Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95

Biology of the Cell

Volumn 92, Issue 1, 2000, Pages 27-37

  Ørstavik, Sigurd ^a   Eide, Turid ^a   Collas, Philippe ^a   Han, Inn oc ^b   Taskén, Kjetil ^a   Kieff, Elliot ^b   Jahnsen, Tore ^a   Skålhegg, Bjørn Steen ^a,c  

^a UNIVERSITY OF OSLO   (Norway)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

Author keywords

Cyclic AMP; Nuclear protein HA95; Protein kinase

Indexed keywords

AMINO ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; NUCLEAR PROTEIN; PROTEIN HA95; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CHROMOSOME 19P; CLONING; CONTROLLED STUDY; GENE LOCUS; HUMAN; HUMAN TISSUE; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY;

EID: 0034057628     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-4900(00)88761-4     Document Type: Article

References (16)

1. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs, Nucleic Acids Res. 25 (1997) 3389-3402.
2. Coghlan V.M., Langeberg L.K., Fernandez A., Lamb N.J., Scott J.D., Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase, J. Biol Chem. 269 (1994) 7658-7665.
3. Collas P., Le Guellec K., Tasken K., The A-kinase-anchoring protein AKAp95 is a multivalent protein with a key role in chromatin condensation at mitosis, J. Cell Biol. 147 (1999a) 1167-1186.
4. Collas P., Liang M.R., Vincent M., Alestrom P., Active transgenes in zebrafish are enriched in acetylated histone H4 and dynamically associate with RNA pol II and splicing complexes, J. Cell Sci. 112 (1999b) 1045-1054.
5. Dingwall C., Laskey R.A., Nuclear targeting sequences - A consensus?, Trends Biochem. Sci. 16 (1991) 478-481.
6. Eide T., Coghlan V.M., Ørstavik S., Holsve C., Solberg R., Skalhegg B.S., Lamb N.J., Langeberg L.K., Fernandez A., Scott J.D., Jahnsen T., Tasken K., Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95, Exp. Cell Res. 238 (1998) 305-316.
7. Evan G.I., Lewis G.K., Ramsay G., Bishop J.M., Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product, Mol. Cell. Biol. 5 (1985) 3610-3616.
8. He D.C., Niockerson I.A., Penman S., Core filaments of nuclear matrix, J. Cell Biol. 110 (1990) 569-580.
9. Kozak M., Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eucaryotic ribosomes, Cell 44 (1986) 283-292.
10. Lester L.B., Scott J.D., Anchoring and scaffold proteins for kinases and phosphatases Rec. Progr. Hormone Res. 52 (1997) 409-430.
11. Rubin C.S., A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim. Biophys. Acta 1224 (1994) 467-479.
12. Scott J.D., Dissection of protein kinase and phosphatase targeting interaction, Soc. Gen. Physiol. Ser. 52 (1997) 227-239.
13. Skålhegg B.S., Landmark B.F., Foss K.B., Lohmann S.M., Hansson V., Lea T., Jahnsen T., Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine RIIs, J. Biol. Chem. 267 (1992) 5374-5379.
14. Skålhegg B.S., Witczak O., Reinton N., Bide T., Eikvar S., Collas P., Taskén K., Jahnsen T., Ørstavik S., Specific effects of cAMP are mediated by multiple isozymes of cAMP-dependent protein kinase bound to A-kinase anchoring proteins, J. Mol. Biol. Biotech, 1 (1999) 49-63.
15. Witczak O., Skålhegg B.S., Keryer G., Bornens M., Taskén K., Jahnsen T., Ørstavik S., Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450, EMBO J. 18 (1999) 1868-1869.
16. Zhang Q., Carr D.W., Lerea K.M., Scott J.D., Newman S.A., Nuclear localization of type II cAMP-dependent protein kinase during limb cartilage differentiation is associated with a novel developmentally regulated A-kinase anchoring protein, Dev. Biol. 176 (1996) 51-61.