Sequential and multiple testing for dose-response analysis

Drug Information Journal

Volumn 34, Issue 2, 2000, Pages 591-597

  Lehmacher, Walter ^b   Kieser, Meinhard ^a   Hothorn, Ludwig ^c  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c NONE

Author keywords

Dose response; Interim analysis; Multiple testing

Indexed keywords

ARTICLE; DOSE RESPONSE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0034044377     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286150003400227     Document Type: Article

References (21)

1. Note for guidance on dose-response information to support drug registration. International Conference for Harmonization. Topic E, CPMP/ICH/378/95.
2. Tamhane AC, Hochberg Y, Dunnett CW. Multiple test procedures for dose finding. Biometrics. 1996; 52:21-37.
3. Phillips A. Sample size estimation when comparing more than two treatment groups. Drug Inf J. 1998; 32:193-200.
4. Phillips A. A review of the performance of tests used to establish whether there is a drug effect in dose-response studies. Drug Inf J. 1998;32:683-692.
5. Hothorn L, Lehmacher W. A simple testing procedure "control versus k treatments" for one-sided ordered alternatives, with application in toxicology. Biom J. 1991;33:179-189.
6. Kieser M, Lehmacher W. Multiple testing in clinical trials with interim analyses and a-priori ordered hypotheses. (Multiples Testen bei klinischen Prüfungen mit Zwischenauswertungen und a priori geordneten Hypothesen.) In: Trampisch HJ, Lange S. (eds.): Medical Research - Medical Practice. (Medizinische Forschung - Ärztliches Handeln.) Proceedings, MMV Medizin Verlag München. 1995; 162-165.
7. Maurer W, Hothorn L, Lehmacher W. Multiple comparisons in drug clinical trials and preclinical assays: a priori ordered hypotheses. In: Vollmar J (ed.). Biometrics in the Pharmaceutical Industry. (Biometrie in der chemisch-pharmazeutischen Industrie.) Stuttgart: Fischer: 1995;6:3-21.
8. Bauer P. A note on multiple testing procedures in dose finding. Biometrics. 1997;53:1125-1128.
9. Marcus R, Peritz E, Gabriel KR. On closed testing procedures with special reference to ordered analysis of variance. Biometrika. 1976;63:655-660.
10. Rom DM, Costello RJ, Connell LT. On closed test procedures for dose-response analysis. Stat Med. 1994;13:1583-1596.
11. Budde M, Bauer P. Multiple test procedures in clinical dose finding studies. J Am Stat Assoc. 1989;84: 792-796.
12. DeMets DL, Ware JH. Group sequential methods in clinicil trials with a one-sided hypothesis. Biometrika. 1980;67:651-660.
13. Bauer P, Budde M. Multiple testing for detecting efficient dose steps. Biom J. 1994;36:3-15.
14. Bauer P, Köhne K. Evaluation of experiments with adaptive interim analyses. Biometrics. 1994;50: 1029-1041.
15. Proschan MA, Hunsberger SA. Designed extension of studies based on conditional power. Biometrics. 1995;51:1315-1324.
16. Lehmacher W, Wassmer G. Adaptive sample size calculation in group sequential trials. Biometrics. 1999;55:1286-1290.
17. Bauer P, Röhmel J. An adaptive method for establishing a dose response relationship. Stat Med. 1995; 14:1595-1607.
18. Kieser M, Bauer P, Lehmacher W. Inference on multiple endpoints in clinical trials with adaptive interim analyses. Biom J. 1999;41:261-277.
19. Laakmann D, Schüle C, Baghai T, Kieser M. St. John's Wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry. 1998;31:54-59.
20. Hamilton M. A rating scale for depression. J Neurol Neuro-surgery Psychiatry. 1960;23:56-62.
21. Jonckheere AR. A distribution-free k sample test against ordered alternatives. Biometrika. 1954;41: 133-145.