메뉴 건너뛰기




Volumn 97, Issue 1, 2000, Pages 98-106

Pharmacogenetics of schizophrenia

Author keywords

Cytochrome P450 enzymes; Dopamine receptors; Pharmacogenomics; Serotonin receptors; SNP

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CHLORPROMAZINE; CLOZAPINE; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DIHYDROERGOTAMINE; DOPAMINE; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; DRUG METABOLIZING ENZYME; KETANSERIN; METHYSERGIDE; NEUROLEPTIC AGENT; RISPERIDONE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR; SUMATRIPTAN; NEUROTRANSMITTER RECEPTOR; PSYCHOTROPIC AGENT;

EID: 0034059097     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(200021)97:1<98::AID-AJMG12>3.0.CO;2-W     Document Type: Review
Times cited : (47)

References (101)
  • 1
    • 0032962216 scopus 로고    scopus 로고
    • CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine, fluvoxamine, paroxetine, or sertraline
    • Alfaro CL, Lam YW, Simpson J, Ereshefsky L. 1999. CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine, fluvoxamine, paroxetine, or sertraline. J Clin Psychopharmacol 19:155-163.
    • (1999) J Clin Psychopharmacol , vol.19 , pp. 155-163
    • Alfaro, C.L.1    Lam, Y.W.2    Simpson, J.3    Ereshefsky, L.4
  • 2
    • 0030910635 scopus 로고    scopus 로고
    • Nonfunctional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients
    • Andreassen OA, MacEwan T, Gulbrandsen AK, McCreadie RG, Stehen VM. 1997. Nonfunctional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients. Psychopharmacology 131:174-179.
    • (1997) Psychopharmacology , vol.131 , pp. 174-179
    • Andreassen, O.A.1    MacEwan, T.2    Gulbrandsen, A.K.3    McCreadie, R.G.4    Stehen, V.M.5
  • 3
    • 0030933979 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia
    • Arinami T, Gao M, Hamaguchi H, Toru M. 1997. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577-582.
    • (1997) Hum Mol Genet , vol.6 , pp. 577-582
    • Arinami, T.1    Gao, M.2    Hamaguchi, H.3    Toru, M.4
  • 4
    • 0030809767 scopus 로고    scopus 로고
    • Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype
    • Armstrong M, Daly AK, Blennerhassett R, Ferner N, Idle JR. 1997. Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype. Br J Psychiatry 170:23-26.
    • (1997) Br J Psychiatry , vol.170 , pp. 23-26
    • Armstrong, M.1    Daly, A.K.2    Blennerhassett, R.3    Ferner, N.4    Idle, J.R.5
  • 9
    • 0029049844 scopus 로고
    • Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia
    • Arthur H, Dahl ML, Siwers B, Sjöqvist F. 1995. Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia. J Clin Psychopharmacol 15:211-216.
    • (1995) J Clin Psychopharmacol , vol.15 , pp. 211-216
    • Arthur, H.1    Dahl, M.L.2    Siwers, B.3    Sjöqvist, F.4
  • 11
    • 0029120447 scopus 로고
    • Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
    • Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HHM. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65:1157-1165.
    • (1995) J Neurochem , vol.65 , pp. 1157-1165
    • Asghari, V.1    Sanyal, S.2    Buchwaldt, S.3    Paterson, A.4    Jovanovic, V.5    Van Tol, H.H.M.6
  • 20
    • 0032964679 scopus 로고    scopus 로고
    • Polymorphic cytochromes P450 and drugs used in psychiatry
    • Coutts RT, Urichuk LJ. 1999. Polymorphic cytochromes P450 and drugs used in psychiatry. Cell Mol Neurobiol 19:325-354.
    • (1999) Cell Mol Neurobiol , vol.19 , pp. 325-354
    • Coutts, R.T.1    Urichuk, L.J.2
  • 21
    • 0029860139 scopus 로고    scopus 로고
    • Functional analysis of the human D2 dopamine receptor missense variants
    • Cravchik A, Sibley DR, Gejman PV. 1996. Functional analysis of the human D2 dopamine receptor missense variants. J Biol Chem 271:26013-26017.
    • (1996) J Biol Chem , vol.271 , pp. 26013-26017
    • Cravchik, A.1    Sibley, D.R.2    Gejman, P.V.3
  • 22
    • 0032891646 scopus 로고    scopus 로고
    • Analysis of neuroleptic binding affinities and potencies for the different human D2 dopamine receptor missense variants
    • Cravchik A, Sibley DR, Gejman PV. 1999. Analysis of neuroleptic binding affinities and potencies for the different human D2 dopamine receptor missense variants. Pharmacogenetics 9:17-23.
    • (1999) Pharmacogenetics , vol.9 , pp. 17-23
    • Cravchik, A.1    Sibley, D.R.2    Gejman, P.V.3
  • 23
    • 0032803472 scopus 로고    scopus 로고
    • Functional analysis of the human D5 dopamine receptor missense and nonsense variants: Differences in dopamine binding affinities
    • Cravchik A, Gejman PV. 1999. Functional analysis of the human D5 dopamine receptor missense and nonsense variants: differences in dopamine binding affinities. Pharmacogenetics 9:199-206.
    • (1999) Pharmacogenetics , vol.9 , pp. 199-206
    • Cravchik, A.1    Gejman, P.V.2
  • 24
    • 0027483214 scopus 로고
    • Genetically variable metabolism of antidepressants and neuroleptic drugs in man
    • Dahl M-L, Bertilsson L. 1993. Genetically variable metabolism of antidepressants and neuroleptic drugs in man. Pharmacogenetics 3: 61-70.
    • (1993) Pharmacogenetics , vol.3 , pp. 61-70
    • Dahl, M.-L.1    Bertilsson, L.2
  • 28
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating fnnctional genomics into rational therapeutics
    • Evans WE, Relling MV. 1999. Pharmacogenomics: translating fnnctional genomics into rational therapeutics. Science 286:487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 29
    • 0032980471 scopus 로고    scopus 로고
    • Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs
    • Fang J, Gorrod JW. 1999. Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs. Cell Mol Neurobiol 19:491-510.
    • (1999) Cell Mol Neurobiol , vol.19 , pp. 491-510
    • Fang, J.1    Gorrod, J.W.2
  • 30
    • 0032574470 scopus 로고    scopus 로고
    • Scanning of the dopamine D and D5 receptor genes by REF in neuropsychiatric patients reveals a novel missense change at a highly conserved amino acid
    • Feng J, Sobell JL, Heston LL, Cook EH Jr, Goldman D, Sommer SS. 1998. Scanning of the dopamine D and D5 receptor genes by REF in neuropsychiatric patients reveals a novel missense change at a highly conserved amino acid. Am J Med Genet 81:172-178.
    • (1998) Am J Med Genet , vol.81 , pp. 172-178
    • Feng, J.1    Sobell, J.L.2    Heston, L.L.3    Cook E.H., Jr.4    Goldman, D.5    Sommer, S.S.6
  • 33
    • 0028157902 scopus 로고
    • No structural mutation in the dopaminc D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis
    • Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble EP, Kranzler HR, O'Malley S. 1994. No structural mutation in the dopaminc D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 271:204-208.
    • (1994) JAMA , vol.271 , pp. 204-208
    • Gejman, P.V.1    Ram, A.2    Gelernter, J.3    Friedman, E.4    Cao, Q.5    Pickar, D.6    Blum, K.7    Noble, E.P.8    Kranzler, H.R.9    O'Malley, S.10
  • 37
  • 40
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects wth diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M. 1994. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects wth diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 46:452-459.
    • (1994) Mol Pharmacol , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3    Bertilsson, L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 42
    • 0031461131 scopus 로고    scopus 로고
    • Pharmacogeneties in biological perspective
    • Kalow W. 1997. Pharmacogeneties in biological perspective. Pharmacol Rev 49:369-379.
    • (1997) Pharmacol Rev , vol.49 , pp. 369-379
    • Kalow, W.1
  • 44
    • 0029998089 scopus 로고    scopus 로고
    • Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma
    • Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawi Y. 1996. Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Am J Hum Genet 59:1084-1090.
    • (1996) Am J Hum Genet , vol.59 , pp. 1084-1090
    • Kato, M.V.1    Shimizu, T.2    Nagayoshi, M.3    Kaneko, A.4    Sasaki, M.S.5    Ikawi, Y.6
  • 45
    • 0032544336 scopus 로고    scopus 로고
    • Genetic variation as a guide to drug development
    • Kleyn PW, Vesell ES. 1998. Genetic variation as a guide to drug development. Science 281: 1820-1821.
    • (1998) Science , vol.281 , pp. 1820-1821
    • Kleyn, P.W.1    Vesell, E.S.2
  • 49
    • 0031955702 scopus 로고    scopus 로고
    • Predicting effective drug concentrations for individual patients
    • Levy G. 1998. Predicting effective drug concentrations for individual patients. Clin Pharmacokinet 34:323-333.
    • (1998) Clin Pharmacokinet , vol.34 , pp. 323-333
    • Levy, G.1
  • 51
    • 0002964661 scopus 로고    scopus 로고
    • No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia clozapine response in a Chinese population
    • Lin C-H, Tsai S-J, Yu YW-Y, Song H-L, Tu P-C, Sim C-B, Hsu C-P, Yang K-H, Hong C-J. 1999. No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia clozapine response in a Chinese population. NeuroReport 10:57-60.
    • (1999) NeuroReport , vol.10 , pp. 57-60
    • Lin, C.-H.1    Tsai, S.-J.2    Yu, Y.-Y.3    Song, H.-L.4    Tu, P.-C.5    Sim, C.-B.6    Hsu, C.-P.7    Yang, K.-H.8    Hong, C.-J.9
  • 53
    • 0030017515 scopus 로고    scopus 로고
    • Interethnic differences in drug metabolism: Influence of genetic and environmental factors on debrisoquine hydroxylation phenotype
    • Llerena A, Cobaleda J, Martinez C, Benitez J, 1996. Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype. Eur J Drug Metab Pharmacokinet 21:12-138.
    • (1996) Eur J Drug Metab Pharmacokinet , vol.21 , pp. 12-138
    • Llerena, A.1    Cobaleda, J.2    Martinez, C.3    Benitez, J.4
  • 54
    • 0030598907 scopus 로고    scopus 로고
    • Proposed schizophrenia-related gene polymorphism: Expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system
    • Lundstrom K, Turpin M. 1996. Proposed schizophrenia-related gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system. Biochem Biophys Res Commun 225:1068-1072.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 1068-1072
    • Lundstrom, K.1    Turpin, M.2
  • 58
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • Marez D, Legrand M, Sabbagb N, Lo Guidice J-M, Spire C, Lafitte J-J, Meyer UA, Broly F. 1997. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 7:193-202.
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagb, N.3    Lo Guidice, J.-M.4    Spire, C.5    Lafitte, J.-J.6    Meyer, U.A.7    Broly, F.8
  • 61
    • 0033560279 scopus 로고    scopus 로고
    • As consortium plans free SNP map of human genome
    • Masood E. 1999. As consortium plans free SNP map of human genome. Nature 398:545-546.
    • (1999) Nature , vol.398 , pp. 545-546
    • Masood, E.1
  • 62
    • 0032588999 scopus 로고    scopus 로고
    • Effects of the CYP2D610 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
    • Mihara K, Suzuki A, Kondo T, Yasin N, Furukori H, Nagashima U, Otani K, Kaneko S, Inone Y. 1999. Effects of the CYP2D610 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia. Clin Pharmacol Ther 65:291-294.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 291-294
    • Mihara, K.1    Suzuki, A.2    Kondo, T.3    Yasin, N.4    Furukori, H.5    Nagashima, U.6    Otani, K.7    Kaneko, S.8    Inone, Y.9
  • 63
    • 70449136457 scopus 로고
    • Drug reactions, enzymes, and biochemical genetics
    • Motulsky AG. 1957. Drug reactions, enzymes, and biochemical genetics. J Am Med Assoc 165:835-837.
    • (1957) J Am Med Assoc , vol.165 , pp. 835-837
    • Motulsky, A.G.1
  • 64
    • 0028988859 scopus 로고
    • Two naturally occurring amino acid substitutions in the human 5-HTIA receptor: Glycine 22 to serine 22 and isoleucine 28 to valine 28
    • Nakhai B, Nielsen DA, Linnoila M, Goldman D. 1995. Two naturally occurring amino acid substitutions in the human 5-HTIA receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochem Biophys Res Commun 210:530-536.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 530-536
    • Nakhai, B.1    Nielsen, D.A.2    Linnoila, M.3    Goldman, D.4
  • 70
    • 0032572599 scopus 로고    scopus 로고
    • Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics
    • Ohmori O, Suzuki T, Kojima H, Shinkai T, Terao T, Mita T, Abe K. 1998. Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics. Schizophr Res 32:107-113.
    • (1998) Schizophr Res , vol.32 , pp. 107-113
    • Ohmori, O.1    Suzuki, T.2    Kojima, H.3    Shinkai, T.4    Terao, T.5    Mita, T.6    Abe, K.7
  • 72
    • 0032860134 scopus 로고    scopus 로고
    • In vitro study on the involvement of CYPlA2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol
    • Pan L, Belpaire FM. 1999. In vitro study on the involvement of CYPlA2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol. Eur J Clin Pharmacol 55:599-604.
    • (1999) Eur J Clin Pharmacol , vol.55 , pp. 599-604
    • Pan, L.1    Belpaire, F.M.2
  • 73
    • 0031886030 scopus 로고    scopus 로고
    • The business of pharmacogenomics
    • Persidis A. 1998. The business of pharmacogenomics. Nature Biotechnol 16:209-210.
    • (1998) Nature Biotechnol , vol.16 , pp. 209-210
    • Persidis, A.1
  • 78
    • 0015733114 scopus 로고
    • Pharmacogenetic aspects of psychoactive drugs: Facts and fancy
    • Propping P, Kopun M. 1973. Pharmacogenetic aspects of psychoactive drugs: facts and fancy. Humangenetik 20:291-320.
    • (1973) Humangenetik , vol.20 , pp. 291-320
    • Propping, P.1    Kopun, M.2
  • 79
    • 0028856556 scopus 로고
    • Genetic variation of CNS receptors - A new perspective for pharmacogenetics
    • Propping P, Nöthen MM. 1995. Genetic variation of CNS receptors - a new perspective for pharmacogenetics. Pharmacogenetics 5: 318-325.
    • (1995) Pharmacogenetics , vol.5 , pp. 318-325
    • Propping, P.1    Nöthen, M.M.2
  • 83
    • 0033602828 scopus 로고    scopus 로고
    • Application of pharmacogenetics to psychotic disorders: The first consensus conference
    • Rietschel M, Kennedy JL, Macciardi F, Meltzer HY and the Consensus Group for Outcome Measures in Psychoses for Pharmacological Studies. 1999. Application of pharmacogenetics to psychotic disorders: the first consensus conference. Schizophr Res 37:191-196.
    • (1999) Schizophr Res , vol.37 , pp. 191-196
    • Rietschel, M.1    Kennedy, J.L.2    Macciardi, F.3    Meltzer, H.Y.4
  • 90
    • 0027319640 scopus 로고
    • Are poor inctabolizers of sparteine/debrisoquine less pain tolerant than extensive metabolizers?
    • Sindrup SH, Poulsen L, Brosen K, Arendt-Nielsen L, Gram LF. 1993. Are poor inctabolizers of sparteine/debrisoquine less pain tolerant than extensive metabolizers? Pain 53:335-339.
    • (1993) Pain , vol.53 , pp. 335-339
    • Sindrup, S.H.1    Poulsen, L.2    Brosen, K.3    Arendt-Nielsen, L.4    Gram, L.F.5
  • 91
    • 0028960869 scopus 로고
    • The D5 dopamine receptor gene in schizophrenia: Identification of a nonsense change and multiple missense changes but lack of association with disease
    • Sobell JL, Lind TJ, Sigurdson C, Zald DH, Snitz BE, Grove WM, Heston LL, Sommer SS. 1995. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet 4:507-514.
    • (1995) Hum Mol Genet , vol.4 , pp. 507-514
    • Sobell, J.L.1    Lind, T.J.2    Sigurdson, C.3    Zald, D.H.4    Snitz, B.E.5    Grove, W.M.6    Heston, L.L.7    Sommer, S.S.8
  • 93
  • 96
    • 0030903368 scopus 로고    scopus 로고
    • Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients
    • Steen VM, Lovlie R, MacEwan T, McCreadie RG. 1997. Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients. Mol Psychiatry 2:139-145.
    • (1997) Mol Psychiatry , vol.2 , pp. 139-145
    • Steen, V.M.1    Lovlie, R.2    MacEwan, T.3    McCreadie, R.G.4
  • 98
    • 0002150481 scopus 로고
    • Moderne probleme der humangenetik
    • Vogel F. 1959. Moderne Probleme der Humangenetik. Ergebn Inn Med Kinderheilk 12: 52-125.
    • (1959) Ergebn Inn Med Kinderheilk , vol.12 , pp. 52-125
    • Vogel, F.1
  • 100
    • 0033151546 scopus 로고    scopus 로고
    • Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: Difference in chiral preference of CYP2C9 and CYP2C19
    • Yasumori T, Chen LS, Li QH, Ueda M, Tsuzuki T, Goldstein JA, Kato R, Ymazoe Y. 1999. Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. Biochem Pharmacol 57:1297-1303.
    • (1999) Biochem Pharmacol , vol.57 , pp. 1297-1303
    • Yasumori, T.1    Chen, L.S.2    Li, Q.H.3    Ueda, M.4    Tsuzuki, T.5    Goldstein, J.A.6    Kato, R.7    Ymazoe, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.