Rapid expansion from supercritical to aqueous solution to produce submicron suspensions of water-insoluble drugs

Biotechnology Progress

Volumn 16, Issue 3, 2000, Pages 402-407

  Young, Timothy J ^a   Mawson, Simon ^a   Johnston, Keith P ^a   Henriksen, Inge B ^b   Pace, Gary W ^c   Mishra, Awadhesh K ^c  

^a The University of Texas at Austin   (United States)

^b RF Rogaland Research   (Norway)

^c RTP Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AQUEOUS SOLUTION; CYCLOSPORIN; DRUG SOLUBILITY; PARTICLE AGGLOMERATION; PARTICLE SIZE; PARTICLE; POLYSORBATE 80; SUPERCRITICAL FLUID; SURFACTANT;

AGGLOMERATION; SOLUBILITY; SOLUTIONS; SUPERCRITICAL FLUIDS; SURFACE ACTIVE AGENTS; SUSPENSIONS (FLUIDS); WATER;

CYCLOSPORINE; FREE JET EXPANSION; RAPID EXPANSION FROM SUPERCRITICAL TO AQUEOUS SOLUTION; WATER INSOLUBLE DRUGS;

DRUG PRODUCTS;

CYCLOSPORINE; PARTICLE SIZE; SOLUBILITY; SOLUTIONS; WATER;

EID: 0034042048     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp000032q     Document Type: Article

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