Cyclophosphamides as hypoxia-activated diffusible cytotoxins: A theoretical study

Journal of Computer-Aided Molecular Design

Volumn 14, Issue 4, 2000, Pages 307-316

  Wu, Jian Hui ^a   Reynolds, Christopher A ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Bioreductive; Cyclophosphamides; Molecular orbital; Nitroimidazole; Tirapazamine

Indexed keywords

CHEMICAL ACTIVATION; CLINICAL RESEARCH; DENSITY FUNCTIONAL THEORY; DRUG INTERACTIONS;

ANTICANCER DRUG; BIOREDUCTIVE; CLINICAL USE; CYCLOPHOSPHAMIDE; CYTOTOXINS; NITROIMIDAZOLES; SIDE EFFECT; THEORETICAL INVESTIGATIONS; THEORETICAL STUDY; TIRAPAZAMINE;

MOLECULAR ORBITALS;

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ANION; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE DERIVATIVE; CYTOTOXIN; DRUG METABOLITE; NITROIMIDAZOLE DERIVATIVE; RADICAL; TIRAPAZAMINE;

ARTICLE; CALCULATION; CELL HYPOXIA; CHEMICAL ANALYSIS; CONTROLLED STUDY; DENSITY; DRUG STRUCTURE; ELECTRON; PRIORITY JOURNAL; REDUCTION; SOLVATION; THEORETICAL STUDY;

EID: 0034058283     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008128023564     Document Type: Article

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