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Volumn , Issue 3, 2000, Pages 341-342

Microwave-assisted regioselective synthesis of β-aminoketones via the Mannich reaction

Author keywords

Aminoketones; Diamines; Mannich reactions; Microwave irradiation

Indexed keywords

AMINOKETONE;

EID: 0034050043     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (29)
  • 2
    • 85067856671 scopus 로고
    • Tramontini, M., Synthesis 1973, 703; Tramontini, M., Angiolini, L., Tetrahedron 1990, 46, 1791.
    • (1973) Synthesis , pp. 703
    • Tramontini, M.1
  • 4
    • 0000733768 scopus 로고
    • Eds. Trost, & Fleming., Pergamon, Oxford
    • Kleinman, E. F. in Comprehensive Organic Synthesis, vol. 2, Eds. Trost, & Fleming., Pergamon, Oxford 1991, p. 893.
    • (1991) Comprehensive Organic Synthesis , vol.2 , pp. 893
    • Kleinman, E.F.1
  • 24
    • 0004521718 scopus 로고
    • Mannich, C., Abdullah, S.M., Ber. 1935, 68, 113; Chem. Abstr. 1935, 2535.
    • (1935) Chem. Abstr. , pp. 2535
  • 25
    • 0343695023 scopus 로고    scopus 로고
    • note
    • In a typical case a mixture of acetophenone (0.60g, 5 mmol), paraformaldehyde (0.30g, 10 mmol), diethylaminc hydrochloride (0.55g, 5 mmol) and ethanol (5ml) were taken in an Erlenmeyer flask and placed in a microwave oven and irradiated for 5 min, (monitored by TLC). The reaction mixture was allowed to cool and filtered. Removal of solvent and purification of the residue by column chromatography on silica gel gave diethyl(2-benzoyl ethyl)amine hydrochloride mp. 108°C in 65% yield. Other β-amino ketones (entry 5,6,8-12) were prepared similarly using ethanol as solvent.
  • 27
    • 85040166995 scopus 로고
    • Mannich, C., Braun, R., Ber. 1920, 53B, 1874; Chem. Abstr. 1921, 15, 861.
    • (1920) Ber. , vol.53 B , pp. 1874
    • Mannich, C.1    Braun, R.2
  • 28
    • 0342824558 scopus 로고
    • Mannich, C., Braun, R., Ber. 1920, 53B, 1874; Chem. Abstr. 1921, 15, 861.
    • (1921) Chem. Abstr. , vol.15 , pp. 861


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.