A novel large plasmid carrying multiple β-lactam resistance genes isolated from a Klebsiella pneumoniae strain

Journal of Applied Microbiology

Volumn 88, Issue 6, 2000, Pages 1038-1048

  Li, L ^a   Lim, C K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CLONING; DNA; ELECTROPHORESIS; ESCHERICHIA COLI; STRAIN;

AMINOGLYCOSIDES; ANTIBIOTIC SUSCEPTIBILITY TESTS; CEFOTAXIME; CEFTAZIDIME; CLINICAL ISOLATES; KANAMYCINS; KLEBSIELLA PNEUMONIAE; LARGE PLASMIDS; PNEUMONIAE STRAINS; RESISTANCE GENES;

GENES;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFTAZIDIME;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; KLEBSIELLA PNEUMONIAE; NONHUMAN; PLASMID; PULSED FIELD GEL ELECTROPHORESIS; STRAIN DIFFERENCE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA;

EID: 0034044905     PISSN: 13645072     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2672.2000.01069.x     Document Type: Article

References (51)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipmen, D.J. (1990) Basic local alignment search tool. Journal of Molecular Biology 215, 403-410.
2. Arlet, G., Sanson-le Pors, M.J., Rouveau, M., Fournier, G., Marie, O., Schlemmer, B. and Philippon, A. (1990) Outbreak of nosocomial infections due to Klebsiella pneumoniae producing SHV-4 beta-lactamase. European Journal of Clinical Microbiology and Infectious Disease 9, 797-803.
3. Arlet, G., Rouveau, M., Casin, I., Bouvet, P.J., Lagrange, P.H. and Philippon, A. (1994) Molecular epidemiology of Klebsiella pneumoniae strains that produce SHV-4 beta-lactamase and which were isolated in 14 French hospitals. Journal of Clinical Microbiology 32, 2553-2558.
4. Bankier, A.T., Weston, K.M. and Barrell, B.G. (1987) Random cloning and sequencing by the M13 dideoxynucleotide chain termination method. Methods in Enzymology 155, 51-93.
5. Barthelemy, M., Peduzzi, J. and Labia, R. (1988) Complete amino acid sequence of p453-plasmid-mediated PIT-2 beta-lactamase (SHV-1). Biochemical Journal 251, 73-79.
6. Barton, B.M., Harding, G.P. and Zuccarelli, A.J. (1995) A general method for detecting and sizing large plasmids. Analytical Biochemistry 226, 235-240.
7. Bauernfeind, A., Rosenthal, E., Eberlein, E., Holley, M. and Schweighart, S. (1993) Spread of Klebsiella pneumoniae producing SHV-5 beta-lactamase among hospitalised patients. Infection 21, 18-22.
8. Bauernfeind, A., Stemplinger, I., Jungwirth, R., Mangold, P., Amann, S., Akalin, E., Ang, O., Bal, C. and Casellas, J.M. (1996) Characterisation of beta-lactamase gene blaPER-2, which encodes an extended-spectrum class A beta-lactamase. Antimicrobiol Agents and Chemotherapy 40, 616-620.
9. Bingen, E.H., Besjardins, P., Arlet, G., Bourgeois, F., Mariani-Kurkilpan, P., Lambert-Zechovsky, N.Y., Denamur, E., Philippon, A. and Ellion, J. (1993) Molecular epidemiology of plasmid spread among extended broad-spectrum beta-lactamase-producing δ lebsiella pneumoniae isolates in a paediatric hospital. Journal of Clinical Microbiology 31, 179-184.
10. Biswas, D., Datta, S., Ganguly, U., Pal, S.C. and Kumar, R. (1991) Expression of virulence and antibiotic resistance in an Escherichia coli transconjugant carrying a large plasmid pCAT120 of Shigella dysenteriae type I and its spontaneous fragmentations. Folia Microbiologica (Praha) 36, 127-135.
11. Di-Martino, P., Sirot, D., Joly, B., Rich, C. and Darfeuille-Michaud, A. (1997) Relationship between adhesion to intestinal Caco-2 cells and multidrug resistance in Klebsiella pneumoniae clinical isolates. Journal of Clinical Microbiology 35, 1499-1503.
12. French, G.L., Shannon, K.P. and Simmons, N. (1996) Hospital outbreak of Klebsiella pneumoniae resistant to broad-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations by hyperproduction of SHV-5 beta-lactamase. Journal of Clinical Microbiology 34, 358-363.
13. George, A.M., Hall, R.M. and Stokes, H.W. (1995) Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli. Microbiology 141, 1909-1920.
14. Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids. Journal of Molecular Biology 166, 557.
15. Hanahan, D., Jesse, J. and Bloom, F.R. (1995) DNA Cloning, Vol. 1. pp. 32-33. Oxford: IRL Press.
16. Holt, A. and Brown, D. (1989) Antimicrobial susceptibility testing. In Medical Bacteriology, a Practical Approach ed. Hawkey, P.M. and Lewis, D.A. pp. 167-194. Oxford: IRL Press.
17. Horii, T., Arakawa, Y., Ohta, M., Ichiyama, S., Wacharotayankun, R. and Kato, N. (1993) Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam. Antimicrobial Agents and Chemotherapy 37, 984-990.
18. Inglis, T.J., Kumarasinghe, G., Chow, C. and Liew, H.Y. (1994) Multiple antibiotic resistance in Klebsiella spp. & other Enterobacteriaceae isolated in Singapore. Singapore Medical Journal 35, 602-604.
19. Ish-Horowicz, D. and Burke, J.F. (1981) Rapid and efficient cosmic cloning. Nucleic Acids Research 9, 2989-2998.
20. Jacobs, G.A. and Han, P. (1996) Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. Journal of Clinical Microbiology 34, 908-911.
21. Jacoby, G.A. and Medeiros, A.A. (1991) More extended-spectrum beta-lactamases. Antimicrobial Agents and Chemotherapy 35, 1697-1704.
22. Jenks, P.J., Hu, Y.M., Danel, F., Mehtar, S. and Livermore, D.M. (1995) Plasmid-mediated production of class I (AmpC) beta-lactamase by two Klebsiella pneumoniae isolates from the UK. Journal of Antimicrobial Chemotherapy 35, 235-236.
23. Jones, R.N., Kehrberg, E.N., Erwin, M.E. and Anderson, S.C. (1994) Prevalence of important pathogens and antimicrobial activity of parental drugs at numerous medical centres in the United States, I. Study on the threat of emerging resistance: real or perceived? Fluoroquinolone Resistance Surveillance Group. Diagnostic Microbiology and Infectious Disease 19, 203-215.
24. Karmaker, S., Biswas, D., Shaikh, N.M., Chatterjee, S.K., Kataria, V.K. and Kumar, R. (1991) Role of a large plasmid of Salmonella typhi encoding multiple drug resistance. Journal of Medical Microbiology 34, 149-151.
25. Kumarasinghe, G., Liew, H.Y. and Chow, C. (1992a) Antimicrobial resistance: patterns and trends in the National University Hospital, Singapore (1989-91). Malaysian Journal of Pathology 14, 95-103.
26. Kumarasinghe, G., Lim, Y.S., Chow, C. and Bassett, D.C. (1992b) Prevalence of bacterial agents of diarrhoeal disease at the National University Hospital, Singapore and their resistance to antimicrobial agents. Tropical and Geographical Medicine 44, 229-232.
27. Lim, C.K., Smith, M.C.M., Petty, J., Bsumberg, S. and Wootton, J.C. (1989) Streptomyces griseus streptomycin phosphotransferase: Expression of its gene in Escherichia coli and sequence homology with other antibiotic phosphotransferases and with eukaryotic protein kinases. Journal of General Microbiology 135, 3289-3302.
28. Livermore, D.M. (1995) Beta-Lactamases in laboratory and clinical resistance. Clinical Microbiology Reviews 8, 557-584.
29. Luzzaro, F., Pagani, L., Porta, F. and Romero, E. (1995) Extended-spectrum beta-lactamases conferring resistance to monobactams and oxyimino-cephalosporins in clinical isolates of Serratia marcescens. Journal of Chemotherapy 7, 175-178.
30. Marchese, A., Arlet, G., Schito, G.C., Lagrange, P.H. and Philippon, A. (1996) Detection of SHV-5 extended-spectrum beta-lactamase in Klebsiella pneumoniae strains isolated in Italy. European Journal of Clinical Microbiology and Infectious Diseases 15, 245-248.
31. Marmur, J. (1961) A procedure for the isolation of deoxyribonucleic acid from microorganisms. Journal of Molecular Microbiology 3, 208-218.
32. Mayer, K.H., Opal, S.M. and Medeiros, A.A. (1995) Mechanisms of antibiotic resistance. In Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases 4th edn, ed. Mandell, G.L., Bennett, J.B. & Dolin, R. pp. 212-215. New York, NY: Churchill Livingstone Inc.
33. Medeiros, A.A. (1993) Nosocomial outbreaks of multiresistant bacteria. Extended-spectrum beta-lactamases have arrived in North America. Annals of Internal Medicine 1119, 428-430.
34. Meyer, K.S., Urban, C., Eagan, J.A., Berger, B.J. and Rahal, J.J. (1993) Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Annals of Internal Medicine 119, 353-358.
35. Montgomerie, J.Z., John, J.F., Atkins, L.M., Gilmore, D.S. and Ashley, M.A. (1993) Increased frequency of large R-plasmids in Klebsiella pneumoniae colonising patients with spinal cord injury. Diagnostic Microbiology and Infectious Disease 16, 25-29.
36. Payne, D.J. and Amyes, S.G. (1991) Transferable resistance to extended-spectrum beta-lactams: a major threat or a minor inconvenience? Journal of Antimicrobial Chemotherapy 27, 255-261.
37. Philippon, A., Redje, S.B., Fournier, G. and Hassen, A.B. (1989) Epidemiology of extended-spectrum beta-lactamases. Infection 17, 347-354.
38. Phipps, M., Pang, T., Koh, C.L. and Puthucheary, S. (1991) Plasmid incidence rate and conjugative chloramphenicol and tetracycline resistance plasmids in Malaysian isolates of Salmonella typhii. Microbiology and Immunology 35, 157-161.
39. Reed, C.S., Barrett, S.P., Threlfall, E.J. and Cheasty, T. (1995) Control of infection with multiple antibiotic resistant bacteria in a hospital renal unit: the value of plasmid characterisation. Epidemiology and Infection 115, 61-70.
40. Rice, L.B., Carias, L.L., Bonomo, R.A. and Shlaes, D.M. (1996) Molecular genetics of resistance to both ceftazidime and beta-lactam-beta-lactamase inhibitor combinations in Klebsiella pneumoniae and in vivo response to beta-lactam therapy. Journal of Infectious Diseases 173, 151-158.
41. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning, Vol. III. 2nd edn. pp. A.9-A.13. Cold Spring Harbor, NY: CSH Press.
42. Schiappa, D.A., Hayden, M.K., Matushek, M.G., Hashemi, F.N., Sullivan, J., Smith, K.Y., Miyashiro, D., Quinn, J.P., Weinstein, R.A. and Trenholme, G.M. (1996) Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: a case-control and molecular epidemiological investigation. Journal of Infectious Diseases 174, 529-536.
43. Scholz, P., Haring, V., Wittmann-Liebold, B., Ashman, K., Bagdasarian, M. and Scherzinger, E. (1989) Complete nucleotide sequence and gene organisation of the broad-host-range plasmid RSF1010. Gene 75, 271-288.
44. Shaw, K.J., Rather, P.N., Hare, R.S. and Miller, G.H. (1993) Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiological Reviews 57, 138-163.
45. Sirot, D., De Champs, C., Chanal, C., Labia, R., Darfeuille-Michaud, A., Perroux, R. and Sirot, J. (1991) Translocation of antibiotic resistance determinants including an extended-spectrum beta-lactamase between conjugative plasmids of Klebsiella pneumoniae and Escherichia coli. Antimicrobial Agents and Chemotherapy 35, 1576-1581.
46. Smith, C.L., Matsumoto, T., Niwa, O., Klco, S., Fan, J.B., Yanagida, M. and Cantor, C.R. (1987) An electrophoretic karyotype for Schizosaccharomyces pombe by pulsed field gel electrophoresis. Nucleic Acids Research 15, 4481-4489.
47. Sutcliffe, J.G. (1978) Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proceedings of the National Academy of Sciences of the United States of America 75, 3737-3741.
48. Urban, C., Meyer, K.S., Mariano, N., Rahal, J.J., Flamm, R., Rasmussen, B.A. and Bush, K. (1994) Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 38, 392-395.
49. Venezia, R.A., Scarano, F.J., Preston, K.E., Steele, L.M., Root, T.P., Limberger, R., Archinal, W. and Kacica, M.A. (1995) Molecular epidemiology of an SHV-5 extended-spectrum beta-lactamase in enterobacteriaceae isolated from infants in a neonatal intensive care unit. Clinical Infectious Diseases 21, 915-923.
50. Wallace, M.R., Johnson, A.P., Daniel, M., Malde, M. and Yousif, A.A. (1995) Sequential emergence of multi-resistant Klebsiella pneumoniae in Bahrain. Journal of Hospital Infection 31, 247-252.
51. Wang, F., Wang, Y. and Zhu, D. (1995) Drug resistant mechanism of clinical isolates of Klebsiella pneumoniae. Chung-Hua I Hsueh Tsa Chih 75, 60-61.