Smokeless tobacco potentiates VIP-induced DNA synthesis and inactivates NEP 24.11 in oral keratinocytes

American Journal of Physiology - Cell Physiology

Volumn 278, Issue 2 47-2, 2000, Pages

  Rubinstein, Israel ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

5 bromo 2' deoxyuridine; Epithelium; Hamster; Leukoplakia; Oral cancer; Oral mucosa; Peptidase; Snuff

Indexed keywords

BROXURIDINE; DNA; MEMBRANE METALLOENDOPEPTIDASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ARTICLE; DNA SYNTHESIS; ENZYME INACTIVATION; HAMSTER; KERATINOCYTE; LEUKOPLAKIA; MITOGENESIS; MOUTH CANCER; NONHUMAN; PRIORITY JOURNAL; SMOKELESS TOBACCO;

ANIMALIA; CRICETINAE; NICOTIANA TABACUM;

EID: 0034056735     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.278.2.c391     Document Type: Article

References (14)

1. Bradford, M. M. A rapid and sensitive method for quantification of microgram quantities of protein. Anal. Biochem. 71: 248-257, 1976.
2. Bunn, P. A., Jr., B. A. Helfrich, D. G. Brenner, D. C. Chan, D. J. Dykes, A. J. Cohen, and Y. E. Miller. Effects of recombinant neutral endopeptidase (EC 3.4.24.11) on the growth of lung cancer cell lines in vitro and in vivo. Clin. Cancer Res. 4: 2849-2858, 1998.
3. Burns, D. M., B. Walker, J. Gray, and J. Nelson. Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin. Br. J. Cancer 79: 214-220, 1999.
4. Cohen, A. J., P. A. Bunn, W. Franklin, C. Magill-Solc, C. Hartmann, B. Helfrich, L. Gilman, J. Folkvord, K. Helm, and Y. E. Miller. Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res. 56: 831-839, 1996.
5. Curro, D., and P. Preziosi. Involvement of vasoactive intestinal polypeptide in nicotine-induced relaxation of the rat gastric fundus. Br. J. Pharmacol. 121: 1105-1112, 1997.
6. Duggan, K. A., D. M. Jones, R. E. Davis, and G. J. MacDonald. Effect of neutral endopeptidase on plasma and tissue concentrations of vaso-active intestinal peptide. Clin. Exp. Pharmacol. Physiol. 21: 307-309, 1994.
7. Dusser, D. J., T. D. Djokic, D. B. Borson, and J. A. Nadel. Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals. J. Clin. Invest. 84: 900-906, 1989.
8. Everett, S. A., C. G. Husten, C. W. Warren, L. Crossett, and D. Sharp. Trends in tobacco use among high school students in the United States, 1991-1995. J. Sch. Health 68: 137-140, 1998.
9. Flaws, J. A., A. DeSanti, K. I. Tilly, R. O. Javid, K. Kugu, A. L. Johnson, A. N. Hirshfield, and J. L. Tilly. Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatertogenic role through evolution. Endocrinology 136: 4351-4359, 1995.
10. Ganju, R. K. M. Sunday, D. G. Tsarwhas, A. Card, and M. A. Shipp. CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation. J. Clin. Invest. 94: 1784-1791, 1994.
11. Gao, X.-P., H. Suzuki, C. O. Olopade, S. Pakhlevaniants, and I. Rubinstein. ACE and NEP modulate smokeless tobacco-induced increase in macromolecular efflux from the oral mucosa in vivo. J. Lab. Clin. Med. 130: 395-400, 1997.
12. Gao, X.-P., J. K. Vishwanatha, J. M. Conlon, C. O. Olopade, and I. Rubinstein. Mechanisms of smokeless tobacco-induced oral mucosa inflammation: role of bradykinin. J. Immunol. 157: 4624-4633, 1996.
13. Garlick, J. A., W. C. Parks, H. G. Welgus, and L. B. Taichman. Re-epithelialization of human oral keratinocytes in vitro. J. Dent. Res. 75: 912-918, 1996.
14. Grady, D., J. Greene, V. L. Ernster, P. B. Robertson, W. Hauck, D. Greenspan, J. Greenspan, and S. Silverman, Jr. Oral mucosal lesions found in smokeless tobacco users. J. Am. Dent. Assoc. 121: 117-123, 1990.