A trichothecene efflux pump encoded by Tri102 in the biosynthetic gene cluster of Fusarium graminearum

Journal of Antibiotics

Volumn 53, Issue 2, 2000, Pages 196-200

  Wuchiyama, Junko ^a   Kimura, Makoto ^b   Yamaguchi, Isamu ^a  

^a RIKEN   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUREOBASIDIN A; BLASTICIDIN S; DACTINOMYCIN; FUSARENON X; PROTEIN SYNTHESIS INHIBITOR; TRICHOTHECENE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DNA HYBRIDIZATION; FUSARIUM GRAMINEARUM; GENE; GENE ISOLATION; GENETIC ANALYSIS; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; RNA HYBRIDIZATION;

FUSARIUM GRAMINEARUM;

EID: 0034054072     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.196     Document Type: Article

References (14)

1. UENO, Y.; M. NAKAJIMA, K. SAKAKI, K. ISHII, N. SATO & N. SHIMADA: Comparative toxicology of trichothecene mycotoxins: Inhibition of protein synthesis in animal cells. J. Biochem. 74: 285-296, 1973
2. KIMURA, M.; I. KANEKO, M. KOMIYAMA, A. TAKATSUKI, H. KOSHINO, K. YONEYAMA & I. YAMAGUCHI: Trichothecene 3-O-acetyltransferase protects both the producing organism and transformed yeast from related mycotoxins. Cloning and characterization of Tri101. J. Biol. Chem. 273: 1654-1661, 1998
3. DESJARDINS, A. E.; T. M. HOHN & S. P. MCCORMICK: Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol. Rev. 57: 595-604, 1993
4. HOHN, T. M.; S. P. MCCORMICK & A. E. DESJARDINS: Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr. Genet. 24: 291-295, 1993
5. ALEXANDER, N. J.; T. M. HOHN & S. P. MCCORMICK: The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis. Appl. Environ. Microbiol. 64: 221-225, 1998
6. PAULSEN, I. T.; M. H. BROWN & R. A. SKURRAY: Proton-dependent multidrug efflux systems. Microbiol. Rev. 60: 575-608, 1996
7. EHRENHOFFER-MURRAY, A. E.; F. E. WÜGLER & C. SENGSTAG: The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily. Mol. Gen. Genet. 244: 287-294, 1994
8. PITKINM, J. W.; D. G. PANACIONE & J. D. WALTON: A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology 142: 1557-1565, 1996
9. KYTE, J. & R.F DOOLITTLE: A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105-132, 1982
10. KIMURA, M.; Y. SHINGU, K. YONEYAMA & I. YAMAGUCHI: Features of Tri101, the trichothecene 3-O-acetyltransferase gene, related to the self-defense mechanism in Fusarium graminearum. Biosci. Biotechnol. Biochem. 62: 1033-1036, 1998
11. + gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe. Biosci. Biotechnol. Biochem. 62: 390-392, 1998
12. ALTSCHUL, S. F.; T. L. MADDEN, A. A. SCHÄFER, J. ZHANG, Z. ZHANG, W. MILLER & D. J. LIPMAN: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402, 1997
13. KIMURA, M.; T. KAMAKURA, Q. Z. TAO, I. KANEKO & I. YAMAGUCHI: Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae. Mol. Gen. Genet. 242: 121-129, 1994
14. THOMPSON, J. D.; D. G. HIGGINS & T. J. GIBSON: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22: 4673-4680, 1994