Brittle-ductile transitions in sucrose and the influence of lateral stresses during compaction

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 2, 2000, Pages 147-150

  Roberts, R J ^a   Rowe, R C ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SUCROSE;

ARTICLE; COMPRESSION; DRUG CONFORMATION; DRUG STABILITY; DRUG STRUCTURE; PHASE TRANSITION;

EID: 0034049589     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001773788     Document Type: Article

References (15)

1. Duncan-Hewilt, W. C., Weatherly, G. C. (1989) Evaluating the fracture toughness of sucrose crystals using microindentation techniques. Pharm. Res. 6: 373-378
2. Duncan-Hewitt, W. C., Weatherly, G. C. (1990a) Modeling the uniaxial compaction of pharmaceutical powders using the mechanical properties of single crystals. I: Ductile materials. J. Pharm. Sci. 79: 147-152
3. Duncan-Hewitt, W. C., Weatherly, G. C. (1990b) Modeling the uniaxial compaction of pharmaceutical powders using the mechanical properties of single crystals. II: Brittle materials. J. Pharm. Sci. 79: 273-278
4. Heckel, R. W. (1961a) Density-pressure relationships in powder compaction. Trans. Metall. Soc. A.I.M.E. 221: 671-675
5. Heckel, R. W. (1961b) An analysis of powder compaction phenomena. Trans. Metall. Soc. A.I.M.E. 221: 1001-1008
6. Ho, T., Hersey, J. A. (1979) Granulation using the agglomerative phase of comminution. Powder Tech. 23: 191-195
7. Kendall, K. (1978a) The impossibility of comminuting small particles by compression. Nature (London) 272: 710-711
8. Kendall, K. (1978b) Complexities of compression failure. Proc. R. Soc. Lond. A361: 245-263
9. Perry, R. H., Green, D. W. (1988) Perry's Chemical Engineers Handbook. Sixth Edition, McGraw-Hill, New York, pp 8.9-8.72
10. Roberts, R. J., Rowe, R. C. (1985) The effect of punch velocity on the compaction of a variety of materials. J. Pharm. Pharmacol. 37: 377-384
11. Roberts, R. J., Rowe, R. C. (1987) Brittle/ductile behaviour in pharmaceutical materials used in tabletting. Int. J. Pharm. 36: 205-209
12. Roberts, R. J., Rowe, R. C., Kendall, K. (1989) Brittle-ductile transitions in die-compaction of sodium chloride. Chem. Eng. Sci. 44: 1647-1651
13. 1C) of pharmaceutical powders using three point single edge notched beam (SENB) testing. Int. J. Pharm. 91: 173-182
14. Roberts, R. J., Rowe, R. C., Kendall, K. (1997) The influence of lateral stresses on brittle-ductile transitions in die-compaction of sodium chloride. J. Mat. Sci. 32: 4183-4187
15. Rowe, R. C., Roberts, R. J. (1996) Mechanical properties. In: Alderborn, G., Nystrom, C., (eds) Pharmaceutical Powder Compaction Technology. Marcel Dekker Inc., New York, pp 283-322