Comparison of effects of CH50 on macrophage activation and its anti- tumor activity with those of lipopolysaccharides

Acta Pharmacologica Sinica

Volumn 21, Issue 6, 2000, Pages 567-570

  Zhang, Gui Mei ^a   Feng, Zuo Hua ^a   Li, Dong ^a   Zhang, Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Fibronectins; Interferon type II; experimental melanoma; macrophage activation; Lipopolysaccharides; Recombinant fusion proteins

Indexed keywords

CH 50; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; DRUG EFFECT; MACROPHAGE ACTIVATION; MELANOMA; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; FIBRONECTINS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MELANOMA, EXPERIMENTAL; MICE; NEOPLASM TRANSPLANTATION; NITRIC OXIDE; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

EID: 0034047227     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Feng ZH, Zhang GM, Li D, Zhang H. Construction of expressing plasmids of recombinant FN polypeptides with bifunctional- domain and the characterization of the products expressed in E. coli. J Tongji Med Univ 1996; 16: 70-4.
2. Fan Q, Feng ZH, Zhang GM, Zhang H, Cao HQ. Effect of recombinant human fibronectin polypeptide CH50 on growth and metastasis of melanoma. Acta Pharmacol Sin 1999; 20: 175-8.
3. Feng ZH, Zhang GM, Zhang H, Fan Q. Augmentation of recombinant fibronectin polypeptide CH50 on the antitumor function of macrophages. Chin J Immunol 1998; 14: 268-9.
4. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning, a laboratory manual. 2nd ed. New York; Cold Spring Harbor Laboratory Press; 1989. p16.32-16.39.
5. Kohn FR, Klingemann HG. Regulation of fibronectin receptor (alpha 5 beta 1) mRNA expression in human monocytes and monocyte-derived macrophages by activation/differentiation signals. Exp Hematol 1991; 19: 653-8.
6. Caroline GL, Lee L, Demarquoy J, Jackson MJ, O' Brien WE. Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol 1994; 152; 5758-67.
7. Chang ZL, Beezhold DH, Personius CD, Shen ZL. Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes. J Leukocyte Biol 1993; 53: 79-85.
8. Zhang GM, Feng ZH, Zhang H, Li D, Fan Q. Comparative study on the inhibitory effect of recombinant EN polypeptide CH50 and CH56 on the metastasis of melanoma cells. J Tongji Med Univ 1997; 17: 129-31.
9. Saiki I, Matsumoto Y, Murata J, Makabe T, Yoneda J, Okuyama H, et al. Recombinant fusion polypeptide with cell and Heparin-binding domains of fibronectin inhibts liver metastasis of L5178Y-ML25 lymphoma cells. Jpn J Cancer Res 1991; 82: 1120-9.