T cells and fibroblasts in affected extraocular muscles in early and late thyroid associated ophthalmopathy

British Journal of Ophthalmology

Volumn 84, Issue 5, 2000, Pages 517-522

  Pappa, Anastasia ^a   Lawson, Joanna M M ^a,b   Calder, Virginia ^a   Fells, Peter ^b   Lightman, Susan ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AVIDIN; BIOTIN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL STRUCTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRAOCULAR MUSCLE; EYE DISEASE; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MUSCLE BIOPSY; MUSCLE CELL; PRIORITY JOURNAL; T LYMPHOCYTE; THYROID DISEASE;

ADULT; AGED; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; FEMALE; FIBROBLASTS; GRAVES DISEASE; HLA-DR ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; OCULOMOTOR MUSCLES; T-LYMPHOCYTE SUBSETS;

EID: 0034060969     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.84.5.517     Document Type: Article

References (30)

1. Fells P. Thyroid-associated eye disease: clinical management. Lancet 1991;338:29-32.
2. Jacobson DH, Gorman CA. Endocrine ophthalmopathy: current ideas concerning etiology, pathogenesis, and treatment. Endocr Rev 1984;5:200-20.
3. Wall JR, Salvi M, Bernard NF, et al. Thyroid-associated ophthalmopathy - a model for the association of organ-specific autoimmune disorders. Immunol Today 1991;12: 150-3.
4. Weetman AP. Thyroid-associated eye disease: pathophysiology. Lancet 1991;338:25-8.
5. Bahn RS, Smith TJ, Gorman CA. The central role of the fibroblast in the pathogenesis of extrathyroidal manifestations of Graves' disease. Acta Endocrinol (Copenh) 1989; 121:75-81.
6. Perros P, Kendall-Taylor P. Thyroid-associated ophthalmopathy: pathogenesis and clinical management. Baillière's Clin Endocrinol Metab 1995;9:115-35.
7. Ludgate M, Crisp M, Lane C, et al. The thyrotropin receptor in thyroid eye disease. Thyroid 1998;8:411-3.
8. Heufelder AE. Involvement of the orbital fibroblast and TSH receptor in the pathogenesis of Graves' ophthalmopathy. Thyroid 1995;5:331-40.
9. Char DH. Thyroid eye disease. Br J Ophthalmol 1996;80: 922-6.
10. Kroll AJ, Kuwabara T. Dysthyroid ocular myopathy: anatomy, histology, and electron microscopy. Arch Ophthalmol 1966;76:244-57.
11. Riley FC. Orbital pathology in Graves' disease. Mayo Clin Proc 1972;47:975-9.
12. Hufnagel TJ, Hickey WF, Cobbs NH, et al. Immunohistochemical and ultrastructural studies on the exenterated orbital tissues of a patient with Graves' disease. Ophthalmology 1984;91:1411-19.
13. Tallstedt L, Norberg R. Immunohistochemical staining of normal and Graves' extraocular muscle. Invest Ophthalmol Vis Sci 1988;29:175-84.
14. Campbell RJ. Immunology of Graves' ophthalmopathy: retrobulbar histology and histochemistry. Acta Endocrinol (Copenh) 1989;121:9-16.
15. Weetman AP, Cohen S, Gatter KC, et al. Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy. Clin Exp Immunol 1989;75:222-7.
16. Bagnasco M, Venuti D, Prigione I, et al. Graves' disease: phenotypic and functional analysis at the clonal level of the T-cell repertoire in peripheral blood and in thyroid. Clin Immunol Immunopathol 1988;47:230-9.
17. Werner SC. Modification of the classification of the eye changes of Graves' disease. Am J Ophthalmol 1977;83: 725-7.
18. Enzmann DR, Donaldson S, Kriss JP. Appearance of Graves' disease on orbital computed tomography. J Computer Assist Tomogr 1979;3:815-19.
19. Werner SC, Coleman DJ, Franzen LA. Ultrasonographic evidence of a consistent orbital involvement in Graves' disease. N Engl J Med 1974;290:1447-50.
20. Hiromatsu Y, Tanaka K, Ishisaka N, et al. Human histocompatibility leukocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 1995;80:685-91.
21. Pappa A, Calder V, Fells P, et al. Adhesion molecule expression in vivo and in vitro on extraocular muscles in early and late thyroid associated ophthalmopathy. Clin Exp Immunol 1997;108:309-13.
22. Van der Gaag R, Vernimmen R, Fiebelkorn N, et al. Graves' ophthalmopathy: what is the evidence for extraocular muscle specific autoantibodies. Int Ophthalmol 1990;14: 25-30.
23. Hanafusa T, Pujol-Borrell R, Chiovato L, et al. Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 1983;ii: 1111-15.
24. Lombardi G, Arnold K, Uren J, et al. Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin 2 (IL-2) and supports IL-4 production by B7-dependent human T-cells. Eur J Immunol 1997;27:62-71.
25. Sergott RC, Glaser JS. Graves' ophhalmopathy. a clinical and immunologic review. Surv Ophthalmol 1981;26:1-21.
26. Pappa A, Calder V, Ajjan R, et al. Analysis of extraocular muscle infiltrating T-cells in thyroid associated ophthalmopathy. Clin Exp Immunol 1997;109:362-9.
27. Lin HY, Martino LJ, Wilcox BD, et al. Potentiation by thyroid hormone of human IFN-gamma-induced HLA-DR expression. J Immunol 1998;161:843-9.
28. Sempowski GD, Rozenblit J, Smith TJ, et al. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. Am J Physiol 1998;274: C707-14.
29. Solomon DH, Chopra IJ, Chopra U, et al. Identification of subgroups of euthyroid Graves' ophthalmopathy. N Engl J Med 1977;296:181-6.
30. Perros P, Kendall-Taylor P. Pathogenetic mechanisms in thyroid-associated ophthalmopathy. J Intern Med 1992; 231:205-11.