Investigation of moisture scavengers in pressurized metered-dose inhalers

S.T.P. Pharma Sciences

Volumn 10, Issue 3, 2000, Pages 243-250

  Williams III, R O ^b   Hu, C ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b DuPont Pharmaceuticals   (United States)

Author keywords

Alumina; Humidity scavengers; Hydroxypropylmethyl cellulose; Pressurised metered dose inhalers; Silica

Indexed keywords

ALUMINUM; HYDROXYPROPYLMETHYLCELLULOSE; SCAVENGER; SILICA GEL;

AEROSOL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; HUMIDITY; METERED DOSE INHALER; MOISTURE;

EID: 0034048431     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. REYNOLDS J.M. and McNAMARA D.P. - Model for moisture transport into inhalation aerosols. - Pharm. Res., 13, 5, 809-811, 1996.
2. WILLIAMS III R.O. and HU C. - Moisture uptake and its influence on pressurized metered-dose inhalers. - Pharm. Dev. Tech., in press.
3. BYRON P.R. - Pulmonary targeting with aerosols. - Pharm. Tech., 42-56, 1987.
4. MOLINA M.J. and ROWLAND F.S. - Stratospheric sink for chlorofluoromethanes: chlorine atomc-atalysed destruction of ozone. - Nature, 249, 810-812, 1974.
5. LEACH C.L. - Approaches and challenges to use freon propellant replacements. - Aerosol Sci. Tech., 22, 328-334, 1995.
6. HARRISON L.I. et al. - Twenty-eight-day double-blind safety study of an HFA-134a inhalation aerosol system in health subjects'. - J. Pharm. Pharmacol., 48, 596-600, 1996.
7. SOINE W.H., BLONDINO F.E. and BYRON P.R. - Chemical stability in pressurized inhalers formulated as solutions. - J. Biopharm. Sci., 3, 41-47, 1992.
8. PHILLIPS E.M. and BYRON P.R. - Surfactant promoted crystal growth of micronized methylprednisolone in trichlorofluoromethane. - Int. J. Pharm., 110, 9-19, 1994.
9. PHILLIPS E.M., BYRON P.R. and DALBY R.N. - Axial ratio measurements for early detection of crystal growth in suspension-type metered-dose inhalers. - Pharm. Res., 10, 454-456, 1993.
10. PHILLIPS E.M. and BYRON P.R. - Crystal growth of micronised methylprednisolone in trichlorofluoromethane. - Pharm. Res., 8, S-174, 1991.
11. HIGUCHI W.I. and LAU P.K. - Experimental method for studying growth rates of particles in aqueous media. - J. Pharm. Sci., 51, 1081-1084, 1962.
12. CARLESS J.E. and FOSTER A.A. - Accelerated crystal growth of sulfathiazole by temperature cycling. - J. Pharm. Pharmacol., 18, 697-708, 1966.
13. MEHTA S.C. et al. - Rate of crystal growth of sulfathiazol and methylprednisolone. - J. Pharm. Sci., 59, 638-644, 1970.
14. SIMONELLI A.P., MEHTA S.C. and HIGUCHI W.I. - Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone. - J. Pharm. Sci., 59, 633-637, 1970.
15. DALBY R.N., PHILLIPS E.M. and BYRON P.R. - Determination of drug solubility in aerosol propellants. - Pharm. Res., 8, 9, 1206-1209, 1991.
16. MILLER N.C. - The effects of water in inhalation suspension aerosol formulations. - In: Respiratory Drug Delivery, P.R. Byron Ed., CRC Press, Boca Raton, 1990, pp. 249-257.
17. KIM Y., ATWELL S.H. and BELL R.G. - Determination of water in pressurized pharmaceutical metered-dose aerosol products. - Drug Dev. Ind. Pharm., 18, 20, 2185-2195, 1992.
18. WADE A. and WELLER P.J. - Hydroxypropyl methylcellulose. - In: Handbook of Pharmaceutical Excipients, A. Wade and P.J. Weller Eds., American Pharmaceutical Association, Washington, 1994, pp. 229-232.
19. SWEET D. V. - Registry of Toxic Effects of Chemical Substances. - US Department of Health, Cincinnati, 1987.