Mosaic-like distribution of endothelial cell antigens in capillaries and juxta-alveolar microvessels in the normal human lung

Pathology International

Volumn 50, Issue 2, 2000, Pages 136-141

  Kawanami, Oichi ^a   Enjing, Jin ^a   Ghazizadeh, Mohammad ^a   Fujiwara, Masakazu ^a   Jiang, Li ^a   Ohaki, Yoshiharu ^b   Gomibuchi, Makoto ^b   Takemura, Tamiko ^c  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

^c Kochi Red Cross Hospital   (Japan)

Author keywords

Confocal microscopy; Endothelial cell heterogeneity; Factor VIII related antigen; Immunofluorescence; Lung microvessels; Thrombomodulin; Von Willebrand factor

Indexed keywords

BLOOD CLOTTING FACTOR 8; THROMBOMODULIN; VON WILLEBRAND FACTOR;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; FEMALE; HAMARTOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG BLOOD VESSEL; LUNG CARCINOMA; LUNG NODULE; MALE; MICROVASCULATURE; PRIORITY JOURNAL;

ADULT; AGED; CAPILLARIES; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; LUNG; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; PULMONARY CIRCULATION; THROMBOMODULIN; VON WILLEBRAND FACTOR;

EID: 0034056387     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2000.01006.x     Document Type: Article

References (26)

1. 1 Yamamoto K, de Waard V, Fearns C, Loskutoff DJ. Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo. Stood 1998; 92: 2791-2801.
2. 2 Yamamoto M, Shimokata K, Nagura H. An immunohistochemical study on phenotypic heterogeneity of human pulmonary vascular endothelial cells. Virchows Arch. Pathol. Anat. Histopathol. 1988; 412: 479-486.
3. 3 Kawanami O, Matsuda K, Yoneyama H, Ferrans VJ, Crystal RG. Endothelial fenestration of the alveolar capillaries in interstitial fibrotic lung diseases. Acta Pathol. Jpn. 1992; 42: 177-184.
4. 4 Kawanami O, Jiang HX, Mochimaru H et al. Alveolar fibrosis and capillary alteration in experimental pulmonary silicosis in rats. Am. J. Respir. Crit. Care Med. 1955; 151: 1946-1955.
5. 5 Kasper M, Schobl R, Haroske G et al. Distribution of von Willebrand factor in capillary endothelial cells of rat lungs with pulmonary fibrosis Exp. Toxicol. Pathol. 1996; 48: 283-288.
6. 6 Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc. Natl Acad. Sci. USA 1981; 78: 2249-2252.
7. 7 Maruyama I, Bell CE, Majerus PW. Thrombomodulin is found on endothelium of arteries, veins, capillaries and lymphatics and on syncytiotrophoblast of human placenta. J. Cell Biol. 1985; 101: 363-371.
8. 8 Dittman WA, Majerus PW. Structure and function of thrombomodulin: A natural anticoagulant. Blood 1990; 95: 329-336.
9. 9 Fink LM, Eidt J, Johnson K et al. Thrombomodulin activity and localization. Int. J. Dev. Biol. 1993; 37: 221-226.
10. 10 DeBault LE, Esmon NL, Olson JR, Esmon CT. Distribution of the thrombomodulin antigen in the rabbit vasculature. Lab. Invest. 1986; 54: 172-178.
11. 11 DeBault LE, Esmon NL, Smith GP, Esmon CT. Localization of thrombomodulin antigen in rabbit endothelial cells in culture. An immunofluorescence and immunoelectron microscope study. Lab. Invest. 1986; 54: 179-187.
12. 12 Ford VA, Stringer C, Kennel SJ. Thrombomodulin is preferentially expressed in Balb/c Lung microvessels. J. Biol. Chem. 1992; 267: 5446-5450.
13. 13 Tamura A, Matsubara O, Hirokawa K, Aoki N. Detection of thrombomodulin in human lung cancer cells. Am. J. Pathol. 1993; 142: 79-85.
14. 14 Nakajima M, Kawanami O, Jin EJ et al. Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways. Pathol. Int. 1998; 48: 944-953.
15. 15 Cudkowicz L. Bronchial arterial circulation in man: Normal anatomy and responses to disease. Pulmonary vascular diseases. In: Moser KM, ed., Lenfant C, exec. ed. Lung Biology in Health and Disease, Vol. 14, Marcel Dekker Inc., New York, 1979; 111-232.
16. 16 Charan NB, Turk GM, Dhand R. Gross and subgross anatomy of bronchial circulation in sheep. J. Appl. Physiol. 1984; 57: 658-664.
17. 17 Deffebach MK, Charan NB, Lakshminarayan S, Butler J. The bronchial circulation. Small, but a vital attribute of the lung. Am. Rev. Respir. Dis. 1987; 135: 463-481.
18. 18 Reidy MA, Chopek M, Chao S, McDonald T, Schwartz SM. Injury induces increase of von Willebrand factor in rat endothelial cells. Am. J. Pathol. 1989; 134: 857-864.
19. 19 Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J. Exp. Med. 1986; 163: 740-745.
20. 20 Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J. Clin. Invest. 1987; 79: 124-130.
21. 21 Buck CA, Edelman JM, Buck CE, Kennedy G, Baldwin HS. Expression patterns of adhesion receptors in the developing mouse lung: Functional implications. Cell Adhes. Commun. 1996; 4: 69-87.
22. 22 Gerritsen ME, Bloor CM. Endothelial cell gene expression in response to injury. FASEB J. 1993; 7: 523-532.
23. 23 Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J. Cell Biol. 1997; 138: 1117-1124.
24. 24 Renkin EM. Cellular and intercellular transport pathways in exchange vessels. Am. Rev. Respir. Dis. 1992; 146: S28-S31.
25. 25 Schraufnagel DE. Corrosion casting of the lung for scanning electron microscopy In: Schraufnagel DE, ed. Electron Microscopy of the Lung. Marcel Dekker Inc., New York, 1990; 257-297.
26. 26 Peao MND, Aguas AP, de Sa AC, Grande NR. Neoformation of blood vessels in association with rat lung fibrosis induced by bleomycin. Anat. Rec. 1994; 238: 57-67.