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19
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0013654561
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-
note
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14 What matters is the relative topicity of the hydrogen atoms at C-3 to the stereocenters at C-2 and C-4. Assigning the hydrogen atom at C-3 as pro-R or pro-S therefore only makes sense if the configuration at C-2 and C-4 is defined, which has been arbitrarily done in the manner shown in the heading of the table.
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-
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20
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-
0013635350
-
-
note
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(pro-R) to H-2 = 12.1 and to H-4 = 1.5 Hz. The experimentally found coupling constants of 10.7 and 3.3 Hz, respectively, represent the population weighted average in solution.
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21
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0001000382
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16 T. Hintermann, K. Gademann, B. Jaun and D. Seebach, Helv. Chim. Acta, 1998, 81, 983; S. Hanessian, X. Luo and R. Schaum,Tetrahedron Lett., 1999, 40, 4925.
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18 L. Lapatsanis, G. Milias, K. Froussios and M. Kolovos, Synthesis, 1983, 671.
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