Down-regulation by drugs of the increased signal transduction in cancer cells

Advances in Enzyme Regulation

Volumn 40, Issue 1, 2000, Pages 19-34

  Weber, George ^a   Shen, Fei ^a   Prajda, Noemi ^b   Abonyi, Margit ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Meditest Ltd   (Hungary)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GENISTEIN; INOSITOL TRISPHOSPHATE; PHOSPHATIDYLINOSITOL; QUERCETIN; RIBAVIRIN; TAMOXIFEN; TIAZOFURIN;

ANIMAL; CANCER CELL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN TISSUE; LIVER; LIVER TUMOR; METABOLISM; PATHOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034047771     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(99)00039-4     Document Type: Conference Paper

References (27)

1. G. WEBER, Enzymology of cancer cells, New Engl. J. Med. 296, 486-551 (1977).
2. G. WEBER, Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes Memorial Lecture, Cancer Res. 43, 3466-3492 (1983).
3. G. WEBER, F. SHEN, N. PRAJDA, Y. A. YEH, H. YANG, M. HERENYIOVA and K. Y. LOOK, Increased signal transduction activity and down-regulation in human cancer cells, Anticancer Res. 16, 3271-3282 (1996).
4. G. WEBER, N. PRAJDA, M. ABONYI, K. Y. LOOK and G. TRICOT, Tiazofurin: molecular and clinical action, Anticancer Res. 16, 3313-3322 (1996).
5. G. TRICOT and G. WEBER, Biochemically targeted therapy of refractory leukemia and myeloid blast crisis of chronic granulocytic leukemia with tiazofurin, a selective blocker of inosine 5′-phosphate dehydrogenase activity, Anticancer Res. 16, 3341-3348 (1996).
6. G. WEBER, F. SHEN, H. YANG, N. PRAJDA and W. LI, Amplification of signal transduction capacity and down-regulation by drugs, Advan. Enzyme Regul. 39, 51-66 (1999).
7. H. YANG, F. SHEN and G. WEBER, Amplified increase in signal transduction activity in cancer cells, Anticancer Res. 19, Accepted (1999).
8. W. LI and G. WEBER, Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells, Oncol. Res. 10, 117-122 (1998).
9. W. LI, F. SHEN and G. WEBER, Ribavirin and quercetin synergistically down-regulate signal transduction and are cytotoxic in human ovarian carcinoma cells, Oncol. Res. 11, 243-247 (1999).
10. F. SHEN and G. WEBER, Synergistic action of quercetin and genistein in human ovarian carcinoma cells, Oncol. Res. 9, 597-602 (1997).
11. F. SHEN and G. WEBER, Tamoxifen down-regulates signal transduction and is synergistic with tiazofurin in human breast carcinoma MDA-MB-435 cells, Oncol. Res. 10, 325-331 (1998).
12. F. SHEN, X. XUE and G. WEBER, Tamoxifen and genistein synergistically down-regulate signal transduction and proliferation in estrogen receptor-negative human breast carcinoma MDA-MB-435 cells, Anticancer Res. 19, 1657-1662 (1999).
13. K. Y. LOOK, G. P. SUTTON, Y. NATSUMEDA, J. N. EBLE, F. B. STEHMAN, C. E. EHRLICH, E. OLAH, N. PRAJDA, P. BOSZE, S. ECKHARDT and G. WEBER, Inhibition by tiazofurin of inosine 5′-phosphate dehydrogenase (IMP DH) activity in extracts of ovarian carcinomas, Gynecol. Oncol. 47, 66-70 (1992).
14. K. Y. LOOK, D. H. MOORE, G. P. SUTTON, N. PRAJDA, M. ABONYI and G. WEBER, Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma, Anticancer Res. 17, 2353-2356 (1997).
15. T-C. CHOU and P. TALALAY, Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors, Advan. Enzyme Regul. 22, 27-55 (1984).
16. J. L. Webb. Enzyme and Metabolic Inhibitors. Academic Press, New York. vol. 1. pp. 507-510 (1963).
17. M. T. RIZZO and G. WEBER, 1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy, Cancer Res. 54, 2611-2614 (1994).
18. R. L. SINGHAL, N. PRAJDA, Y. A. YEH and G. WEBER, 1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation-and malignancy-linked signal transduction enzyme, Cancer Res. 54, 5574-5578 (1994).
19. R. L. SINGHAL, Y. A. YEH, K. Y. LOOK, G. W. SLEDGE JR and G. WEBER, Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells, Life Sci. 55, 1487-1492 (1994).
20. D. G. WRIGHT, M. S. BOOSALIS, L. J. OSHRY and K. WARASKA, Tiazofurin effects on IMP dehydrogenase activity and expression in the leukemic cells of patients with CML blast crisis, Anticancer Res. 16, 3349-3354 (1996).
21. G. WEBER, M. NAGAI, Y. NATSUMEDA, J. N. EBLE, H. N. JAYARAM, E. PAULIK, W. ZHEN, R. HOFFMAN and G. TRICOT, Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient, Cancer Commun. 3, 61-66 (1991).
22. E. OLAH, Y. NATSUMEDA, T. IKEGAMI, Z. KOTE, M. HORANI, J. SZELENYI, E. PAULIK, T. KREMMER, S. R. HOLLAN, J. SUGAR and G. WEBER, Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells, Proc. Natl. Acad. Sci., USA 85, 6533-6537 (1988).
23. E. OLAH, Z. KOTE, Y. NATSUMEDA, Y. YAMAJI, G. JARAI, E. LAPIS, I. FINANCSEK and G. WEBER, Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells, Cancer Biochem. Biophys. 11, 107-117 (1990).
24. E. OLAH, B. CSOKAY, N. PRAJDA, Z. KOTE-JARAI, Y. A. YEH and G. WEBER, Molecular mechanisms in the antiproliferative action of taxol and tiazofurin, Anticancer Res. 16, 2469-2478 (1996).
25. B. CSOKAY, N. PRAJDA, G. WEBER and E. OLAH, Molecular mechanisms in the antiproliferative action of quercetin, Life Sci. 60, 2157-2163 (1997).
26. A. CONSTANTINOU, K. KIGUCHI and E. HUBERMAN, Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein, Cancer Res. 50(9), 2618-2624 (1990).
27. F. SHEN, M. HERENYIOVA and G. WEBER, Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells, Life Sci. 64, 1869-1876 (1999).