 117.
4. Knodell RG, Browne DG, Gwozdz GP, et al. Differential inhibition of individual human liver cytochrome P450 by cimetidine. Gastroenterology 1991; 101: 1680-1691.
5. Metropolitan height and weight tables. Stat Bull Metrop Life Found 1983; 64: 3-9.
6. Janiszewski JS, Fouda HG, Cole RO. Development and validation of a high-sensitivity assay for an antipsychotic agent, CP-88,059, with solid-phase extraction and narrow-bore high-performance liquid chromatography. J Chromatogr 1995; 668: 133-139.