Production of amarogentin in root cultures of Swertia chirata

Planta Medica

Volumn 66, Issue 5, 2000, Pages 452-457

  Keil, Michael ^a   Härtle, Birgit ^a   Guillaume, Anna ^a   Psiorz, Manfred ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Agrobacterium rhizogenes; Amarogentin; Gentianaceae; Root cultures; Swertia chirata

Indexed keywords

AMAROGENTIN; CHITOSAN; SALICYLIC ACID;

ARTICLE; DRUG SYNTHESIS; FERMENTATION; HERBAL MEDICINE; NONHUMAN; PHYTOCHEMISTRY; PLANT GROWTH; PLANT ROOT;

BIOREACTORS; CHITIN; CHITOSAN; CULTURE MEDIA; CULTURE TECHNIQUES; GLUCOSIDES; IRIDOIDS; PLANT ROOTS; PLANTS, MEDICINAL; PYRANS; RHIZOBIUM;

EID: 0034048002     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-8579     Document Type: Article

References (21)

1. 1 Jain SK. Chirayata. In: Keskar BV, Thacker MS, editors. Medicinal Plants. New Delhi: National Book Trust, 1968: 135-6
2. 2 Inouye H, Nakamura Y. Über die Monoterpenglucoside und verwandte Naturstoffe - XIV. Die Struktur der beiden stark bitter schmeckenden Glucoside Amarogentin und Amaroswerin aus Swertia japonica. Tetrahedron 1971; 27: 1951-66
3. 3 Takino Y, Koshioka M, Kawaguchi M, Miyahara T, Tanizawa H, Ishii Y, et al. Quantitative determination of bitter components in Swertiae herba. Planta Medica 1980; 38: 351-5
4. 4 Kreis W. Arzneistoffe aus pflanzlichen Zell-und Gewebekulturen: Möglichkeiten und Grenzen. Deutsche Apotheker Zeitung 1993; 15: 17-42
5. 5 Wysokinska H, Chmiel A. Transformed root cultures for biotechnology. Acta Biotechnology 1997; 17: 131-59
6. 6 Miura H. Swertia spp.: In vitro culture, regeneration, and the production of secondary metabolites. In: Bajai YPS, editor. Biotechnology in Agriculture and Forestry: Medicinal and Aromatic Plants Vol. III. Heidelberg: Springer, 1991: 451-63
7. 7 Ishimaru K, Shimomura K. Genetic transformation in Swertia japonica. In: Bajai YPS, editor. Biotechnology in Agriculture and Forestry: Plant Protoplasts and Genetic Engineering Vol. VII. Heidelberg: Springer, 1996: 308-17
8. 8 Franklin CI, Dixon RA. Initiation and maintenance of callus and cell suspension cultures. In: Dixon RA, Gonzales RA, editors. Plant Cell Culture - A Practical Approach. Oxford: IRL Press, 1994: 1-25
9. 9 Koblitz H, Hagen I. Vergleichende Untersuchungen über das Wachstum isolierter Karottengewebe auf halbsynthetischen Substraten und auf einem neuen vollsynthetischen Medium. Flora (Jena) 1962; 162: 447-57
10. 10 EMBO Course. The use of Ti plasmid as cloning vector for genetic engineering in plants. 4-23 August, 1982: 109.
11. 11 Porter JR. Host range and implications of plant infection by Agrobacterium rhizogenes. Critical Reviews in Plant Science 1991; 10: 387-421
12. 12 Jaziri M, Homès J, Shimomura K. An unusual root tip formation in hairy root culture of Hyoscyamus muticus. Plant Cell Reports 1994; 13: 349-52
13. 13 Merkli A, Christen P, Kapetanidis I. Production of diosgenin by hairy root cultures of Trigonella foenum-graecum L. Plant Cell Reports 1997; 16: 632-6
14. 14 Blechert S, Brodschelm W, Hölder S, Kammerer L, Kutchan TM, Müller MJ, et al. The octadecanoid pathway: signal molecules for the regulation of secondary pathways. Proceedings of the National Academy of Sciences USA 1995; 92: 4099-105
15. 15 Zabetakis I, Edwards R, O'Hagan D. Elcitation of tropane alkaloid biosynthesis in transformed root cultures of Datura stramonium. Phytochemistry 1999; 50: 53-6
16. 16 Godoy-Hernandez G, Loyola-Vargas VM. Effect of acetylsalicylic acid on secondary metabolism of Catharantus roseus tumor suspension cultures. Plant Cell Reports 1997; 16: 287-90
17. th Annual Congress of the Society of Medicinal Plant Research. Prague: Society of Medicinal Plant Research, 1996:: 74-5
18. 18 Kauss H, Jeblick W, Domard A. The degrees of polymerization and N-acetylation of chitosan determine its ability to elicit callose formation in suspension cells and protoplasts of Catharantus roseus. Planta 1989; 178: 385-92
19. 19 Dörnenburg H. Einsatz von Chitosan bei der Kultivierung pflanzlicher Zellkulturen: Ausbeutesteigerung, Permeabilisierung und Immobilisierung. BIOforum 1996; 3: 52-62
20. 20 Boitel-Conti M, Gontier E, Laberche J-C. Inducer effect of tween 20 permeabilization treatment used for release of stored tropane alkaloids in Datura innoxia Mill. hairy root cultures. Plant Cell Reports 1996; 16: 241-4
21. 21 Wilson PDG. The pilot-scale cultivation of transformed roots. In: Doran PM, editors. Hairy Roots: Culture and Applications. Amsterdam: Harwood Academic Publishers, 1997: 179-90