Blood pressure depression by the fruit juice of Carica Papaya (L.) in renal and DOCA-induced hypertension in the rat

Phytotherapy Research

Volumn 14, Issue 4, 2000, Pages 235-239

  Eno, A E ^a   Owo, O I ^a   Itam, E H ^a   Konya, R S ^b  

^a UNIVERSITY OF CALABAR   (Nigeria)

^b University of Portharcourt   (Nigeria)

Author keywords

Alpha adrenoceptors; Antihypertensive; Blood pressure; Carica papaya; Fruit; Vasodilatation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ATROPINE; CARICA PAPAYA EXTRACT; DEOXYCORTICOSTERONE ACETATE; HYDRALAZINE; NORADRENALIN; PHENTOLAMINE; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG SCREENING; EXTRACTION; FRUIT JUICE; HEART RATE; HYPERTENSION; MALE; NONHUMAN; RABBIT; RAT; RENOVASCULAR HYPERTENSION; VASODILATATION;

ANIMALS; ARTERIES; BLOOD PRESSURE; DESOXYCORTICOSTERONE; HEART RATE; HYPERTENSION; HYPERTENSION, PORTAL; MALE; MICE; MUSCLE CONTRACTION; PLANT EXTRACTS; PLANTS, MEDICINAL; RABBITS; RATS; RATS, WISTAR;

CARICA PAPAYA; ORYCTOLAGUS CUNICULUS; RATTUS NORVEGICUS;

EID: 0034048869     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1573(200006)14:4<235::AID-PTR574>3.0.CO;2-G     Document Type: Article

References (11)

1. Ampofo, C. (1977). Plants that heal. World Health 26, 30.
2. Bouquet, A. (1969). Feticheur et Medicine Traditionelle du Congo (Branzzaville), pp. 48-53. ORSTOM, Paris.
3. Bouquet, A., and Bebray, M. (1974). Les plants medicinales de la Cote d'voire, p. 64. ORSTOM, Paris.
4. Bowman, W. C., and Rand, M. J. (1980). In Textbook of Pharmacology, 2nd edn, pp. 10-21-24. Blackwell Scientific, London.
5. Grobecker, H., Saavedra, J. M., Roiser, M. F., Kopin, I. J., and Axelred, J. (1976). Peripheral and central catecholaminergic neurons in genetic and experimental hypertensive rats. Clin. Sci. Mol. Med. 51, 377.
6. Kamanyi, A., and Eta, J. N. (1992). Relaxant effect of the aqueous extract of Carica papaya (L) on the uterine smooth muscle of the rat. Nig. J. Physiol. Sci. 8, 78-82.
7. Litchfield, J. T., and Wilcoxon, F. W. J. (1949). A simplified method of evaluating dose-effect experiments. J. Pharmac. Exp. Ther. 96, 99.
8. McDevitt, D. G. (1979). Adrenoceptor blocking drugs: clinical pharmacology and therapeutic use. Drugs 17, 267-288.
9. Osunkwo, U. A., and Eferakeya, A. E. (1987). Plasma catecholamines levels during development of DOCA, renal and spontaneous hypertension in rats. Med. Sci. Res. 15, 971-972.
10. Osunkwo, U. A., and Eferakeya, A. E. (1995). Attenuated hypothalamic secondary prossor responsiveness and the effect of gallopamil or hydrallazine in DOCA-salt and renal hypertensive rats. Nig. J. Physiol. Sci. 11, 1-5.
11. Sofowora, A. (1989). The State of Medicinal Plants Research in Nigeria, pp. 80-91. John Wiley and Sons, New York and Spectrum Books, Ibadan.