Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats

Cardiovascular Research

Volumn 46, Issue 1, 2000, Pages 66-72

  Jain, Mohit ^a   Liao, Ronglih ^a   Ngoy, Soeun ^a   Whittaker, Peter ^b   Apstein, Carl S ^a   Eberli, Franz R ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c BERN UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Fibrosis; Infarction; Remodelling; Renin angiotensin system; Ventricular function

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOSARTAN;

ACUTE HEART INFARCTION; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXERCISE; HEART INFARCTION SIZE; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRAINING;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; LOSARTAN; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; PERFUSION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; VENTRICULAR REMODELING;

EID: 0034060165     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00429-0     Document Type: Article

References (43)

1. Pfeffer M.A., Braunwald E. Remodelling after myocardial infarction: experimental observations and clinical implications. Circulation. 81:1990;1161-1172.
2. Anversa P., Li P., Zhang X., Olivetti G., Capasso J. Ischaemic myocardial injury and ventricular remodelling. Cardiovasc Res. 27:1993;145-157.
3. Fletcher G.F., Balady G., Blair S.N., et al. Statement of exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on exercise and cardiac rehabilitation of the council on clinical cardiology. American Heart Association. Circulation. 94:1996;857-862.
4. Jugdutt B.I., Michorowski B.L., Kappagoda C.T. Exercise training after anterior Q wave myocardial infarction: importance of regional left ventricular function and topography. J Am Coll Cardiol. 12:1988;362-372.
5. Giannuzzi P., Tavazzi L., Temporelli P.L., et al. EAMI Study Group. Long terms physical training and left ventricular remodelling after anterior myocardial infarction: results of the exercise in anterior myocardial infarction (EAMI) trial. J Am Coll Cardiol. 22:1993;1821-1829.
6. Dubach P., Myers J., Dziekan G., et al. Effect of exercise training on myocardial remodelling in patients with reduced left ventricular function after myocardial infarction. Circulation. 95:1997;2060-2067.
7. Giannuzzi P., Temporelli P.L., Corra U., Gattone M., Giordano A., Tavazzi L. for the ELVD Study Group. Attenuation of unfavorable remodelling by exercise training in postinfarction patients with left ventricular dysfunction. Circulation. 96:1997;1790-1797.
8. Gaudron P., Hu K., Schamberger R., Budin M., Walter B., Ertl G. Effect of endurance training early or later after coronary artery occlusion on left ventricular remodelling, hemodynamics and survival in rats with chronic transmural myocardial infarction. Circulation. 89:1994;402-412.
9. Oh B.H., Ono S., Rockman H.A., Ross J. Jr. Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion. Circulation. 87:1993;598-607.
10. Kloner R.A., Kloner J.A. The effect of early exercise on myocardial infarct scar formation. Am Heart J. 106:1983;1009-1013.
11. Hammerman H., Schoen F.J., Kloner R.A. Short-term exercise has a prolonged effect on scar formation after experimental acute myocardial infarction. J Am Coll Cardiol. 2:1983;979-982.
12. Orenstein T.L., Parker T.G., Butany J.W., et al. Favorable left ventricular remodelling following large myocardial infarction by exercise training. J Clin Invest. 96:1995;858-866.
13. Pfeffer J.M., Pfeffer M.A., Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res. 57:1985;84-95.
14. Litwin S.E., Katz S.E., Weinberg E.O., Lorell B.H., Aurigemma G.P., Douglas P.S. Serial echocardiographic-doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Circulation. 91:1995;2642-2654.
15. Pfeffer M.A., Braunwald E., Moye L.A., et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. New Engl J Med. 327:1992;669-677.
16. Effects of enalapril on mortality in severe congestive heart failure: results of the cooperative North Scandinavian enalapril survival study (Consensus). New Engl J Med. 316:1987;1429-1435.
17. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet. 342:1993;821-828.
18. Liu Y.E., Yang X.P., Sharov V.G., et al. Effects of angiotensin-coverting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. J Clin Invest. 99:1997;1926-1935.
19. Raya T.E., Fonken S.J., Lee R.W., et al. Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure. Am J Hypertens. 4:1991;334S-340S.
20. Schieffer B., Wirger A., Meybrunn M., et al. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodelling after myocardial infarction in the rat. Circulation. 89:1994;2273-2282.
21. Pitt B., Segal R., Martinez F.A., et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study (ELITE). Lancet. 349:1997;747-752.
22. Eberli F.R., Weinberg E.O., Grice W.M., Horowitz G., Apstein C.S. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ Res. 68:1991;466-481.
23. Fletcher P.J., Pfeffer J.M., Pfeffer M.A., Braunwald E. Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarctions. Effects on systolic function. Circ Res. 49:1981;618-626.
24. Whittaker P., Kloner R.A., Boughner D.R., Pickering J.G. Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol. 89:1994;397-410.
25. Flaim S.F., Minteer W.J., Clark D.P., Zelis R. Cardiovascular response to acute aquatic and treadmill exercise in the untrained rat. J Appl Physiol. 46:1979;302-308.
26. Hochman J.S., Healy B. Effect of exercise on acute myocardial infarction in rats. J Am Coll Cardiol. 7:1986;126-132.
27. Musch T.I., Moore R.L., Leathers D.J., Bruno A., Zelis R. Endurance training in rats with chronic heart failure induced by myocardial infarction. Circulation. 74:1986;431-441.
28. Niebauer J., Cooke J.P. Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol. 28:1996;1652-1660.
29. Froelicher V.F., Jensen D., Genter F., et al. A randomized trial of exercise training in patients with coronary artery disease. J Am Med Assoc. 252:1984;1291-1297.
30. Cooksey J.D., Reilly P., Brown S., Bomze H., Cryer P.L. Exercise training and plasma catecholamines in patients with ischemic heart disease. Am J Cardiol. 42:1978;372-376.
31. Hull S.S. Jr., Vanoli E., Adamson P.B., et al. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation. 89:1994;548-552.
32. Goldsmitt R.L., Bigger J.T. Jr., Steiman R.C., Fleiss J.L. Comparison of 24-h parasympathetic activity in endurance-trained and untrained young men. J Am Coll Cardiol. 20:1992;552-558.
33. Jain M., Apstein C.A., Libonati J.R., Ngoy S., Whittaker P., Eberli F.R. Effects of Losartan and exercise on post-MI remodelling and contractility. Circulation. 96:(Suppl):1997;1924. Abstract.
34. Sladek T., Sladkova J., Kolar F. The effect of AT1 receptor anatagonist on chronic cardiac response to coronary artery ligation in rats. Cardiovasc Res. 31:1996;568-576.
35. Mortorana P.A., Kettenback B., Brelpohl G., Linz W., Scholkens B.A. Reduction of infarct size by local angiotension coverting enzyme inhibition is abolished by bradykinin antagonist. Eur J Pharmacol. 182:1990;395-396.
36. Linz W., Scholkens B.A. Role of bradykinin in the cardiac effects of angiotensin converting enzyme inhibitors. J Cardiovasc Pharmacol. 20:(Suppl 9):1992;S83-S90.
37. Hartmann J.C., Wall T.M., Hullinger T.G., Shebuski R.J. Reduction of myocardial infarct size in rabbits by ramiprilat: reversal by the bradykinin antagonist HOE 140. J Cardiovasc Pharmacol. 21:1993;996-1003.
38. Stauss H.M., Zhu Y.C., Redlich T., et al. Angiotensin-converting enzyme inhibition in infarct-induced heart failure in rats: bradykinin versus angiotensin II. J Cardiovasc Risk. 1:1994;255-262.
39. Campbell D.J., Kladis A., Valentijn A.J. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol. 26:1995;233-240.
40. Nio Y., Matsubara H., Murasawa S., Kanasaki M., Inada M. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest. 95:1995;46-54.
41. Jugdutt B.I., Lucas A., Khan M.I. Effect of angiotensin-converting enzyme inhibition on infarct collagen deposition and remodelling during healing after transmural canine myocardial infarction. Can. J Cardiol. 13:1997;657-668.
42. Yamagishi H., Kim S., Niskikimi T., Takeuchi K., Takeda T. Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardial-infarcted rats. J Moll Cell Cardiol. 25:1993;1369-1380.
43. Smits J.F., van Krimpen C., Schoemaker R.G., Cleutjens J.P., Daemen M.J. Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content. J Cardiovasc Pharmacol. 20:1992;772-778.