Dual cytoarchitectonic trends: An evolutionary model of frontal lobe functioning and its application to psychopathology

Canadian Journal of Psychiatry

Volumn 45, Issue 3, 2000, Pages 247-256

  Christensen, Bruce K ^a,d   Bilder, Robert M ^b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Anxiety; Brain; Cognition; Cortex; Cytoarchitecture; Evolution; Frontal lobes; Hippocampus; Neurobiology; Neuropsychology; Psychopathology; Schizophrenia

Indexed keywords

ANXIETY NEUROSIS; BRAIN CORTEX; BRAIN FUNCTION; COGNITION; CYTOARCHITECTURE; EVOLUTION; FRONTAL LOBE; HIPPOCAMPUS; MENTAL DISEASE; MODEL; NERVE CELL; NEUROBIOLOGY; NEUROPSYCHOLOGY; NONHUMAN; PATHOGENESIS; REVIEW; SCHIZOPHRENIA;

EID: 0034042471     PISSN: 07067437     EISSN: None     Source Type: Journal    
DOI: 10.1177/070674370004500303     Document Type: Review

References (137)

1. Joseph R. Frontal lobe psychopathology: mania, depression, confabulation, catatonia, perseveration, obsessive compulsions, and schizophrenia. Psychiatry 1999;62:138-72.
2. Fuster JM. The prefrontal cortex. New York: Raven Press; 1989.
3. Goldman-Rakic PS. Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci 1988;11:137-56.
4. Stuss DT, Benson DF. The frontal lobes. New York: Raven Press; 1986.
5. Goldberg TE, Weinberger DR. Probing prefrontal function in schizophrenia with neuropsychological paradigms. Schizophr Bull 1988;14:179-83.
6. Levin S. Frontal lobe dysfunctions in schizophrenia - II. Impairments of psychological and brain functions. J Psychiatr Res 1984;18:57-72.
7. Robinson RG. Neuropsychiatric consequences of stroke. Annu Rev Med 1997;48:217-9.
8. Pantelis C, Barber FZ, Barnes TR, Nelson HE, Owen AM, Robbins TW. Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage. Schizophr Res 1999;37:251-70.
9. Matsushima E, Kojima T, Ohbayashi S, Ando H, Ando K, Shimazono Y. Exploratory eye movements in schizophrenic patients and patients with frontal lobe lesions. Eur Arch Psychiatry Clin Neurosci 1992;241:210-4.
10. Gron G. Auditory and visual working memory performance in patients with frontal lobe damage and schizophrenic patients with low scores on the Wisconsin Card Sorting Test. Psychiatry Research 1998;80(1):83-96.
11. Benes FM. Is there a neuroanatomic basis for schizophrenia? The Neuroscientist 1995;1:112-20.
12. Nemeroff CB, Musselman DL, Nathan Kl, Schatzberg AF, Knable MB, Kleinman JE, and others. Pathophysiological basis of psychiatric disorders. Focus on mood disorders and schizophrenia, in psychiatry. Tasman A, Kay J, Lieberman JA, editors. Philadelphia: Saunders; 1997. p 258-310.
13. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 1997;9:471-81.
14. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999;122(Pt 4):593-624.
15. Soares JC, Mann JJ. The functional neuroanatomy of mood disorders. J Psychiatr Res 1997;31:393-432.
16. Soares JC, Mann JJ. The anatomy of mood disorders - review of structural neuroimaging studies [comments]. Biol Psychiatry 1997;41:86-106.
17. Joel D, Weiner I, Feldon J. Electrolytic lesions of the medial prefrontal cortex in rats disrupt performance on an analog of the Wisconsin Card Sorting Test, but do not disrupt latent inhibition: implications for animal models of schizophrenia. Behav Brain Res 1997;85:187-201.
18. Waddington JL, Torrey EF. Schizophrenia, neurodevelopment, and disease. Archives of Psychiatry 1991;48:271-3.
19. Harrison PJ. Schizophrenia: a disorder of neurodevelopment? Curr Opin Neurobiol 1997;7:285-9.
20. Goodman SH, Gotlib IH. Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychol Rev 1999;106:458-90.
21. Dawson G, Frey K, Panagiotides H, Osterling J, Hessl D. Infants of depressed mothers exhibit atypical frontal brain activity: a replication and extension of previous findings. J Child Psychol Psychiatry 1997;38:179-86.
22. Graham YP, Heim C, Goodman SH, Miller AH, Nemeroff CB. The effects of neonatal stress on brain development: implications for psychopathology. Dev Psychopathol 1999;11:545-65.
23. Hyde IM, Ziegler JC, Weinberger DR. Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis [comments]. Arch Neurol 1992;49:401-6.
24. Lipska BK, Jaskiw GE, Weinberger DR. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 1993;9:67-75.
25. Lipska BK, Chrapusta SJ, Egan MF, Weinberger DR. Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol. Synapse 1995;20:125-30.
26. Bilder RM, Degreef G. Morphologic markers of neurodevelopmental paths to schizophrenia. In: Mednick SA, Cannon TD, Barr CE, LaFosse JM, editors. Developmental neuropathology of schizophrenia. New York: Plenum; 1991. p 167-90.
27. Bilder RM, Szesko PR. Structural neuroimaging and neuropsychological impairment. In: Pantelis C, Nelson HE, Barnes TRE, editors. The neuropsychology of schizophrenia. New York: Wiley; 1996. p 279-98.
28. Bilder RM. Neurocognitive impairment in schizophrenia and how it affects treatment options. Can J Psychiatry 1997;42:255-64.
29. Szeszko PR, Bilder RM, Dunlop JA, Walder DJ, Lieberman JA. Longitudinal assessment of methylphenidate effects on oral word production and symptoms in first-episode schizophrenia at acute and stabilized phases, Biol Psychiatry 1999;45:680-6.
30. Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M, and others. Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry 1999;56:913-9.
31. Gould SJ. Ontogeny and phylogeny. Cambridge: Belknap Press of Harvard University Press; 1985.
32. Stein DJ, Bouwer C. A neuro-evolutionary approach to the anxiety disorders. Journal of Anxiety Disorders 1997;11:409-29.
33. Tooby J, Cosmides L. Mapping the evolved functional organization of mind and brain. In: Gazzaniga MS, editor. The cognitive neurosciences. Cambridge: MIT Press; 1995. p 1185-97.
34. Vogt BA, Vogt O. Allgmeinere ergebnisse unserer himforschung. Journal fuer Psychologie and Neurologie 1919;25:279-461.
35. vonBonin G, Bailey P. The neocortex of Macaca mulatta. Urbana: University of Illinois Press; 1947.
36. Walker AE. A cytoarchitectural study of the prefrontal area of the macaque monkey. J Comp Neurol 1940;73:59-86.
37. Brodmann K. Vergleichende lokalisationlehre der grosshirninde in ihren prinzipien dargestellt auf grund de zellenbaues. Leipzig: Barth; 1909.
38. Sanides F. Comparative architectonics of the neocortex of mammals and their evolutionary interpretation. Ann N Y Acad Sci 1969;167:404-23.
39. Sanides F. Representation in the cerebral cortex and its areal lamination patterns. In: Bourne GH, editor. The structure and function of nervous tissue. Volume 5. New York: Academic Press; 1972.
40. Pandya DN, Barnes CL. Architecture and connections of the frontal lobe. In: Perecman E, editor. The frontal lobes revisited. New York: IBRN Press; 1987.
41. Pandya DN, Yeterian EH. Architecture and connection of the cortical association areas. In: Peters A, Jones EG. Cerebral cortex. Association and auditory cortices. Volume 4, New York: Plenum; 1985.
42. Barbas H, Pandya DN. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol 1989;286:353-75.
43. Pandya DN, Barnes CL. Architecture and connections of the premotor areas in the rhesus monkey. Behavioral and Brain Sciences 1985;8:595-7.
44. Barbas H, Pandya DN. Architecture and frontal cortical connections of the premotor cortex (area 6) in the rhesus monkey. J Comp Neurol 1987;256:211-28.
45. Goldberg G. Supplementary motor area: review and hypotheses. Behavioral and Brain Sciences 1985;8:567-88.
46. Goldberg G. Response and projection: a re-interpretation of the premotor concept. In: Roy EA, editor. Neuropsychological studies of apraxia and related disorders. Amsterdam: North Holland; 1985. p 251-66.
47. Goldberg G. From intent to action: evolution and function of the premotor systems of the frontal lobe. In: Perecman E, editor. The frontal lobes revisited. New York: IBRN Press; 1987.
48. Pandya DN, Kuypers HGJM. Corticocortical connections in the rhesus monkey. Brain Res 1969;13:13-36.
49. Damasio AR, VanHoesen GW, Vilensky J. Limbic-motor pathways in the primate: a means for emotion to influence motor behavior. Neurology 1981;31:60.
50. Schell GR, Strick PI. The origin of thalamic input to the arcuate premotor and supplementary motor areas. J Neurosci 1984;4:539-60.
51. Goldberg G, Mayer NH, Toglia JU. Medial frontal cortex infarction and the alien hand sign. Arch Neurol 1981;38:683-6.
52. Pandya DN, Seltzer B, Barbas H. Input-output organization of the primate cerebral cortex. In: Steklis HD, Erwin J, editors. Comparative primate biology. Neurosciences. Volume 4. New York: Alan R Liss; 1988.
53. Mishkin M. Visual mechanisms beyond the striate cortex. In: Russell R, editor. Frontiers in physiological psychology. New York: Academic Press; 1966.
54. Mishkin M. Cortical visual areas and their interaction. In: Karczmar G, Eccles JC. Brain and human behavior. New York: Springer-Verlag; 1972. p 187-208.
55. Ungerleider LG, Mishkin M. Two cortical visual systems. In: Ingle DJ, Goodale MA, Mansfield RJW, editor. Advances in the analysis of visual behavior. Cambridge: MIT Press; 1982. p 549-86.
56. Desimone R. Ungerleider I.G Nearal mechanisms of visual processing. In: Boller F. Grafman J. Handbook of neuropsychology New York: Elsevier; 1989.
57. Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, and others. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci U S A 1991;88:1621-5.
58. Haxby JV, Horwitz B, Ungerleider LG, Maisog JM, Pietrini P, Grady CL. The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations. J Neurosci 1994;14(11 Pt 1):6336-53.
59. Goodale MA, Milner AD. Separate visual pathways for perception and action. Trends Neurosci 1992;15:20-5.
60. Goodale MA, Meenan JP, Bulthoff HH, Nicolle DA, Murphy KJ, Racicot CI. Separate neural pathways for the visual analysis of object shape in perception and prehension. Curr Biol 1994;4:604-10.
61. Milner AD, Goodale MA. Visual pathways to perception and action. Prog Brain Res 1993;95:317-37.
62. Pribram KH, McGuiness D. Arousal, activation, and effort in the control of attention. Psychol Rev 1975;82:116-49.
63. McGuiness D, Pribram KH. The neuropsychology of attention: emotional and motivational controls. Wittrock MC, editor. New York: Adademic Press; 1980.
64. Kovelman JA, Scheibel AB. A neurohistological correlate of schizophrenia. Biol Psychiatry 1984;19:1601-21.
65. Scheibel AB, Kovelman JA. Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient [correspondence]. Biol Psychiatry 1981;16:101-2.
66. Jakob J, Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission 1986;65:303-26.
67. Dwork AJ. Postmortem studies of the hippocampal formation in schizophrenia. Schizophr Bull 1997;23:385-402.
68. Heinsen H, Gossmann E, Rub U, Eisenmenger W, Bauer M, Ulmar G, and others. Variability in the human entorhinal region may confound neuropsychiatric diagnoses. Acta Anat 1996;157:226-37.
69. Akil M, Lewis DA. Cytoarchitecture of the entorhinal cortex in schizophrenia. Am J Psychiatry 1997;154:1010-2.
70. Krimer LS, Herman MM, Saunders RC, Boyd JC, Hyde TM, Carter JM, and others. A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia. Cereb Cortex 1997;7:732-9.
71. Zaidel DW, Esiri MM, Harrison PJ. The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry. Psychol Med 1997;27:703-13.
72. Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991;48:996-1001.
73. Arnold SE, Franz BR, Gur RC, Gur RE, Shapiro RM, Moberg PJ, and others. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry 1995;152:738-48.
74. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry 1998;55:433-40.
75. Wu H, Strous R, Bilder RM, Alvir J, Ashtari M. Shape analysis of hippocampus in schizophrenia. Schizophr Res 1997;24:161.
76. Szeszko PR, Wu H, Ashtari M, Alvir J, Ma J, Crandall DT, and others. Left anterior hippocampal volume reductions in schizophrenia. Biol Psychiatry 1998;43:20S.
77. Csemansky JG, Joshi S, Wang L, Haller JW, Gado M, Miller JP, and others. Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci U S A 1998;95:11406-11.
78. Bilder RM, Bogerts B, Ashtari M, Wu H, Alvir JM, Jody D, and others. Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia. Schizophr Res 1995;17:47-58.
79. Benes FM, Majocha R, Bird ED. Marotta CA. Increased vertical axon numbers in cingulate cortex of schizophrenics. Arch Gen Psychiatry 1987;44:1017-21.
80. Benes FM, Bird ED. An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Arch Gen Psychiatry 1987;44:608-16.
81. Benes FM. Evidence for neurodevelopment disturbances in anterior cingulate cortex of post-mortem schizophrenic brain. Schizophr Res 1991;5:187-8.
82. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry 1995;52:805-18; discussion 819-20.
83. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence [comments]. Arch Gen Psychiatry 1986;43:114-24.
84. Andreasen NC, Swayze V, O'Leary DS, Nopoulos P, Cizadlo T, Harris G, and others. Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography. Eur Neuropsychopharmacol 1995;5(Suppl):37-41.
85. Early TS, Reiman EM, Raichle ME, Spitznagel EL. Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci U S A 1987;84:561-3.
86. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995;3:89-97.
87. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gruber SA, English CD, Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry 1996;153:200-5.
88. Bullmore ET, Frangou S, Murray RM. The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia. Schizophr Res 1997;28:143-56.
89. Woodruff PW, Wright IC, Shuriquie N, Russouw H, Rushe T, Howard RJ, and others. Structural brain abnormalities in male schizophrenics reflect fronto-temporal dissociation. Psychol Med 1997;27:1257-66.
90. Szeszko PR, Bilder RM, Lencz T, Pollack S, Alvir JM, Ashtari M, and others. Investigation of frontal lobe subregions in first-episode schizophrenia. Psychiatry Res 1999;90:1-15.
91. Buchsbaum MS. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990;16:379-89.
92. Buchsbaum MS. Frontal lobes, basal ganglia, temporal lobes - three sites for schizophrenia? Schizophr Bull 1990;16:377-8.
93. Bogerts B, Hantsch J, Herzer M. A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics. Biol Psychiatry 1983;18:951-69.
94. Bachevalier J, Alvarado MC, Malkova L. Memory and socioemotional behavior in monkeys after hippocampal damage incurred in infancy or in adulthood. Biol Psychiatry 1999;46:329-39.
95. Shapiro RM. Regional neuropathology in schizophrenia: where are we? Where are we going? Schizophr Res 1993;10:187-239.
96. Frith CD. Cognitive neuropsychology of schizophrenia. Hove (UK): Erlbaum; 1990.
97. Bilder RM, Szeszko PR. Structural neuroimaging and neuropsychological impairments. In: Pantelis C, Nelson HE, Barnes TRE, editors. The neuropsychology of schizophrenia. Sussex (UK): John Wiley & Sons; 1996.
98. Nuechterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenia disorders. Schizophr Bull 1984;10:160-203.
99. Comblatt BA, Risch NJ, Fans G, Friedman D, Erlenmeyer-Kimling L. The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 1988;26:223-38.
100. Steffy RA, Galbraith KJ. Relation between latency and redundancy-associated deficit in schizophrenic reaction time performance. J Abnorm Psychol 1980;89:419-27.
101. Galbraith KJ, MacCrimmon DJ, Steffy RA. Prepreparatory interval effects on redundancy deficit reaction time patterns in schizophrenic and normal subjects using the embedded-set procedure. J Nerv Ment Dis 1983;171:670-5.
102. Goldberg TE, Weinberger DR, Berman KF, Pliskin NH, Podd MH. Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test [comments]. Arch Gen Psychiatry 1987;44:1008-14.
103. Manschreck TC, Maher BA, Rucklos ME, Vereen DR Jr, Ader DN. Deficient motor synchrony in schizophrenia. J Abnorm Psychol 1981;90:321-8.
104. Manschreck TC, Maher BA, Rucklos ME, Vereen DR. Disturbed voluntary motor activity in schizophrenic disorder. Psychol Med 1982;12:73-84.
105. Manschreck TC. Psychopathology of motor behavior in schizophrenia. Progress in Experimental Personality Research 1983;12:53-99.
106. Manschreck TC, Keuthen NJ, Schneyer ML, Celada MT, Laughery J, Collins P. Abnormal involuntary movements and chronic schizophrenic disorders. Biol Psychiatry 1990;27:150-8.
107. Posner MI, Early TS, Reiman E, Pardo PJ, Dhawan M. Asymmetries in hemispheric control of attention in schizophrenia [comments]. Arch Gen Psychiatry 1988;45:814-21.
108. Lyon N, Mejsholm B, Lyon M. Stereotyped responding by schizophrenic outpatients: cross-cultural confirmation of perseverative switching on a two-choice task. J Psychiatr Res 1986;20:137-50.
109. Frith CD, Done DJ. Stereotyped responding by schizophrenic patients on a two-choice guessing task. Psychol Med 1983;13:779-86.
110. Place EJ, Gilmore GC. Perceptual organization in schizophrenia. J Abnorm Psychol 1980;89:409-18.
111. Wells DS, Leventhal D. Perceptual grouping in schizophrenia: replication of Place and Gilmore. J Abnorm Psychol 1984;93:231-4.
112. Kwapil TR, Hegley DC, Chapman LJ, Chapman JP. Facilitation of word recognition by semantic priming in schizophrenia. J Abnorm Psychol 1990;99:215-21.
113. Freedman R. Adler LE, Waldo MC, Pachtman E, Franks RD. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol Psychiatry 1983;18:537-51.
114. Braff DL, Geyer MA. Sensorimotor gating and schizophrenia. Human and animal model studies [comments] Arch Gen Psychiatry 1990;47:181-8.
115. Waldo MC, Carey G, Myles-Worsley M, Cawthra E, Adler LE, Nagamoto HT, and others. Codistribution of a sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Res 1991;39:257-68.
116. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 1992;49:975-82.
117. Sawaguchi T, Goldman-Rakic PS. D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science 1991;251:947-50.
118. Shakow D. Segmental set. Arch Gen Psychiatry 1962;6:1-17.
119. Cohen JD, Servan-Schreiber D. Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol Rev 1992;99:45-77.
120. Rauch SL. Savage CR, Alpert NM, Miguel EC, Baer L, Breiler HC, and others. A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry 1995;52:20-8.
121. Drevets WC, Videen TO, Snyder AZ, and others. Regional cerebral blood flow changes during anticipatory anxiety. Society for Neuroscience Abstracts 1994;20:368.
122. Zald DH, Kim SW. Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry; and obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1996;8:125-38.
123. Zald DH, Kim SW. Anatomy and function of the orbital frontal cortex, II: function and relevance to obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1996;8:249-61.
124. Abbruzzese M, Bellodi L, Ferri S, Scarone S. Frontal lobe dysfunction in schizophrenia and obsessive-compulsive disorder: a neuropsychological study. Brain Cogn 1995;27:202-12.
125. Schmidtke K, Schorb A, Winkelmann G, Hohagen F. Cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biol Psychiatry 1998;43:666-73.
126. Cox CS. Neuropsychological abnormalities in obsessive-compulsive disorder and their assessments. International Review of Psychiatry 1997;9:45-59.
127. Baxter LR, Jr., Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls [comments]. Arch Gen Psychiatry 1987;44:211-8. [Erratum. Arch Gen Psychiatry 1987;44:800.]
128. Baxter LR Jr, Schwartz JM, Mazziotta JC, Phelps ME, Pahl JJ, Guze BH, and others. Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am J Psychiatry 1988;145:1560-3.
129. Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN, and others. Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Arch Gen Psychiatry 1996;53:595-606.
130. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, and others. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography [comments]. Arch Gen Psychiatry 1994;51:62-70.
131. McGuire PK, Bench CJ, Frith CD, Marks IM, Frackowiak RS, Dolan RJ. Functional anatomy of obsessive-compulsive phenomena. Br J Psychiatry 1994;164:459-68.
132. Benkelfat C, Nordahl TE, Semple WE, King AC, Murphy DL, Cohen RM. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch Gen Psychiatry 1990;47:840-8.
133. Perani D, Colombo C, Bressi S, Bonfanti A, Grassi F, Scarone S, and others. [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br J Psychiatry 1995;166:244-50.
134. Gray JA. Precis of the neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system. Behavioral and Brain Sciences 1982;5:459-534.
135. Gray JA. The neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system. New York: Oxford University Press; 1982.
136. Deutch AY, Ongur D, Duman RS. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Neuroscience 1995;66:337-46.
137. Deutch AY, Duman RS. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Neuroscience 1996;70:377-89.