Effect of loperamide on Na+/D-glucose cotransporter activity in mouse small intestine

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 6, 2000, Pages 679-686

  Klaren, P H M ^a,c   Giesberts, A N ^a   Chapman, J ^a   White, S J ^a   Taylor, C J ^b   Hardcastle, P T ^a   Hardcastle, J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN INHIBITOR; GLUCOSE TRANSPORTER; LOPERAMIDE; PHLORIZIN; SODIUM ION;

ARTICLE; DRUG UPTAKE; INHIBITION KINETICS; MALE; MEMBRANE VESICLE; MOUSE; NONHUMAN; SMALL INTESTINE;

EID: 0034053715     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774354     Document Type: Article

References (34)

1. + exchanger by loperamide. J. Pharmacol. Exp. Ther. 243: 150-154
2. Baxter, P., Goldhill, J., Hardcastle, J., Hardcastle, P. T., Taylor, C. J. (1990) Enhanced intestinal glucose and alanine transport in cystic fibrosis. Gut 31: 817-820
3. Binder, H. J., Laurenson, J. P., Dobbins, J. W. (1984) Role of opiate receptors in regulation of enkephalin stimulation of active sodium and chloride absorption. Am. J. Physiol. 247: G432-G436
4. Brayden, D., Moriarty, D., Baird. A. (1997) A novel in vitro electrophysiological bioassay for transport of loperamide across intestinal epithelia. Pharm. Res. 14: 942-945
5. Chang, E. B., Brown, D. R., Wang, N. S., Field, M. (1986) Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide. J. Clin. Invest. 78: 281-287
6. Cornish-Bowden, A. (1995) Fundamentals of Enzyme Kinetics. Portland Press Ltd, London, pp 95-102
7. Dahlqvist, A. (1964) Method for assay of intestinal disaccharidases. Anal. Biochem. 7: 18-25
8. 2+-or cAMP-mediated secretion in rat colon. Eur. J. Pharmacol. 152: 217-225
9. Ferguson, G. A. (1971) Statistical Analysis in Psychology and Education. Third edn, McGraw-Hill, New York, pp 155-157
10. Gaginella, T. S., Rimele, T. J., Wietecha, M. (1983) Studies on rat intestinal epithelial cell receptors for serotonin and opiates. J. Physiol. 335: 101-111
11. George, S. G., Kenny, A. J. (1973) Studies on the enzymology of purified preparations of brush border from rabbit kidney. Biochem. J. 134:43-57
12. Hardcastle, J., Hardcastle, P. T., Read, N. W., Redfern, J. S. (1981) The action of loperamide in inhibiting prostaglandin-induced intestinal secretion in the rat. Br. J. Pharmacol. 74: 563-569
13. Hardcastle, J., Hardcastle, P. T., Cookson, J. (1986) Inhibitory actions of loperamide on absorptive processes in rat small intestine. Gut 27: 686-694
14. Hardcastle, J., Hardcastle, P. T., Taylor, C. J. (1994) Loperamide inhibits the enhanced intestinal glucose absorption of cystic fibrosis in vitro. Pediatr. Res. 35: 354-356
15. 2+-ATPaSe activity of rabbit intestinal brush border membrane with changes in fluidity of its membrane lipid bilayer. J. Membro. Biol. 146: 193-199
16. Kromer, W. (1995) Unexpected prosecretory action component of loperamide at μ-opioid receptors in the guinea-pig colonic mucosa in vitro. Br. J. Pharmacol. 114: 739-744
17. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriofage T4. Nature 227:680-685
18. Leatherbarrow, R. J. (1987) Enzfitter: a non-linear regression data analysis program for the IBM PC. Elsevier Science Publishers BV, Amsterdam
19. Merritt, J. F., Brown, B. L., Tomlinson, S. (1982) Loperamide and calmodulin. Lancet 1: 283
20. Mircheff, A. K., Wright, E. M. (1976) Analytical isolation of plasma membranes of intestinal epithelial cells: identification of Na,K-ATPase rich membranes and the distribution of enzyme activities. J. Membrane Biol. 28: 309-333
21. Miyazaki, H., Nambu, K., Hashimoto, M. (1982) Loperamide in rat intestines: a unique disposition. Life Sci. 30: 2203-2206
22. Okhuysen, P. C., DuPont, H. L., Ericsson, C. D., Marani, S., Martinez-Sandoval, F. G., Olesen, M. A., Ravelli, G. P. (1995) Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial. Clin. Infect. Dis. 21: 341-344
23. Pennington, R. J. (1961) Biochemistry of dystrophic muscle mitochondrial succinate tetrazolium reductase and adenosine triphosphatase. Biochem. J. 80: 649-654
24. Press, A. G., Ewe, K., Schmidt, J., Junge, H. (1991) Effect of loperamide on jejunal electrolyte and water transport, prostaglandin E2-induced secretion and intestinal transit time in man. Eur. J. Clin. Pharmacol. 41: 239-243
25. Proulx, P. (1991) Structure-function relationships in intestinal brush border membranes. Biochim. Biophys. Acta 1071: 255-271
26. Reynolds, I. J., Gould, R. J., Snyder, S. H. (1984) Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. J. Pharmacol. Exp. Ther. 231: 628-632
27. Schulzke, J. D., Fromm, M., Riecken, E. O., Reutter, W. (1990) Enkephalin affects ion transport via the enteric nervous system in guinea-pig ileum. Eur. J. Clin. Invest. 20: 182-191
28. Scully, R. R., Dedman, J. R., Schultz, S. G. (1988) Localization of calmodulin in the enterocyte of Necturus small intestine. J. Cell Sci. 91: 541-547
29. Steel, A., Hediger, M. A. (1998) The molecular physiology of sodium-and proton-coupled solute transporters. Physiol. Sci. 13: 123-131
30. Stoll, R., Stern, H., Ruppin, H., Domschke, W. (1987) Effect of two potent calmodulin antagonists on calcium transport of brush border and basolateral vesicles from human duodenum. Aliment. Pharmacol. Ther. 1: 415-424
31. Stoll, R., Ruppin, H., Domschke, W. (1988) Calmodulin-mediated effects of loperamide on chloride transport by brush border membrane vesicles from human ileum. Gastroenterology 95: 69-76
32. Theodorou, V., Fioramonti, J., Hachet, T., Bueno, L. (1991) Absorptive and motor components of the antidiarrhoeal action of loperamide: an in vivo study in pigs. Gut 32: 1355-1359
33. van Neuten, J. M., Janssen, P. A. J., Fontaine, J. (1974) Loperamide (R 18553), a novel type of anti-diarrhoeal agent. III. In vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneim. forsch 24: 1641-1645
34. Zavecz, J. H., Jackson, T. E., Limp, G. L., Yellin, T. O. (1982) Relationship between anti-diarrheal activity and binding to calmodulin. Eur. J. Pharmacol. 78: 375-377