Enhancing initial release of peptide from poly(d,l-lactide-co-glycolide) (PLGA) microspheres by addition of a porosigen and increasing drug load

Pharmaceutical Development and Technology

Volumn 5, Issue 2, 2000, Pages 287-296

  Ravivarapu, Harish B ^a   Lee, Heeyong ^b   DeLuca, Patrick P ^c  

^a QLT Inc   (United States)

^b Hyundai Pharm Ind Co Ltd   (South Korea)

^c University of Kentucky   (United States)

Author keywords

Drug load; In vitro characteristics; In vivo efficacy; Leuprolide acetate; Peptide; PLGA microspheres; Porosigen

Indexed keywords

GONADORELIN DERIVATIVE; LEUPRORELIN; MICROSPHERE; POLYGLACTIN; RESOMER; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; MALE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TESTOSTERONE SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CALCIUM CHLORIDE; DRUG CARRIERS; LACTIC ACID; LEUPROLIDE; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PEPTIDES; POLYGLYCOLIC ACID; POLYMERS; POROSITY; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES;

EID: 0034059624     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100100543     Document Type: Article

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