-
1
-
-
0024328536
-
Altering the genome by homologous recombination
-
Capecchi, M. R. 1989. Altering the genome by homologous recombination. Science 244:1288-1292.
-
(1989)
Science
, vol.244
, pp. 1288-1292
-
-
Capecchi, M.R.1
-
2
-
-
0026689409
-
Altering genes in animals by gene targeting
-
Koller, B. H., and O. Smithies. 1992. Altering genes in animals by gene targeting. Annu. Rev. Immunol. 10:705-730.
-
(1992)
Annu. Rev. Immunol.
, vol.10
, pp. 705-730
-
-
Koller, B.H.1
Smithies, O.2
-
3
-
-
0001488205
-
Characterization of the human 5-lipoxygenase gene
-
Funk, C. D., T. Matsumoto, S. Hoshiko, O. Rådmark, and B. Samuelsson. 1989. Characterization of the human 5-lipoxygenase gene. Proc. Natl. Acad. Sci. U.S.A. 86:2587-2591.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 2587-2591
-
-
Funk, C.D.1
Matsumoto, T.2
Hoshiko, S.3
Rådmark, O.4
Samuelsson, B.5
-
4
-
-
0026504293
-
Characterization of human 12-lipoxygenase genes
-
Funk, C. D., L. B. Funk, G. A. FitzGerald, and B. Samuelsson. 1992. Characterization of human 12-lipoxygenase genes. Proc. Natl. Acad. Sci. U.S.A. 89:3962-3966.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 3962-3966
-
-
Funk, C.D.1
Funk, L.B.2
Fitzgerald, G.A.3
Samuelsson, B.4
-
5
-
-
0023713199
-
Molecular cloning and amino acid sequence of human 5-lipoxygenase
-
Matsumoto, T., C. D. Funk, O. Rådmark, J. O. Höög, H. Jörnvall, and B. Samuelsson. 1988. Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc. Natl. Acad. Sci. U.S.A. 85:26-30.
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 26-30
-
-
Matsumoto, T.1
Funk, C.D.2
Rådmark, O.3
Höög, J.O.4
Jörnvall, H.5
Samuelsson, B.6
-
7
-
-
0028340214
-
Targeted gene disruption by homologous recombination: Toward an understanding of specific blood cell functions
-
Funk, C. D., U. Kurre, and G. Griffis. 1994. Targeted gene disruption by homologous recombination: toward an understanding of specific blood cell functions. Ann. N.Y. Acad. Sci. 714:253-258.
-
(1994)
Ann. N.Y. Acad. Sci.
, vol.714
, pp. 253-258
-
-
Funk, C.D.1
Kurre, U.2
Griffis, G.3
-
8
-
-
0027945466
-
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
-
Chen, X. S., J. R. Sheller, E. N. Johnson, and C. D. Funk. 1994. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature (London) 372:179-182.
-
(1994)
Nature (London)
, vol.372
, pp. 179-182
-
-
Chen, X.S.1
Sheller, J.R.2
Johnson, E.N.3
Funk, C.D.4
-
9
-
-
0029182291
-
Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene
-
Funk, C D., X. S. Chen, U. Kurre, and G. Griffis. 1995. Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene. Adv. Prostaglandin Thromboxane Leukotriene Res. 23:145-150.
-
(1995)
Adv. Prostaglandin Thromboxane Leukotriene Res.
, vol.23
, pp. 145-150
-
-
Funk, C.D.1
Chen, X.S.2
Kurre, U.3
Griffis, G.4
-
10
-
-
0030580406
-
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice
-
Funk, C. D. 1996. The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. Biochim. Biophys. Acta 1304:65-84.
-
(1996)
Biochim. Biophys. Acta
, vol.1304
, pp. 65-84
-
-
Funk, C.D.1
-
11
-
-
0005142016
-
The role of 5-lipoxygenase products in a mouse model of allergic airway inflammation
-
A. Szczeklik, R. J. Gryglewski, and J. R. Vane, editors. Marcel Dekker, New York
-
Funk, C. D., X.-S. Chen, Y.-P. Tu, J. R. Sheller, and C. G. Irvin. 1998. The role of 5-lipoxygenase products in a mouse model of allergic airway inflammation. In A. Szczeklik, R. J. Gryglewski, and J. R. Vane, editors. Eicosanoids, Aspirin and Asthma. Marcel Dekker, New York. 187-200.
-
(1998)
Eicosanoids, Aspirin and Asthma
, pp. 187-200
-
-
Funk, C.D.1
Chen, X.-S.2
Tu, Y.-P.3
Sheller, J.R.4
Irvin, C.G.5
-
12
-
-
0002397583
-
Lipid mediator deficient mice in mouse models of inflammation
-
C. N. Serhan and P. A. Ward, editors. Humana Press, Totowa, NJ
-
Funk, C. D. 1999. Lipid mediator deficient mice in mouse models of inflammation. In C. N. Serhan and P. A. Ward, editors. Molecular and Cellular Basis of Inflammation. Humana Press, Totowa, NJ.
-
(1999)
Molecular and Cellular Basis of Inflammation
-
-
Funk, C.D.1
-
13
-
-
0033278209
-
Lipoxygenase gene disruption studies: Status and applications
-
Johnson, E. N., D. Sun, X.-S. Chen, and C. D. Funk. 1999. Lipoxygenase gene disruption studies: status and applications. Adv. Exp. Med. Biol. 447:63-73.
-
(1999)
Adv. Exp. Med. Biol.
, vol.447
, pp. 63-73
-
-
Johnson, E.N.1
Sun, D.2
Chen, X.-S.3
Funk, C.D.4
-
14
-
-
0030835266
-
5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice
-
Irvin, C. G., Y. P. Tu, J. R. Sheller, and C. D. Funk. 1997. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice. Am. J. Physiol. 272:L1053-L1058.
-
(1997)
Am. J. Physiol.
, vol.272
-
-
Irvin, C.G.1
Tu, Y.P.2
Sheller, J.R.3
Funk, C.D.4
-
15
-
-
0032456011
-
Mice deficient for 5-lipoxygenase, but not 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni
-
Secor, W. E., M. R. Powell, J. Morgan, T. A. Wynn, and C. D. Funk. 1999. Mice deficient for 5-lipoxygenase, but not 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni. Prostaglandins Other Lipid Mediators 56:291-304.
-
(1999)
Prostaglandins Other Lipid Mediators
, vol.56
, pp. 291-304
-
-
Secor, W.E.1
Powell, M.R.2
Morgan, J.3
Wynn, T.A.4
Funk, C.D.5
-
16
-
-
0030589226
-
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumoniae in association with decreased alveolar macrophage phagocytic and bactericidal activities
-
Bailie, M. B., T. J. Standiford, L. L. Laichalk, M. J. Coffey, R. Stricter, and M. Peters-Golden. 1996. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumoniae in association with decreased alveolar macrophage phagocytic and bactericidal activities. J. Immunol. 157:5221-5224.
-
(1996)
J. Immunol.
, vol.157
, pp. 5221-5224
-
-
Bailie, M.B.1
Standiford, T.J.2
Laichalk, L.L.3
Coffey, M.J.4
Stricter, R.5
Peters-Golden, M.6
-
17
-
-
0030898073
-
Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses
-
Byrum, R. S., J. L. Goulet, R. J. Griffiths, and B. H. Koller. 1997. Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. J. Exp. Med. 185:1065-1075.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 1065-1075
-
-
Byrum, R.S.1
Goulet, J.L.2
Griffiths, R.J.3
Koller, B.H.4
-
18
-
-
0024574581
-
The formation of lipoxins and 6,7-dihydrolipoxins by 5-lipoxygenase and reductase partially purified from potato tubers
-
Ho, H. Y., and P. Y. Wong. 1989. The formation of lipoxins and 6,7-dihydrolipoxins by 5-lipoxygenase and reductase partially purified from potato tubers. Adv. Prostaglandin Thromboxane Leukotriene Res. 19: 137-140.
-
(1989)
Adv. Prostaglandin Thromboxane Leukotriene Res.
, vol.19
, pp. 137-140
-
-
Ho, H.Y.1
Wong, P.Y.2
-
19
-
-
0029047317
-
A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis
-
Bell, E., R. A. Creelman, and J. E. Mullet. 1995. A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 92:8675-8679.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8675-8679
-
-
Bell, E.1
Creelman, R.A.2
Mullet, J.E.3
-
20
-
-
0345008359
-
On the nature of the 5-lipoxygenase reaction in human leukocytes: Enzyme purification and requirement for multiple stimulatory factors
-
Rouzer, C. A., and B. Samuelsson. 1985. On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc. Natl. Acad. Sci. U.S.A. 82: 6040-6044.
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 6040-6044
-
-
Rouzer, C.A.1
Samuelsson, B.2
-
21
-
-
0022977857
-
Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids
-
Ueda, N., S. Kaneko, T. Yoshimoto, and S. Yamamoto. 1986. Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids. J. Biol. Chem. 261:7982-7988.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 7982-7988
-
-
Ueda, N.1
Kaneko, S.2
Yoshimoto, T.3
Yamamoto, S.4
-
22
-
-
0027519767
-
Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation
-
Peters-Golden, M., and R. W. McNish. 1993. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem. Biophys. Res. Commun. 196:147-153.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.196
, pp. 147-153
-
-
Peters-Golden, M.1
McNish, R.W.2
-
23
-
-
0027964479
-
Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
-
Brock, T. G., R. Paine, and M. Peters-Golden. 1994. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J. Biol. Chem. 269:22059-22066.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 22059-22066
-
-
Brock, T.G.1
Paine, R.2
Peters-Golden, M.3
-
24
-
-
0028937635
-
5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation
-
Woods, J. W., M. J. Coffey, T. G. Brock, I. I. Singer, and M. Peters-Golden. 1995. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Invest. 95:2035-2046.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2035-2046
-
-
Woods, J.W.1
Coffey, M.J.2
Brock, T.G.3
Singer, I.I.4
Peters-Golden, M.5
-
25
-
-
0029023958
-
cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase
-
Chen, X. S., T. A. Naumann, U. Kurre, N. A. Jenkins, N. G. Copeland, and C. D. Funk. 1995. cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. J. Biol. Chem. 270:17993-17999.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17993-17999
-
-
Chen, X.S.1
Naumann, T.A.2
Kurre, U.3
Jenkins, N.A.4
Copeland, N.G.5
Funk, C.D.6
-
26
-
-
0029661982
-
The PPARalpha-leukotriene B4 pathway to inflammation control
-
Devchand, P. R., H. Keller, J. M. Peters, M. Vazquez, F. J. Gonzalez, and W. Wahli. 1996. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature (London) 384:39-43.
-
(1996)
Nature (London)
, vol.384
, pp. 39-43
-
-
Devchand, P.R.1
Keller, H.2
Peters, J.M.3
Vazquez, M.4
Gonzalez, F.J.5
Wahli, W.6
-
27
-
-
0032553552
-
Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins
-
Chen, X.-S., Y. Y. Zhang, and C. D. Funk. 1998. Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins. J. Biol. Chem. 273:31237-31244.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31237-31244
-
-
Chen, X.-S.1
Zhang, Y.Y.2
Funk, C.D.3
-
28
-
-
0030793194
-
Nucleocytoplasmic transport of macromolecules
-
Corbett, A. H., and P. A. Silver. 1997. Nucleocytoplasmic transport of macromolecules. Microbiol. Mol. Biol. Rev. 61:193-211.
-
(1997)
Microbiol. Mol. Biol. Rev.
, vol.61
, pp. 193-211
-
-
Corbett, A.H.1
Silver, P.A.2
-
29
-
-
0027449989
-
Iron content of human 5-lipoxygenase, effects of mutations regarding conserved histidine residues
-
Zhang, Y. Y., B. Lind, O. Rådmark, and B. Samuelsson. 1993. Iron content of human 5-lipoxygenase, effects of mutations regarding conserved histidine residues. J. Biol. Chem. 268:2535-2541.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 2535-2541
-
-
Zhang, Y.Y.1
Lind, B.2
Rådmark, O.3
Samuelsson, B.4
-
30
-
-
0029015335
-
Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase
-
Hammarberg, T., Y. Y. Zhang, B. Lind, O. Rådmark, and B. Samuelsson. 1995. Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase. Eur. J. Biochem. 230:401-407.
-
(1995)
Eur. J. Biochem.
, vol.230
, pp. 401-407
-
-
Hammarberg, T.1
Zhang, Y.Y.2
Lind, B.3
Rådmark, O.4
Samuelsson, B.5
-
31
-
-
0025883217
-
Human 5-lipoxygenase contains an essential iron
-
Percival, M. D. 1991. Human 5-lipoxygenase contains an essential iron. J. Biol. Chem. 266:10058-10061.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 10058-10061
-
-
Percival, M.D.1
-
32
-
-
0027246677
-
The three-dimensional structure of an arachidonic acid 15-lipoxygenase
-
Boyington, J. C., B. J. Gaffney, and L. M. Amzel. 1993. The three-dimensional structure of an arachidonic acid 15-lipoxygenase. Science 260:1482-1486.
-
(1993)
Science
, vol.260
, pp. 1482-1486
-
-
Boyington, J.C.1
Gaffney, B.J.2
Amzel, L.M.3
-
33
-
-
0030736867
-
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
-
Gillmor, S. A., A. Villasenor, R. Fletterick, E. Sigal, and M. F. Browner. 1997. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nature Struct. Biol. 4:1003-1009.
-
(1997)
Nature Struct. Biol.
, vol.4
, pp. 1003-1009
-
-
Gillmor, S.A.1
Villasenor, A.2
Fletterick, R.3
Sigal, E.4
Browner, M.F.5
-
34
-
-
0032147176
-
5-Lipoxygenase compartmentalization in granulocytic cells is modulated by an internal bipartite nuclear localizing sequence and nuclear factor kappa B complex formation
-
Lepley, R. A., and F. A. Fitzpatrick. 1998. 5-Lipoxygenase compartmentalization in granulocytic cells is modulated by an internal bipartite nuclear localizing sequence and nuclear factor kappa B complex formation. Arch. Biochem. Biophys. 356:71-76.
-
(1998)
Arch. Biochem. Biophys.
, vol.356
, pp. 71-76
-
-
Lepley, R.A.1
Fitzpatrick, F.A.2
-
35
-
-
0029915250
-
Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase
-
Lepley, R. A., D. T. Muskardin, and F. A. Fitzpatrick. 1996. Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase J. Biol. Chem. 271:6179-6184.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6179-6184
-
-
Lepley, R.A.1
Muskardin, D.T.2
Fitzpatrick, F.A.3
|