Formation of antigenic quinolone photoadducts on Langerhans cells initiates photoallergy to systemically administered quinolone in mice

Journal of Investigative Dermatology

Volumn 114, Issue 3, 2000, Pages 569-575

  Ohshima, Akihiro ^a   Seo, Naohiro ^a   Takigawa, Masahiro ^a   Tokura, Yoshiki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Fleroxacin; Fluoroquinolone

Indexed keywords

FLEROXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL CELL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG HYPERSENSITIVITY; IMMUNOPATHOLOGY; LANGERHANS CELL; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHOTOALLERGY; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION;

EID: 0034049704     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00918.x     Document Type: Article

References (26)

1. Casares S, Inaba K, Brumeanu TD, Steinman RM, Bona CA: Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J Exp Med 186:1481-1486, 1997
2. Domagala JM: Structure-activity and structure-side-effect relationship for the quinolone antibacterials. J Antimicrob Chemother 33:685-706, 1994
3. Ferguson J: Fluoroquinolone photosensitization: a review of clinical and laboratory studies. Photochem Photobiol 62:954-958, 1995
4. Ferguson J, Johnson BE. Recently developed photosensitizing agents. In: Urbach F (ed.). Biological Responses to Ultraviolet A Radiation. Overland Park, KS: Valdenmar Publishing Company, 1992, pp. 107-119
5. Giudici PA, Maguire HC Jr: Experimental photoallergy to systemic drugs. J Invest Dermatol 85:207-211, 1985
6. Horio T, Miyauchi H, Asada Y, Aoki Y, Harada M: Phototoxicity and photoallergenicity of quinolones in guinea pigs. J Dermatol Sci 7:130-135, 1994
7. Iwamoto Y, Itoyama T, Yasuda K, et al: Photodynamic deoxyribonucleic acid (DNA) strand breaking activities of enoxacin and afloqualone. Chem Pharm Bull 40:1868-1870, 1992
8. Izu R, Gardeazabal J, Gonzalez M, Landa N, Raton JA, Diaz-Perez JL: Enoxacin-induced photosensitivity: study of two cases. Photodermatol Photoimmunol Photomed 9:86-88, 1992
9. Kang JS, Kim TH, Park KB, Chung BH, Youn JI: Enoxacin photosensitivity. Photodermatol Photoimmunol Photomed 9:159-161, 1993
10. Katayama I, Matsunaga H, Yokozeki H, Nishioka K: Blockade of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) down-regulates induction of contact photosensitivity by haptenated epidermal cells. Br J Dermatol 136:846-852, 1997
11. Kawabe Y, Mizuno N, Sakakibara S: Photoallergic reaction induced by enoxacin. Photodermatology 6:57-60, 1989
12. Kurumaji Y, Shono M: Scarified photopatch testing in lomefloxacin photosensitivity. Contact Dermatitis 26:5-10, 1992
13. Matsumoto M, Kitajima K, Nagano H, Matsubara S, Yokota T: Photostability and biological activity of fluoroquinolones substituted at the 8-position after UV irradiation. Antimicrob Agents Chemother 37:1715-1719, 1992
14. Nishijima T, Tokura Y, Imokawa G, Seo N, Furukawa F, Takigawa M: Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption. J Invest Dermatol 109:175-182, 1997
15. Ohshima A, Tokura Y, Wakita H, Furukawa F, Takigawa M: Roxithromycin down-modulates antigen-presenting and interleukin-1β-producing abilities of murine Langerhans cells. J Dermatol Sci 17:214-222, 1998
16. Okamoto H, Kripke ML: Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms. Proc Natl Acad Sci (USA) 84:3841-3845, 1987
17. Tiefenbacher EM, Haen E, Przybilla B, Kurz H: Photodegradation of some quinolones used as antimicrobial therapeutics. J Pharm Sci 83:463-467, 1994
18. Tokura Y: Quinolone photoallergy: photosensitivity dermatitis induced by systemic administration of photohaptenic drugs. J Dermatol Sci 18:1-10, 1998
19. Tokura Y, Satoh T, Yamada M, Takigawa M: Genetic control of contact photosensitivity to tetrachlorosalicylanilide. II. Igh complex controls the sensitivity induced by photohapten-modifiedspleen cells but not epidermal cells. Cell Immunol 135:195-207, 1991
20. Tokura Y, Yagi J, O'Malley M, Lewis JM, Takigawa M, Edelson RL, Tigelaar RE: Superantigenic staphylococcal exotoxins induce T cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T cell-activating cytokines. J Invest Dermatol 102:31-38, 1994
21. Tokura Y, Iwamoto Y, Mizutani K, Takigawa M: Sparfloxacin phototoxicity: potential photoaugmentation by ultraviolet A and B sources. Arch Dermatol Res 288:45-50, 1996a
22. Tokura Y, Nishijima T, Yagi H, Furukawa F, Takigawa M: Photohaptenic properties of fluoroquinolones. Photochem Photobiol 64:838-844, 1996b
23. Tokura Y, Seo N, Yagi H, Furukawa F, Takigawa M: Cross-reactivity in murine fluoroquinolone photoallergy: exclusive usage of TCR Vβ13 by immune T cells that recognize fluoroquinolone-photomodified cells. J Immunol 160:3719-3728, 1998
24. Wagai N, Tawara K: Quinolone antibacterial-agent-induced cutaneous phototoxicity: ear swelling reactions in Balb/c mice. Toxicol Lett 58:215-223, 1991
25. Yoshida Y, Moroi R: Photodegradation products of levofloxacin in aqueous solution, Arzneimittel-Forschung 43:601-606, 1993
26. Yoshizawa M, Hashimoto A, Asai T: Photosensitivity induced by lomefloxacin. Hifubyou-Shinryou 14:1085-1088, 1992