Marburg and Ebola virus infections in laboratory non-human primates: A literature review

Comparative Medicine

Volumn 50, Issue 2, 2000, Pages 108-123

  Schou, Søren ^a   Hansen, Axel Kornerup ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EBOLA VIRUS; EPIDEMIC; INFECTION RISK; MARBURG VIRUS; MONKEY; NONHUMAN; PRIMATE; REVIEW; VIROLOGY; VIRUS INFECTION; VIRUS TRANSMISSION;

ANIMALS; ANIMALS, LABORATORY; DISEASE OUTBREAKS; DISEASE RESERVOIRS; DISEASE TRANSMISSION, HORIZONTAL; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HISTORY, 20TH CENTURY; HUMANS; MARBURG VIRUS DISEASE; MARBURGVIRUS; PRIMATE DISEASES; PRIMATES; QUARANTINE; RISK ASSESSMENT; SURVIVAL RATE; ZOONOSES;

EID: 0034047086     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (257)

1. Schou, S., P. Holmstrup, and K. S. Kornman. 1993. Non-human primates used in studies of periodontal disease pathogenesis: A review of the literature. J. Periodontol. 64:497-508.
2. Kalter, S. S. and R. L. Heberling. 1975. Biohazards and simian viruses. Bibl. Haematol. 40:759-769.
3. Kalter, S. S. and R. L. Heberling. 1978. Health hazards associated with newly imported primates and how to avoid them, p. 5-21. In D. J. Chivers, E. H. R. Ford (eds.), Recent Advances in Primatology. Academic Press, London, Great Britain.
4. Pattyn, S. R. 1978. Ebola virus haemorrhagic fever. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands.
5. Howard, C. R. 1984. Viral haemorrhagic fevers: Properties and prospects for treatment and prevention. Antiviral Res. 4:169-186.
6. Swanepoel, R. 1987. Viral haemorrhagic fevers in South Africa: History and national strategy. S. Afr. J. Med. Sci. 83:80-88.
7. Kalter, S. S. and R. L. Heberling. 1990. Primate viral diseases in perspective. J. Med. Primatol. 19:519-535.
8. Peters, C. J., E. D. Johnson, and K. T. McKee. 1991. Filoviruses and management of viral hemorrhagic fevers, p. 699-712. In R. B. Belshe (ed.), Textbook of human virology. Mosby Year-Book, St. Louis, MO.
9. Andrei, G. and E. De Clercq. 1993. Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 22:45-75.
10. Peters, C. J., P. B. Jahrling, and A. S. Khan. 1996. Patients infected with high hazard viruses: Scientific basis for infection control. Arch. Virol. Suppl. 11:141-168.
11. Le Guenno, B. 1997. Haemorrhagic fevers and ecological perturbations. Arch. Virol. Suppl. 13:191-199.
12. Klenk, H.-D. 1999. Marburg and Ebola viruses. Curr. Top. Microbiol. Immunol 235:1-225.
13. Hennessen, W., O. Bonin, and R. Mauler. 1968. Zur epidemiologie der erkrankung von menschen durch affen. Dtsch. Med. Wochenschr. 93:582-589.
14. Martini, G. A., H. G. Knauff, H. A. Schmidt,et al. 1968. Über eine bisher unbekannte, von affen eingeschleppte infektionskrankheit: Marburg-virus-krankheit. Dtsch. Med. Wochenschr. 93:559-571.
15. Siegert, R., H.-L. Shu, and W. Slenczka. 1968. Nachweis des "Marburg-virus" beim patienten. Dtsch. Med. Wochenschr. 93:616-619.
16. Stille, W., E. Böhle, E. Helm, et al. 1968. Über eine durch Cercopithecus aethiops übertragene infektionskrankheit. Dtsch. Med. Wochenschr. 93:572-582.
17. Martini, G. A., and R. Siegert. 1971. Marburg Virus Disease. Springer Verlag, Berlin, Germany.
18. Gear, J. S. S., G. A. Cassel, A. J. Gear, et al. 1975. Outbreak of Marburg virus disease in Johannesburg. Br. Med. J. 4:489-493.
19. Emond, R. T. D., B. Evans, E. T. W. Bowen, et al. 1977. A case of Ebola virus infection. Br. Med. J. 2:541-544.
20. World Health Organization. 1978. Ebola haemorrhagic fever in Sudan, 1976. Bull. WHO 56:247-270.
21. World Health Organization. 1978. Ebola haemorrhagic fever in Zaire, 1976. Bull. WHO 56:271-293.
22. World Health Organization. 1979. Viral haemorrhagic fever surveillance. Weekly Epidemiol. Rec. 54:342-343.
23. Williams, E. H. 1979. 44 contacts of Ebola virus infection -Salisbury. Public Health 93:67-75.
24. Heymann, D. L., J. S. Weisfeld, P. A. Webb, et al. 1980. Ebola hemorrhagic fever: Tandala, Zaire, 1977-1978. J. Infect. Dis. 142:372-376.
25. World Health Organization. 1980. Viral haemorrhagic fever surveillance. Weekly Epidemiol. Rec. 55:59.
26. Smith, D. H., B. K. Johnson, M. Isaacson, et al. 1982. Marburg-virus disease in Kenya. Lancet 1:(8276):816-820.
27. Baron, R. C., J. B. McCormick, and O. A. Zubeir. 1983. Ebola virus disease in southern Sudan: Hospital dissemination and intrafamilial spread. Bull. WHO 61:997-1003.
28. Teepe, R. G. C., B. K. Johnson, D. Ocheng, et al. 1983. A probable case of Ebola virus haemorrhagic fever in Kenya. East Afr. Med. J. 60:718-722.
29. Centers for Disease Control and Prevention. 1989. Ebola virus infection in imported primates - Virginia, 1989. MMWR 38:831-832, 837-838.
30. Centers for Disease Control and Prevention. 1990. Update: Ebola-related filovirus infection in nonhuman primates and interim guidelines for handling nonhuman primates during transit and quarantine. MMWR 39:22-24, 29-30.
31. Centers for Disease Control and Prevention. 1990. Update: Filovirus infection in animal handlers. MMWR 39:221.
32. Jahrling, P. B., T. W. Geisbert, D. W. Dalgard, et al. 1990. Preliminary report: Isolation of Ebola virus from monkeys imported to USA. Lancet 335:502-505.
33. Dalgard, D. W., R. J. Hardy, S. L. Pearson, et al. 1992. Combined simian hemorrhagic fever and Ebola virus infection in cynomolgus monkeys. Lab. Anim. Sci. 42:152-157.
34. World Health Organization. 1992. Viral haemorrhagic fever in imported monkeys. Weekly Epidemiol. Rec. 67:142-143.
35. Centers for Disease Control and Prevention. 1995. Outbreak of Ebola viral hemorrhagic fever - Zaire, 1995. MMWR 44:381-382.
36. Centers for Disease Control and Prevention. 1995. Update: Outbreak of Ebola viral hemorrhagic fever - Zaire, 1995. MMWR 44:468-469, 475.
37. Le Guenno, B., P. Formentry, M. Wyers, et al. 1995. Isolation and partial characterisation of a new strain of Ebola virus. Lancet 345:1271-1274.
38. Muyembe, T., and M. Kipasa. 1995. Ebola haemorrhagic fever in Kikwit, Zaire. Lancet 345:1448.
39. World Health Organization. 1995. Ebola haemorrhagic fever. Weekly Epidemiol. Rec. 70:149-150.
40. World Health Organization. 1995. Ebola haemorrhagic fever. Weekly Epidemiol. Rec. 70:241-242.
41. Centers for Disease Control and Prevention. 1996. Ebola-Reston virus infection among quarantined nonhuman primates -Texas, 1996. MMWR 45:314-316.
42. Johnson, E. D., B. K. Johnson, D. Silverstein, et al. 1996. Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya. Arch. Virol. Suppl. 11:101-114.
43. World Health Organization. 1996. Outbreak of Ebola haemorrhagic fever in Gabon officially declared over. Weekly Epidemiol. Rec. 71:125-126.
44. World Health Organization. 1996. Ebola haemorrhagic fever. Weekly Epidemiol. Rec. 71:320.
45. World Health Organization. 1996. Ebola haemorrhagic fever. Weekly Epidemiol. Rec. 71:359.
46. Amblard, J., P. Obiang, S. Edzang, et al. 1997. Identification of the Ebola virus in Gabon in 1994. Lancet 349:181-182.
47. Georges-Courbot, M. C., C. Y. Lu, J. Lansoud - Soukate, et al. 1997. Isolation and partial molecular characterisation of a strain of Ebola virus during a recent epidemic of viral haemorrhagic fever in Gabon. Lancet 349:181.
48. Georges-Courbot, M. C., A. Sanchez, C. Y. Lu, et al. 1997. Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon. Emerg. Infect. Dis. 3:59-62.
49. World Health Organization. 1997. Ebola haemorrhagic fever. A summary of the outbreak in Gabon. Weekly Epidemiol. Rec. 72:7-8.
50. Formenty, P., C. Hatz, B. Le Guenno, et al. 1999. Human infection due to Ebola virus, subtype Côte d'Ivoire: Clinical and biologic presentation. J. Infect. Dis. Suppl. 179:48-53.
51. Formenty, P., C. Boesch, M. Wyers, et al. 1999. Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'Ivoire. J. Infect. Dis. Suppl. 179:120-126.
52. Georges, A.-J., E. M. Leroy, A. A. Renaut, et al. 1999. Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: Epidemiologic and health control issues. J. Infect. Dis. Suppl. 179:65-75.
53. Guimard, Y., M. A. Bwaka, R. Colebunders, et al. 1999. Organization of patient care during the Ebola hemorrhagic fever epidemic in Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:268-273.
54. Khan, A. S., F. K. Tshioko, D. L. Heymann, et al. 1999. The reemergence of Ebola hemorrhagic fever, Democratic Rebublic of the Congo, 1995. J. Infect. Dis. Suppl. 179:76-86.
55. Rollin, P. E., R. J. Williams, D. S. Bressler, et al. 1999. Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States. J. Infect. Dis. Suppl. 179:108-114.
56. Clayton, A. J. 1979. Lassa fever, Marburg and Ebola virus diseases and other exotic diseases: Is there a risk to Canada? Can. Med. Assoc. J. 120:146-155.
57. Samaranayake, L. P., J. S. M. Peiris, and C. Scully. 1996. Ebola virus infection: An overview. Br. Dent. J. 180:264-266.
58. Feldmann, H., H.-D. Klenk, and A. Sanchez. 1993. Molecular biology and evolution of filoviruses. Arch. Virol. Suppl. 7:81-100.
59. Peters, C. J., E. D. Johnson, P. B. Jahrling, et al. 1993. Filoviruses, p. 159-175. In S. S. Morse (ed.), Emerging Viruses. Oxford University Press, New York, NY.
60. Peters, C. J., A. Sanchez, H. Feldmann, et al. 1994. Filoviruses as emerging pathogens. Semin. Virol. 5:147-154.
61. Feldmann, H., and H.-D. Klenk. 1996. Marburg and Ebola viruses. Adv. Virus Res. 47:1-52.
62. Feldmann, H., W. Slenczka, and H.-D. Klenk. 1996. Emerging and reemerging of filoviruses. Arch. Virol. Suppl. 11:77-100.
63. Peters, C. J., A. Sanchez, P. E. Rollin, et al. 1996. Filoviridae: Marburg and Ebola viruses, p. 1161-1176. In B. N. Fields, D. M. Knipe, and P. M. Howley (eds.), Fields virology. Lippincott-Raven Publishers, Philadelphia, PA.
64. Tukei, P. M. 1996. Threat of Marburg and Ebola viral haemorrhagic fevers in Africa. East Afr. Med. J. 73:27-31.
65. Takada, A., and Y. Kawaoka. 1998. Pathogenesis of Ebola virus infection: Recent insights. Trends Microbiol. 6:258-259.
66. Beer, B., R. Kurth, and A. Bukreyev. 1999. Characteristics of filoviridae: Marburg and Ebola viruses. Naturwissenschaften 86:8-17.
67. Smith, C. E. G., D. I. H. Simpson, E. T. W. Bowen, et al. 1967. Fatal human disease from vervet monkeys. Lancet 2:1119-1121.
68. Conrad, J. L., M. Isaacson, E. B. Smith, et al. 1978. Epidemiologic investigation of Marburg virus disease, southern Africa. Am. J. Trop. Med. Hyg. 27:1210-1215.
69. Cox, N. J., J. B. McCormick, K. M. Johnson, et al. 1983. Evidence for two subtypes of Ebola virus based on oligonucleotide mapping of RNA. J. Infect. Dis. 147:272-275.
70. World Health Organization. 1989. Ebola virus update. Weekly Epidemiol. Rec. 64:389-390.
71. Hayes, C. G., J. P. Burans, T. G. Ksiazek, et al. 1992. Outbreak of fatal illness among captive macaques in the Philippines caused by an Ebola-related filovirus. Am. J. Trop. Med. Hyg. 46:664-671.
72. Centers for Disease Control and Prevention. 1990. Update: Evidence of filovirus infection in an animal caretaker in a research/service facility. MMWR 39:296-297.
73. Centers for Disease Control and Prevention. 1990. Update: Filovirus infections associated with contact with nonhuman primates or their tissues. MMWR 39:404-405.
74. Centers for Disease Control and Prevention. 1990. Update: Filovirus infections among persons with occupational exposure to nonhuman primates. MMWR 39:266-267, 273.
75. Miranda, M. E. G., M. E. White, M. M. Dayrit, et al. 1991. Seroepidemiological study of filovirus related to Ebola in the Philippines. Lancet 373:425-426.
76. Miranda, M. E., T. G. Ksiazek, T. J. Retuya, et al. 1999. Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. J. Infect. Dis. Suppl. 179:115-119.
77. Anderson, G. C. 1990. US shuts down monkey trade. Nature 344:369.
78. Kissling, R. E., R. Q. Robinson, F. A. Murphy, et al. 1968. Agent of disease contracted from green monkeys. Science 160:888-890.
79. Bowen, E. T. W., D. I. H. Simpson, W. F. Bright, et al. 1969. Vervet monkey disease: Studies on some physical and chemical properties of the causative agent. Br. J. Exp. Pathol. 50:400-407.
80. 60Co irradiation. J. Infect. Dis. 143:291.
81. Elliott, L. H., J. B. McCormick, and K. M. Johnson. 1982. Inactivation of Lassa, Marburg, and Ebola viruses by gamma irradiation. J. Clin. Microbiol. 16:704-708.
82. van der Groen, G., and L. H. Elliott. 1982. Use of betapropionolactone inactivated Ebola, Marburg and Lassa intracellular antigens in immunofluorescent antibody assay. Ann. Soc. Belg. Med. Trop. 62:49-54.
83. Mitchell, S. W. and J. B. McCormick. 1984. Physicochemical inactivation of Lassa, Ebola, and Marburg viruses and effect on clinical laboratory analyses. J. Clin. Microbiol. 20:486-489.
84. Centers for Disease Control and Prevention. 1988. Management of patients with suspected viral hemorrhagic fever. MMWR 37(No. S-3):1-15.
85. Takada, A., C. Robison, H. Goto, et al. 1997. A system for functional analysis of Ebola virus glycoprotein. Proc. Natl. Acad. Sci. USA 94:14764-14769.
86. Wool-Lewis, R. J., and P. Bates. 1998. Characterization of Ebola virus entry by using pseudotyped viruses: Identification of receptor-deficient cell lines. J. Virol. 72:3155-3160.
87. Yang, Z.-Y., R. Delgado, L. Xu, et al. 1998. Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins. Science 279:1034-1037.
88. Siegert, R., H.-L. Shu, W. Slenczka, et al. 1967. Zur ätiologie einer unbekannten, von affen ausgegangenen menschlichen infektionskrankheit. Dtsch. Med. Wochenschr. 92:2341-2343.
89. Zlotnik, I., D. I. H. Simpson, and D. M. R. Howard. 1968. Structure of the vervet-monkey-disease agent. Lancet 2A:26-28.
90. Peters, D., and G. Müller. 1969. The Marburg agent and structures associated with leptospira. Lancet 1:923-925.
91. Murphy, F. A., D. I. H. Simpson, S. G. Whitfield, et al. 1971. Marburg virus infection in monkeys. Ultrastructural studies. Lab. Invest. 24:279-291.
92. Pattyn, S., G. van der Groen, W. Jacob, et al. 1977. Isolation of Marburg-like virus from a case of hæmorrhagic fever in Zaire. Lancet 1:(8011):573-574.
93. Ellis, D. S., D. I. H. Simpson, D. P. Francis, et al. 1978. Ultrastructure of Ebola virus particles in human liver. J. Clin. Pathol. 31:201-208.
94. Ellis, D. S., E. T. W. Bowen, D. I. H. Simpson, et al. 1978. Ebola virus: A comparison, at ultrastructural level, of the behaviour of the Sudan and Zaire strains in monkeys. Br. J. Exp. Pathol. 59:584-593.
95. Regnery, R. L., K. M. Johnson, and M. P. Kiley. 1980. Virion nucleic acid of Ebola virus. J. Virol. 36:465-469.
96. Kiley, M. P., E. T. W. Bowen, G. A. Eddy, et al. 1982. Filoviridae: A taxonomic home for Marburg and Ebola viruses? Intervirology 18:24-32.
97. International Committee on Taxonomy of Virus (ICTV). The Paramyxovirus Study Group. 1991. The order Mononegavirales. Arch. Virol. 117:137-140.
98. Feldmann, H., E. Mühlberger, A. Randolf, et al. 1992. Marburg virus, a filovirus: Messenger RNAs, gene order, and regulatory elements of the replication cycle. Virus Res. 24:1-19.
99. Bukreyev, A. A., V. E. Volchkov, V. M. Blinov, et al. 1993. The GP-protein of Marburg virus contains the region similar to the "immunosuppressive domain" of oncogenic retrovirus P15E proteins. FEBS Lett. 323:183-187.
100. Bukreyev, A. A., V. E. Volchkov, V. M. Blinov, et al. 1995. The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: A comparison with the Musoke (1980) strain. Arch. Virol. 140:1589-1600.
101. Bowen, E. T. W., G. Lloyd, W. J. Harris, et al. 1977. Viral haemorrhagic fever in southern Sudan and northern Zaire. Lancet. 1:(8011):571-573.
102. Johnson, K. M., J. V. Lange, P. A. Webb, et al. 1977. Isolation and partial characterisation of a new virus causing acute hæmorrhagic fever in Zaire. Lancet 1:(8011):569-571.
103. Ellis, D. S., S. Stamford, G. Lloyd, et al. 1979. Ebola and Marburg viruses: I. Some ultrastructural differences between strains when grown in Vero cells. J. Med. Virol. 4:201-211.
104. Ellis, D. S., S. Stamford, D. G. Tovey, et al. 1979. Ebola and Marburg viruses: II. Their development within Vero cells and the extra-cellular formation of branched and torus forms. J. Med. Virol. 4:213-225.
105. Schnittler, H.-J., F. Mahner, D. Drenckhahn, et al. 1993. Replication of Marburg virus in human endothelial cells. A possible mechanism for the development of viral hemorrhagic disease. J. Clin. Invest. 91:1301-1309.
106. Geisbert, T. W., and P. B. Jahrling. 1995. Differentiation of filoviruses by electron microscopy. Virus Res. 39:129-150.
107. Kiley, M. P., N. J. Cox, L. H. Elliot, et al. 1988. Physicochemical properties of Marburg virus: Evidence for three distinct virus strains and their relationship to Ebola virus. J. Gen. Virol. 69:1957-1967.
108. Feldmann, H., S. T. Nichol, H.-D. Klenk, et al. 1994. Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein. Virology 199:469-473.
109. Sanchez, A., S. G. Trappier, U. Ströher, et al. 1998. Variation in the glycoprotein and VP35 genes of Marburg virus strains. Virology 240:138-146.
110. Sanchez, A., S. G. Trappier, B. W. J. Mahy et al. 1996. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc. Natl. Acad. Sci. USA 93:3602-3607.
111. Bowen, E. T. W., G. S. Platt, G. Lloyd, et al. 1980. A comparative study of strains of Ebola virus isolated from southern Sudan and northern Zaire in 1976. J. Med. Virol. 6:129-138.
112. Buchmeier, M. J., R. U. DeFries, J. B. McCormick, et al. 1983. Comparative analysis of the structural polypeptides of Ebola viruses from Sudan and Zaire. J. Infect. Dis. 147:276-281.
113. Richman, D. D., P. H. Cleveland, J. B. McCormick, et al. 1983. Antigenic analysis of strains of Ebola virus: Identification of two Ebola virus serotypes. J. Infect. Dis. 147:268-271.
114. Elliott, L. H., M. P. Kiley, and J. B. McCormick. 1985. Descriptive analysis of Ebola virus proteins. Virology 147:169-176.
115. Kiley, M. P., J. Wilusz, J. B. McCormick, et al. 1986. Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. Virology 149:251-254.
116. Sanchez, A., and M. P. Kiley. 1987. Identification and analysis of Ebola virus messenger RNA. Virology 157:414-420.
117. Sanchez, A., M. P. Kiley, B. P. Holloway, et al. 1989. The nucleoprotein gene of Ebola virus: Cloning, sequencing, and in vitro expression. Virology 170:81-91.
118. Geisbert, T. W. and P. B. Jahrling. 1990. Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic. J. Clin. Pathol. 43:813-816.
119. Fisher-Hoch, S. P., T. L. Brammer, S. G. Trappier, et al. 1992. Pathogenic potential of filoviruses: Role of geographic origin of primate host and virus strain. J. Infect. Dis. 166:753-763.
120. Geisbert, T. W., P. B. Jahrling, M. A. Hanes, et al. 1992. Association of Ebola-related Reston virus particles and antigen with tissue lesions of monkeys imported to the United States. J. Comp. Pathol. 106:137-152.
121. Geyer, H., C. Will, H. Feldmann, et al. 1992. Carbohydrate structure of Marburg virus glycoprotein. Glycobiology 2:299-312.
122. Mühlberger, E., A. Sanchez, A. Randolf, et al. 1992. The nucleotide sequence of the L gene of Marburg virus, a filovirus: Homologies with paramyxoviruses and rhabdoviruses. Virology 187:534-547.
123. Sanchez, A., M. P. Kiley, H. - D. Klenk, et al. 1992. Sequence analysis of the Marburg virus nucleoprotein gene: Comparison to Ebola virus and other non-segmented negative-strand RNA viruses. J. Gen. Virol. 73:347-357.
124. Bukreyev, A. A., V. E. Volchkov, V. M. Blinov, et al. 1993. The VP35 and VP40 proteins of filoviruses. Homology between Marburg and Ebola viruses. FEBS Lett. 322:41-46.
125. Sanchez, A., M. P. Kiley, B. P. Holloway, et al. 1993. Sequence analysis of the Ebola virus genome: Organization, genetic elements, and comparison with the genome of Marburg virus. Virus Res. 29:215-240.
126. Will, C., E. Mühlberger, D. Linder, et al. 1993. Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein. J. Virol. 67:1203-1210.
127. Bukreyev, A. A., E. F. Belanov, V. M. Blinov, et al. 1995. Complete nucleotide sequences of Marburg virus genes 5 and 6 encording VP30 and VP24 proteins. Biochem. Mol. Biol. Int. 35:605-613.
128. Volchkov, V. E., S. Becker, V. A. Volchkova, et al. 1995. GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases. Virology 214:421-430.
129. Jahrling, P. B., T. W. Geisbert, N. K. Jaax, et al. 1996. Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic. Arch. Virol. Suppl. 11:115-134.
130. Mühlberger, E., S. Trommer, C. Funke, et al. 1996. Termini of all mRNA species of Marburg virus: Sequence and secondary structure. Virology 223:376-380.
131. Davis, K. J., A. O. Anderson, T. W. Geisbert, et al. 1997. Pathology of experimental Ebola virus infection in African green monkeys. Involvement of fibroblastic reticular cells. Arch. Pathol. Lab. Med. 121:805-819.
132. Suzuki, Y., and T. Gojobori. 1997. The origin and evolution of Ebola and Marburg viruses. Mol. Biol. Evol. 14:800-806.
133. Volchkov, V., V. Volchkova, C. Eckel, et al. 1997. Emergence of subtype Zaire Ebola virus in Gabon. Virology 232:139-144.
134. Sanchez, A., Z.-Y. Yang, L. Xu, et al. 1998. Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J. Virol. 72:6442-6447.
135. Prehaud, C., E. Hellebrand, D. Coudrier, et al. 1998. Recombinant Ebola virus nucleoprotein and glycoprotein (Gabon 94 strain) provide new tools for the detection of human infections. J. Gen. Virol. 79:2565-2572.
136. Sanchez, A., T. G. Ksiazek, P. E. Rollin, et al. 1999. Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates. J. Infect. Dis. Suppl. 179:164-169.
137. Jahrling, P. B. 1995. Filoviruses and arenaviruses, p. 1068-1081. In P. R Murray. (ed.), Manual of clinical microbiology. American Society for Microbiology, Washington, DC.
138. Simpson, D. I. H., E. T. W. Bowen, and W. F. Bright. 1968. Vervet monkey disease: Experimental infection of monkeys with the causative agent, and antibody studies in wild-caught monkeys. Lab. Anim. 2:75-81.
139. Kalter, S. S., J. J. Ratner, and R. L. Heberling. 1969. Antibodies in primates to the Marburg virus. Proc. Soc. Exp. Biol. Med. 130:10-12.
140. Slenczka, W., G. Wolff, and R. Siegert. 1971. A critical study of monkey sera for the presence of antibody against the Marburg virus. Am. J. Epidemiol. 93:496-505.
141. van der Groen, G., and S. R. Pattyn. 1979. Measurement of antibodies to Ebola virus in human sera from N. W. - Zaire. Ann. Soc. Belg. Med. Trop. 59:87-92.
142. Wulff, H., and K. M. Johnson. 1979. Immunoglobulin M and G responses measured by immunofluorescence in patients with Lassa or Marburg virus infections. Bull. WHO 57:631-635.
143. Johnson, K. M., L. H. Elliott, and D. L. Heymann. 1981. Preparation of polyvalent viral immunofluorescent intracellular antigens and use in human serosurveys. J. Clin. Microbiol. 14:527-529.
144. Blackburn, N. K., L. Searle, and P. Taylor. 1982. Viral haemorrhagic fever antibodies in Zimbabwe schoolchildren. Trans. R. Soc. Trop. Med. Hyg. 76:803-805.
145. Johnson, B. K., L. G. Gitau, A. Gichogo, et al. 1982. Marburg, Ebola and Rift Valley fever virus antibodies in East African primates. Trans. R. Soc. Trop. Med. Hyg. 76:307-310.
146. Stansfield, S. K., C. L. Scribner, R. M. Kaminski, et al. 1982. Antibody to Ebola virus in guinea pigs: Tandala, Zaire. J. Infect. Dis. 146:483-486.
147. Bouree, P. and J.-F. Bergmann. 1983. Ebola virus infection in man: A serological and epidemiological survey in the Cameroons. Am. J. Trop. Med. Hyg. 32:1465-1466.
148. Johnson, B. K., D. Ocheng, L. G. Gitau, et al. 1983. Viral haemorrhagic fever surveillance in Kenya, 1980-1981. Trop. Geogr. Med. 35:43-47.
149. Johnson, B. K., D. Ocheng, A. Gichogo, et al. 1983. Antibodies against haemorrhagic fever viruses in Kenya populations. Trans. R. Soc. Trop. Med. Hyg. 77:731-733.
150. Truant, A. L., R. L. Regnery, and M. P. Kiley. 1983. Development of an immunofluorescence focus assay for Ebola virus. J. Clin. Microbiol. 18:416-419.
151. Johnson, B. K., C. Wambui, D. Ocheng, et al. 1986. Seasonal variation in antibodies against Ebola virus in Kenyan fever patients. Lancet 1:(8490):1160.
152. Tomori, O., A. Fabiyi, A. Sorungbe, et al. 1988. Viral hemorrhagic fever antibodies in Nigerian populations. Am. J. Trop. Med. Hyg. 38:407-410.
153. van der Waals, F. W., K. L. Pomeroy, J. Goudsmit, et al. 1986. Hemorrhagic fever virus infections in an isolated rainforest area of central Liberia. Limitations of the indirect immunofluorescence slide test for antibody screening in Africa. Trop. Geogr. Med. 38:209-214.
154. Woodruff, P. W. R., J. C. Morrill, J. P. Burans, et al. 1988. A study of viral and rickettsial exposure and causes of fever in Juba, southern Sudan. Trans. R. Soc. Trop. Med. Hyg. 82:761-766.
155. Gonzalez, J. P., R. Josse, E. D. Johnson, et al. 1989. Antibody prevalence against haemorrhagic fever viruses in randomized representative central African populations. Res. Virol. 140:319-331.
156. Mathiot, C. C., D. Fontenille, A. J. Georges, and P. Coulanges. 1989. Antibodies to haemorrhagic fever viruses in Madagascar populations. Trans. R. Soc. Trop. Med. Hyg. 83:407-409.
157. Rodhain, F., J. P. Gonzalez, E. Mercier, et al. 1989. Arbovirus infections and viral haemorrhagic fevers in Uganda: A serological survey in Karamoja district, 1984. Trans. R. Soc. Trop. Med. Hyg. 83:851-854.
158. Mathiot, C. C., V. M. Hervé, and A. J. Georges. 1990. Antibodies to haemorrhagic fever viruses and to selected arboviruses in monkeys from the Central African Republic. Trans. R. Soc. Trop. Med. Hyg. 84:732-733.
159. Becker, S., H. Feldmann, C. Will, et al. 1992. Evidence for occurrence of filovirus antibodies in humans and imported monkeys: Do subclinical filovirus infections occur worldwide? Med. Microbiol. Immunol. 181:43-55.
160. Fisher-Hoch, S. P., G. I. Perez-Oronoz, E. L. Jackson, et al. 1992. Filovirus clearance in non-human primates. Lancet 340:451-453.
161. Lecatsas, G., F. A. Neethling, W. A. De Klerk, et al. 1992. Filovirus seropositivity in prospective organ donor baboons. Transplant. Proc. 24:617-618.
162. Elliott, L. H., S. P. Bauer, G. Perez-Oronoz, et al. 1993. Improved specificity of testing methods for filovirus antibodies. J. Virol. Methods 43:85-100.
163. Johnson, E. D., J. P. Gonzalez, and A. Georges. 1993. Haemorrhagic fever virus activity in equatorial Africa: Distribution and prevalence of filovirus reactive antibody in the Central African Republic. Trans. R. Soc. Trop. Med. Hyg. 87:530-535.
164. Johnson, E. D., J. P. Gonzalez, and A. Georges. 1993. Filovirus activity among selected ethnic groups inhabiting the tropical forest of equatorial Africa. Trans. R. Soc. Trop. Med. Hyg. 87:536-538.
165. Kalter, S. S., R. L. Heberling, J. D. Barry, et al. 1995. Detection of Ebola-Reston (Filoviridae) virus antibody by dotimmunobinding assay. Lab. Anim. Sci. 45:523-525.
166. McCarthy, M. C., R. L. Haberberger, A. W. Salib, et al. 1996. Evaluation of arthropod-borne viruses and other infectious disease pathogens as the causes of febrile illnesses in the Khartoum province of Sudan. J. Med. Virol. 48:141-146.
167. Hevey, M., D. Negley, J. Geisbert, et al. 1997. Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants. Virology 239:206-216.
168. Busico, K. M., K. L. Marshall, T. G. Ksiazek, et al. 1999. Prevalence of IgG antibodies to Ebola virus in individuals during an Ebola outbreak, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:102-107.
169. 2b for treatment of experimental Ebola virus infections. J. Infect. Dis. Suppl. 179:224-234.
170. Jezek, Z., M. Y. Szczeniowski, J. J. Muyembe-Tamfum, et al. 1999. Ebola between outbreaks: Intensified Ebola hemorrhagic fever surveillance in the Democratic Republic of the Congo. 1981-1985. J. Infect. Dis. Suppl. 179:60-64.
171. Ksiazek, T. G., P. E. Rollin, A. J. Williams, et al. 1999. Clinical virology of Ebola hemorrhagic fever (EHF): Virus, virus antigen, and IgG antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:177-187.
172. Ksiazek, T. G., C. P. West, P. E. Rollin, et al. 1999. ELISA for the detection of antibodies to Ebola viruses. J. Infect. Dis. Suppl. 179:192-198
173. Leirs, H., J. N. Mills, J. W. Krebs, et al. 1999. Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a vertebrate collection. J. Infect. Dis. Suppl. 179:155-163.
174. Tomori, O., J. Bertolli, P. E. Rollin, et al. 1999. Serologic survey among hospital and health center workers during the Ebola hemorrhagic fever outbreak in Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:98-101.
175. May, G., and H. Knothe. 1968. Bakteriologisch-virologische untersuchungen über die in Frankfurt/M. aufgetretenen menschlichen infektionen durch meerkatzen. Dtsch. Med. Wochenschr. 93:620-622.
176. Simpson, D. I. H., I. Zlotnik, and D. A. Rutter. 1968. Vervet monkey disease: Experimental infection of guinea pigs and monkeys with the causative agent. Br. J. Exp. Pathol. 49:458-464.
177. Slenczka, W., H.-L. Shu, G. Piepenburg, et al. 1968. Antigen-nachweis des "Marburg-virus" in den organen infizierter meerschweinchen durch immunfluoreszenz. Dtsch. Med. Wochenschr. 93:612-616.
178. Simpson, D. I. H. 1969. Vervet monkey disease transmission to the hamster. Br. J. Exp. Pathol. 50:389-392.
179. Simpson, D. I. H. 1969. Marburg agent disease: In monkeys. Trans. R. Soc. Trop. Med. Hyg. 63:303-309.
180. Bowen, E. T. W., G. S. Platt, D. I. H. Simpson, et al. 1978. Ebola haemorrhagic fever: Experimental infection of monkeys. Trans. R. Soc. Trop. Med. Hyg. 72:188-191.
181. Wulff, H., W. Slenczka, and J. H. S. Gear. 1978. Early detection of antigen and estimation of virus yield in specimens from patients with Marburg virus disease. Bull. WHO 56:633-639.
182. El Mekki, A. A. and G. van der Groen. 1981. A comparison of indirect immunofluorescence and electron microscopy for the diagnosis of some haemorrhagic viruses in cell cultures. J. Virol. Methods 3:61-69.
183. Moe, J. B., R. D. Lambert, and H. W. Lupton. 1981. Plaque assay for Ebola virus. J. Clin. Microbiol. 13:791-793.
184. Fisher - Hoch, S. P., G. S. Platt, G. H. Neild, et al. 1985. Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola). J. Infect. Dis. 152:887-894.
185. Rollin, P. E., T. G. Ksiazek, P. B. Jahrling, et al. 1990. Detection of Ebola-like viruses by immunofluorescence. Lancet 336:1591.
186. Ksiazek, T. G., P. E. Rollin, P. B. Jahrling, et al. 1992. Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates. J. Clin. Microbiol. 30:947-950.
187. Ryabchikova, E. I., L. A. Vorontsova, A. A. Skripchenko, et al. 1994. Damage to the internal organs of experimental animals infected with Marburgs virus. Bull. Exp. Biol. Med. 117:429-433.
188. Jaax, N., P. Jahrling, T. Geisbert, et al. 1995. Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. Lancet 346:1669-1671.
189. Johnson, E., N. Jaax, J. White, et al. 1995. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. Int. J. Exp. Pathol. 76:227-236.
190. Sanchez, A. and H. Feldmann. 1995. Detection of Marburg and Ebola virus infections by polymerase chain reaction assays, p. 411-418. In Y. Becher and G. Darai (eds.), PCR: Protocols for Diagnosis of Human and Animal Virus Diseases. Springer Verlag, Berlin, Germany.
191. Jaax, N. K., K. J. Davis, T. J. Geisbert, et al. 1996. Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch. Pathol. Lab. Med. 120:140-155.
192. Jahrling, P. B., J. Geisbert, J. R. Swearengen, et al. 1996. Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses. Arch. Virol. Suppl. 11:135-140.
193. Ryabchikova, E., L. Kolesnikova, M. Smolina, et al. 1996. Ebola virus infection in guinea pigs: Presumable role of granulomatous inflammation in pathogenesis. Arch. Virol. 141:909-921.
194. Ryabchikova, E., L. Strelets, L. Kolesnikova, et al. 1996. Respiratory Marburg virus infection in guinea pigs. Arch. Virol. 141:2177-2190.
195. Bray, M., K. Davis, T. Geisbert, et al. 1998. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178:651-661.
196. Conolly, B. M., K. E. Steele, K. J. Davis, et al. 1999. Pathogenesis of experimental Ebola virus infection in Guinea pigs. J. Infect. Dis. Suppl. 179:203-217.
197. Rodriguez, L. L., A. De Roo, Y. Guimard, et al. 1999. Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:170-176.
198. Wyers, M., P. Formenty, Y. Cherel, et al. 1999. Histopathological and immunohistochemical studies of lesions associated with Ebola virus in a naturally infected chimpanzee. J. Infect. Dis. Suppl. 179:54-59.
199. Zaki, S. R., W.-J. Shieh, P. W. Greer, et al. 1999. A novel immunohistochemical assay for the detection of Ebola virus in skin: Implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. J. Infect. Dis. Suppl. 179:36-47.
200. Baskerville, A., S. P. Fisher-Hoch, G. H. Neild, et al. 1985. Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection. J. Pathol. 147:199-209.
201. Geisbert, T. W., J. B. Rhoderick, and P. B. Jahrling. 1991. Rapid identification of Ebola virus and related filoviruses in fluid specimens using indirect immunoelectron microscopy. J. Clin. Pathol. 44:521-522.
202. Bechtelsheimer, H., H. Jacob, and H. Solcher. 1968. Zur neuropathologie der durch grüne meerkatzen (Cercopithecus aethiops) übertragenen infektionskrankheiten in Marburg. Dtsch. Med. Wochenschr. 93:602-604.
203. Gedigk, P., H. Bechtelsheimer, and G. Korb. 1968. Die pathologische anatomie der "Marburg-virus"-krankheit (sog. "Marburger Affenkrankheit"). Dtsch. Med. Wochenschr. 93:590-601.
204. Bechtelsheimer, H., G. Korb, and P. Gedigk. 1972. The morphology and pathogenesis of "Marburg virus" hepatitis. Hum. Pathol. 3:255-264.
205. Rippey, J. J., N. J. Schepers, and J. H. S. Gear. 1984. The pathology of Marburg virus disease. S. Afr. Med. J. 66:50-54.
206. Sureau, P. H. 1989. Firsthand clinical observations of hemorrhagic
207. Bwaka, M. A., M.-J. Bonnet, P. Calain, et al. 1999. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: Clinical observations in 103 patients. J. Infect. Dis. Suppl. 179:1-7.
208. Kibadi, K., K. Mupapa, K. Kuvula, et al. 1999. Late ophthalmologic manifestations in survivors of the 1995 Ebola virus epidemic in Kikwit, Democratic Republic of the Congo. J. Infect. Dis. Suppl. 179:13-14.
209. Mupapa, K., W. Mukundu, M. A. Bwaka, et al. 1999. Ebola hemorrhagic fever and pregnancy. J. Infect. Dis. Suppl. 179:11-12.
210. Mupapa, K., M. Massamba, K. Kibadi, et al. 1999. Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. J. Infect. Dis. Suppl. 179:18-23.
211. Rowe, A. K., J. Bertolli, A. S. Khan, et al. 1999. Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. J. Infect. Dis. Suppl. 179:28-35.
212. Volchkov, V. E., H. Feldmann, V. A. Volchkova, et al. 1998. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc. Natl. Acad. Sci. USA 95:5762-5767.
213. Shu, H. L., R. Siegert, and W. Slenczka. 1968. Zur pathogenese und epidemiologie der Marburg-virus-infektion. Dtsch. Med. Wochenschr. 93:2163-2165.
214. Siegert, R., H.-L. Shu, and W. Slenczka. 1968. Isolierung und identifizierung des "Marburg-virus". Dtsch. Med. Wochenschr. 93:604-612.
215. Zlotnik, I. 1969. Marburg agent disease: Pathology. Trans. R. Soc. Trop. Med. Hyg. 63:310-323.
216. Kissling, R. E., F. A. Murphy, and B. E. Henderson. 1970. Marburg virus. Ann. NY. Acad. Sci. 174:932-939.
217. Baskerville, A., E. T. W. Bowen, G. S. Platt, et al. 1978. The pathology of experimental Ebola virus infection in monkeys. J. Pathol. 125:131-138.
218. van der Groen, G., W. Jacob, and S. R. Pattyn. 1979. Ebola virus virulence for newborn mice. J. Med. Virol. 4:239-240.
219. Fisher-Hoch, S. P., G. S. Platt, G. Lloyd, et al. 1983. Haematological and biochemical monitoring of Ebola infection in rhesus monkeys: Implications for patient management. Lancet 2:(8358):1055-1058.
220. McCormick, J. B., S. P. Bauer, L. H. Elliott, et al. 1983. Biologic differences between strains of Ebola virus from Zaire and Sudan. J. Infect. Dis. 147:264-267.
221. Ryabchikova, E. I., L. V. Kolesnikova, and S. V. Luchko. 1999. An analysis of features of pathogenesis in two animal models of Ebola virus infection. J. Infect. Dis. Suppl. 179:199-202.
222. Renquist, D. Outbreak of simian hemorrhagic fever. 1990. J. Med. Primatol. 19:77-80.
223. Feldmann, H., H. Bugany, F. Mahner, et al. 1996. Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J. Virol. 70:2208-2214.
224. Harcourt, B. H., A. Sanchez, and M. K. Offermann. 1998. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Virology 252:179-188.
225. Ramanathan, C. S. and E. W. Taylor. 1997. Computational genomic analysis of hemorrhagic fever viruses. Viral selenoproteins as a potential factor in pathogenesis. Biol. Trace Elem. Res. 56:93-106.
226. Volchkov, V. E., V. M. Blinov, and S. V. Netesov. 1992. The envelope glycoprotein of Ebola virus contains an immunosuppressive-like domain similar to oncogenic retroviruses. FEBS Lett. 305:181-184.
227. Volchkov, V. E., V. A. Volchkova, W. Slenczka, et al. 1998. Release of viral glycoproteins during Ebola virus infection. Virology 245:110-119.
228. Monath, T. P. 1999. Ecology of Marburg and Ebola viruses: Speculations and directions for future research. J. Infect. Dis. Suppl. 179:127-138.
229. Breman, J. G., K. M. Johnson, G. van der Groen, et al. 1999. A search for Ebola virus in animals in the Democratic Republic of the Congo and Cameroon: Ecologic, virologic, and serologic surveys, 1979-1980. J. Infect. Dis. Suppl. 179:139-147.
230. Reiter, P., M. Turell, R. Coleman, et al. 1999. Field investigations of an outbreak of Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: Arthropod studies. J. Infect. Dis. Suppl. 179:148-154.
231. Ivanoff, B., P. Duquesnoy, G. Languillat, et al. 1982. Haemorrhagic fever in Gabon. I. Incidence of Lassa, Ebola and Marburg viruses in Haut-Ogooué. Trans. R. Soc. Trop. Med. Hyg. 76:719-720.
232. Tignor, G. H., J. Casals, and R. E. Shope. 1993. The yellow fever epidemic in Ethiopia, 1961-1962: Retrospective serological evidence for concomitant Ebola or Ebola-like virus infection. Trans. R. Soc. Trop. Med. Hyg. 87:162.
233. Johnson, K. M., C. L. Scribner, and J. B. McCormick. 1981. Ecology of Ebola virus: A first clue? J. Infect. Dis. 143:749-751.
234. Swanepoel, R., P. A. Leman, F. J. Burt, et al. 1996. Experimental inoculation of plants and animals with Ebola virus. Emerg. Infect. Dis. 2:321-325.
235. Turell, M. J., D. S. Bressler, and C. A. Rossi. 1996. Short report: Lack of virus replication in arthropods after intrathoracic inoculation of Ebola Reston virus. Am. J. Trop. Med. Hyg. 55:89-90.
236. Dowell, S. F., R. Mukunu, T. G. Ksiazek, et al. 1999. Transmission of Ebola hemorrhagic fever: A study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:87-91.
237. Centers for Disease Control and Prevention. 1995. Update: Management of patients with suspected viral hemorrhagic fever - United States. MMWR 44:475-479.
238. Kerstiëns, B. and F. Matthys. 1999. Interventions to control virus transmission during an outbreak of Ebola hemorrhagic fever: Experience from Kikwit, Democratic Republic of the Congo, 1995. J. Infect. Dis. Suppl. 179:263-267.
239. Muyembe-Tamfum, J. J., M. Kipasa, C. Kiyungu, et al. 1999. Ebola outbreak in Kikwit, Democratic Republic of the Congo: Discovery and control measures. J. Infect. Dis. Suppl. 179:259-262.
240. Butler, T. M., B. G. Brown, R. C. Dysko, et al. 1995. Medical Management, p. 255-334. In B. T. Bennett, C. R. Abee, and R. Henrickson (eds.), Nonhuman Primates in Biomedical Research. Academic Press, Inc., San Diego, CA.
241. Centers for Disease Control and Prevention. 1991. Update: Nonhuman primate importation. MMWR 40:684-685, 691.
242. DeMarcus, T. A., M. A. Tipple, and S. R. Ostrowski. 1999. US policy for disease control among imported nonhuman primates. J. Infect. Dis. Suppl. 179:281-282.
243. Centers for Disease Control and Prevention. 1990. Requirement for a special permit to import cynomolgus, African green, or rhesus monkeys into the United States. Fed. Regist. 55:15210-15211.
244. Rehbinder, C., P. Baneux, D. Forbes, et al. 1998. FELASA recommendations for health monitoring of breeding colonies and experimental units of cats, dogs and pigs. Lab. Anim. 31:1-17.
245. Peters, C. J., P. B. Jahrling, T. G. Ksiazek, et al. 1992. Filovirus contamination of cell cultures. Dev. Biol. Stand. 76:267-274.
246. Bannister, B. A. 1993. Stringent precautions are advisable when caring for patients with viral haemorrhagic fevers. Rev. Med. Virol. 3:3-6.
247. Huggins, J. W. 1989. Prospects for treatment of viral hemorrhagic fevers with Ribavirin, a broad-spectrum antiviral drug. Rev. Infect. Dis. Suppl. 11:750-761.
248. Kudoyarova - Zubavichene, N. M., N. N. Sergeyev, A. A. Chepurnov, et al. 1999. Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections. J. Infect. Dis. Suppl. 179:218-223.
249. Huggins, J., Z.-X. Zhang, and M. Bray. 1999. Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J. Infect. Dis. Suppl. 179:240-247.
250. Sadek, R. F., A. S. Khan, G. Stevens, et al. 1999. Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival. J. Infect. Dis. Suppl. 179:24-27.
251. Maruyama, T., P. W. H. I. Parren, A. Sanchez, et al. 1999. Recombinant human monoclonal antibodies to Ebola virus. J. Infect. Dis. Suppl. 179:235-239.
252. Lupton, H. W., R. D. Lambert, D. L. Bumgardner, et al. 1980. Inactivated vaccine for Ebola virus efficacious in guineapig model. Lancet 2:(8207):1294-1295.
253. Bray, M., K. Davis, T. Geisbert, et al. 1999. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. Suppl. 179:248-258.
254. Ignatyev, G. M., A. P. Agafonov, M. A. Streltsova, et al. 1996. Inactivated Marburg virus elicits a nonprotective immune response in rhesus monkeys. J. Biotechnol. 44:111-118.
255. Gilligan, K. J., J. B. Geisbert, P. B. Jahrling, et al. 1997. Assessment of protective immunity conferred by recombinant vaccinia viruses to guinea pigs challenged with Ebola virus, p. 87-92. In F. Brown (ed.), Vaccines 1997. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
256. Vanderzanden, L., M. Bray, D. Fuller, et al. 1998. DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge. Virology 246:134-144.
257. Xu, L., A. Sanchez, Z.-Y. Yang, et al. 1998. Immunization for Ebola virus infection. Nat. Med. 4:37-42.