Comparison of the analytical and clinical performance characteristics of an N-MID versus an intact osteocalcin immunoradiometric assay

Clinica Chimica Acta

Volumn 294, Issue 1-2, 2000, Pages 67-76

  Takahashi, Masaaki ^a   Kushida, Kazuhiro ^a   Nagano, Akira ^a   Inoue, Tetsuo ^b  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Aoyama General Hospital   (Japan)

Author keywords

Bone formation; Bone marker; Hip fracture; Osteocalcin; Vertebral fracture

Indexed keywords

BIOCHEMICAL MARKER; OSTEOCALCIN;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; FEMALE; HIP FRACTURE; HUMAN; IMMUNORADIOMETRIC ASSAY; MAJOR CLINICAL STUDY; OSSIFICATION; OSTEOPOROSIS; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; VERTEBRA FRACTURE;

ADULT; AGED; AGED, 80 AND OVER; HIP FRACTURES; HUMANS; IMMUNORADIOMETRIC ASSAY; MALE; MIDDLE AGED; OSTEOCALCIN; PEPTIDE FRAGMENTS; POSTMENOPAUSE; PREMENOPAUSE; RADIOIMMUNOASSAY; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SPINAL FRACTURES; STATISTICS, NONPARAMETRIC;

EID: 0034056436     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(99)00251-X     Document Type: Article

References (16)

1. Hauschka P.V., Lian J.B., Cole D.E.C., Gundberg C.M. Osteocalcin and matrix gla protein: Vitamin K-dependent proteins in bone. Physiol Rev. 69:1989;990-1047.
2. Epstein S. Serum and urinary markers of bone remodeling: assessment of bone turnover. Endocr Rev. 9:1988;437-449.
3. Lian J.B., Gundberg C.M. Osteocalcin biochemical considerations and clinical applications. Clin Orthop. 226:1988;267-291.
4. Price P.A., Nishimoto S.K. Radioimmunoassay for the vitamin-K dependent protein of bone and its discovery in plasma. Proc Natl Acad Sci USA. 77:1980;2234-2238.
5. Tracy R.P., Andrianorivo A., Riggs B.L., Mann K.G. Comparison of monoclonal and polyclonal antibody-based immunoassays for osteocalcin: a study of sources of variation in assay results. J Bone Miner Res. 5:1990;451-461.
6. Masters P.W., Jones R.G., Purves D.A., Cooper E.H., Cooney J.M. Commercial assays for serum osteocalcin give clinically discordant results. Clin Chem. 40:1994;358-363.
7. Gundberg C.M., Wilson M.S., Gallop P.M., Parfitt A.M. Determination of osteocalcin in human serum: results with two kits compared with those by a well-characterized assay. Clin Chem. 31:1985;1720-1723.
8. Gundberg C.M., Weinstein R.S. Multiple immunoreactive forms of osteocalcin in uremic serum. J Clin Invest. 77:1986;1762-1767.
9. Garnero P., Grimaux M., Demiaux B., Preaudat C., Seguin P., Delmas P.D. Measurement of serum osteocalcin with a human specific two-site immunoradiometric assay. J Bone Miner Res. 7:1992;1389-1398.
10. Garnero P., Grimaux M., Seguin P., Delmas P.D. Characterization of immunoreactive forms of human osteocalcin generated in vivo and in vitro. J Bone Miner Res. 9:1994;255-264.
11. Rosenquist C., Qvist P., Bjarnason N., Cristiansen C. Measurement of a more stable region of osteocalcin in serum by ELISA with two monoclonal antibodies. Clin Chem. 10:1995;1439-1445.
12. Genant H.K., Wu C.Y., Van Kuijk C., Nevitt M.C. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 8:1993;1137-1148.
13. Takahashi M., Kushida K., Hoshino H., Aoshima H., Ohishi T., Inoue T. Effect of fracture to biochemical markers and vitamin K in acute phase of patients with hip fracture. Clin Chem. 44:1998;1583-1584.
14. Gomez B.J., Ardakani S., Ju J., et al. Monoclonal antibody assay for measuring bone specific alkaline phosphatase activity in serum. Clin Chem. 41:1995;1560-1566.
15. Parfitt A.M., Simon L.S., Villanueva A.R., Simon S.M. Procollagen type I carboxyterminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Miner Res. 2:1987;427-436.
16. Pino J.D., Martin-Gomez E., Martin-Rodriguez M., et al. Influence of sex, age, and menopause in serum osteocalcin (BGP) levels. Klin Wochenschr. 69:1991;1135-1138.