Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene

Mammalian Genome

Volumn 11, Issue 6, 2000, Pages 417-421

  Kitada, Tohru ^a,b   Asakawa, Shuichi ^b   Minoshima, Shinsei ^b   Mizuno, Yoshikuni ^a   Shimizu, Nobuyoshi ^b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE SEQUENCE; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PARKINSONISM; PROTEIN DOMAIN; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EMBRYO; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIGASES; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; UBIQUITIN-PROTEIN LIGASES;

EID: 0034044667     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010080     Document Type: Article

References (16)

1. Abass N, Lucking CB, Ricard S, Durr A, Bonifati V et al. (1999) A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. The French Parkinson's disease genetics study group and the European consortium on genetic susceptibility in Parkinson's disease. Hum Mol Genet 8, 567-574
2. Asaland R, Gibson TJ, Stewart AF (1996) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 20, 56-59
3. Boyer EL, Auburger G, Leube B, Ulm G, Mezey E et al. (1998) The ubiquitin pathway in Parkinson's disease. Nature 395, 451-452
4. Hattori N, Kitada T, Matsumine H, Asakawa S, Yamamura Y et al. (1998a) Molecular genetic analysis of a novel parkin gene in Japanese families with AR-JP: evidence for variable homozygous deletions in the parkin gene in affected individuals. Ann Neurol 44, 935-941
5. Hattori N, Matsumine H, Asakawa S, Kitada T, Yoshino H et al. (1998b) Point mutations (Thr240Arg and Gln311Stop) in the parkin gene. Biochem Biophys Res Commun 249, 754-758
6. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67, 425-479
7. Hochstrasser M (1997) Ubiquitin-dependent protein degradation. Annu Rev Genet 30, 405-439
8. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y et al. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608
9. Morett E, Bork P (1999) A novel transactivation domain in parkin. Trends Biochem Sci 24, 229-231
10. Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF et al. (1999) The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. J Biol Chem 274, 30963-30968
11. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press)
12. Saurin AJ, Borden KLB, Boddy MN, Freemont PS (1996) Does this have a familiar RING? Trends Biochem Sci 21, 208-214
13. Shimura H, Hattori N, Kubo S, Yoshikawa M, Kitada T et al. (1999) Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients. Ann Neurol 45, 668-672
14. Takahashi H, Ohama E, Suzuki S, Horikawa Y, Ishikawa A et al. (1994) Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology 44, 437-441
15. Yamamura Y, Kohriyama T, Kaseda Y, Nakamura S (1994) Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathological characteristics and nasological identification. Neurol Med (Tokyo) 41, 231-238
16. Yamamura Y, Kohriyama T, Kawakami H, Kaseda Y, Kuzuhara S, Nakamura S (1996) Autosomal recessive early-onset parkinsonism with diurnal fluctuation (AR-EPDF) - clinical characteristics. Clin Neurol (Tokyo) 36, 944-950