Immunoassays for pentamidine and related compounds: Development of a facile inhibitory ELISA suitable for clinical use

Journal of Clinical Laboratory Analysis

Volumn 14, Issue 2, 2000, Pages 73-82

  Reisner, Howard M ^a   Gray, Danny R ^a   Jones, Susan K ^a   Rose, Beate G ^a   Tidwell, Richard R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Dicationic molecules; ELISA; Immunoassay; Leishmania mexicana amazoniensis; Pentamidine; Pneumocystis carinii

Indexed keywords

PENTAMIDINE; PENTAMIDINE DERIVATIVE;

ARTICLE; DRUG CONJUGATION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HAPTENS; IMMUNE SERA; IMMUNIZATION; MALEIC ANHYDRIDES; MICE; OVALBUMIN; PENTAMIDINE; RABBITS; SENSITIVITY AND SPECIFICITY; SULFHYDRYL COMPOUNDS;

CRYPTOSPORIDIUM PARVUM; FILOBASIDIELLA NEOFORMANS; LEISHMANIA AMAZONENSIS; LEISHMANIA MEXICANA; PNEUMOCYSTIS CARINII;

EID: 0034052785     PISSN: 08878013     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2825(2000)14:2<73::AID-JCLA7>3.0.CO;2-G     Document Type: Article

References (38)

1. Bell CA, Hall JE, Kyle DE, et al. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob Agents Chemother 1990;34:1381.
2. Tidwell RR, Jones SK, Naiman NA, Berger LC, Brake WB, Dykstra, CC, Hall JE. Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 1993;37:1713.
3. Hall JE, Kerrigan JE, Ramachandran K, et al. Anti-pneumocystis activities of aromatic diamidoxime prodrugs. Antimicrob Agents Chemother 1998;42:666.
4. Del Poeta M, Schell WA, Dykstra CC, et al. Structure-in vitro activity relationships of pentamidine analogues and dicationic-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother 1998a;42:2495.
5. Schoenbach EB, Greenspan EM. The pharmacology, mode of action and therapeutic potentialities of stilbamidine, pentamidine, propamidine, and other aromatic diamidines - A review. Medicine 1948;27:327.
6. Sands M, Kron MA, Brown RB. Pentamidine: a review. Rev Infect Dis 1985;7:625.
7. Tidwell RR, Jones SK, Geratz JD, Ohemeng KA, Bell CA, Berger BJ, Hall JE. Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia. Ann NY Acad Sci 1990b;616:421.
8. Berger BJ, Naiman NA, Hall JE, Peggins J, Brewer TG, Tidwell RR. Primary and secondary metabolism of pentamidine by rats. Antimicrob and Chemother 1992b;36:1825.
9. Bronner U, Ericsson O, Nordin J, et al. Metabolism is an important route of pentamidine elimination in the rat: disposition of 14C-pentamidine and identification of metabolites in urine using liquid chromatography-tandem mass spectrometry. Pharmacol Toxicol 1995;77:114.
10. Ioannidis JPA, Capelleri JC, Skolnik PR, Lau J, Sacks HS. A meta-analysis of the relative efficacy and toxicity of Pneumocystis carinii prophylactic regimens. Arch Intern Med 1996;156:177.
11. Berman JD. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last ten years. Clin Infect Dis 1997;24:684.
12. Machado CM, Macedo MCA, Medeiros RSS, et al. Primary Pneumocystis carinii prophylaxis with aerosolized pentamidine after bone marrow transplantation. Acta Haematol 1998;99:54.
13. Jones JL, Hanson DL, Alderton DL, Fleming PL, Kaplan JE, Ward J. Surveillance for AIDS-Defining Opportunistic Illnesses, 1992-1997. In: CDC Surveillance Summaries. MMWR 1999;48:1.
14. Assan R, Perronne C, Assan D, Chotard L, Mayaud C, Matheron S, Zucman D. Pentamidine-induced derangements of glucose homeostasis: Determinant roles of renal failure and drug accumulation - A study of 128 patients. Diabetes Care 1995;18:47.
15. O'Brien JG, Dong BJ, Coleman RL, Gee L, Balano KB. A 5-year retrospective review of adverse drug reactions and their risk factors in human immunodeficiency virus-infected patients who were receiving intravenous pentamidine therapy for Pneumocystis carinii pneumonia. Clin Infect Dis 1997;24:854.
16. Edwards KJ, Jenkins TC, Neidle S. Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties. Biochemistry 1992;31:7104.
17. Tidwell RR. Bell CA. Pentamidine and Related Compounds in the Treatment of Pneumocystis carinii Infection. In: Walzer PD, editor. Pneumocystis carinii Pneumonia. 2nd ed., Revised and Expanded. New York: Marcel Dekker, Inc.; 1994. p 561.
18. Tuttle RH, Hall JE, Tidwell RR. High-performance liquid chromatographic assay detects pentamidine metabolism by Fisher rat liver microsomes. J Chromatogr B Biomed Sci App 1997;688:319.
19. Berger BJ, Reddy VV, Le ST, Lombardy RJ, Hall JE, Tidwell RR. Hydroxylation of pentamidine by rat liver microsomes. J Pharm Exp Ther 1991;256:883.
20. Wood DH, Hall JE, Rose BG, Tidwell RR. 1.5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H] idazoxan binding to imidazoline I2 binding sites. Eur J Pharmacol 1998;353:97.
21. Berger BJ, Naiman NA, Hall JE, Peggins J, Brewer TG, Tidwell RR. Problems and pitfalls in the assay of pentamidine. Implications for clinical use. Clin Pharmacokinet 1992a;22:163.
22. Nordin J, Wikström I, Bronner U, Gustafsson LL, Ericsson O. Liquid chromatography tandem mass spectrometry applied to a study of the metabolism of pentamidine - Discussion of possibilities and problems. J Chromatogr A 1997;777:73.
23. Lidman C, Bronner U, Gustafsson LL, Rombo L. Plasma pentamidine concentrations vary between individuals with Pneumocystis carinii pneumonia and the drug is actively secreted by the kidney. J Antimicrob Chemother J Chromatogr A 1994;33:803.
24. Sattler FR, Jelliffe RW. Pharmacokinetic and Pharmacodyanmic Considerations for Drug Dosing in the Treatment of Pneumocystis carinii Pneumonia. In: Walzer PD, editor, Pneumocystis carinii Pneumonia. 2nd ed., Revised and Expanded. New York: Marcel Dekker, Inc.; 1994. p 467.
25. Tidwell RR, Jones SK, Geratz JD, Ohemeng KA, Cory M, Hall JE. Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J Med Chem 1990a;33:1252.
26. Ashley JN, Barber HJ, Ewins AJ, Newberry G, Self ADH. J Chem Soc 1942;103.
27. Berg SS, Newberry G. J Chem Soc 1949.
28. Parrish RF, Strauss JW, Paulson JD, Polakoski KL, Tidwell RR, Geratz JD, Stevens FM. Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives. J Med Chem 1978;21:1132.
29. Blättler WA, Kuenzi BS, Lambert JM, Senter PD. New heterobifunctional protein cross-linking reagent that forms an acid-labile link. Biochem 1985;24:1517.
30. Aithal HN, Knigge KM, Kartha S, Czyzewski AE, Toback FG. An alternate method utilizing small quantities of ligand for affinity purification of monospecific antibodies. J Immunol Methods 1988;112:63.
31. Levin LG, Rudd A, Bletsa A, Reisner HM. Expression of IL-8 mRNA by cells of the odontoblast layer in-vivo. Eur J Oral Sci 1999;107:131.
32. Hermanson GT. Types of Immunogen Carriers. In: Bioconjugate Techniques. San Diego: Academic Press; 1996. p 421.
33. Patrick DA, Boykin DW, Wilson WD, et al. Anti-Pneumocystic carinii pneumonia activity of dicationic carbazoles. Eur J Med Chem 1997; 32:781.
34. Del Poeta M, Dykstra CC, Jones SK, Tidwell RR, Kumar A, Boykin DW, Perfect JR. In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrob Agents Chemother 1998b;42:2503.
35. Hopkins KT, Wilson DW, Bender BC, et al. Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. J Med Chem 1998;41:3872.
36. Kitagawa T, Fujiwara K, Tomonoh S, Takahashi K, Koida M. Enzyme immunoassays of kanamycin group antibiotics with high sensitivities using anti-kanamycin as a common antiserum: reasoning and selection of a heterologous enzyme label. J Biochem 1983;94:1165.
37. Erlanger BF. The Preparation of Antigenic Hapten-Carrier Cojugates: A Survey. In: Van Vunakis H. and Langone JL, editors. Immunochemical Techniques Part A. New York: Academic Press; 1980. p 85.
38. Berger BJ, Lombardy RJ, Marbury DG, Bell CA, Dykstra CC, Hall JE, Tidwell RR. Metabolic N-hydroxylation of pentamidine in vitro. Antimicrob Agents Chemother 1990;34:1678.