-
1
-
-
0024805699
-
Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR-1065
-
A. T. M. Vaughan, D. J. Grdina, P. J. Meechan, A. E. Milner and D. J. Gordon, Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR-1065. Br. J. Cancer 60, 893-896 (1989).
-
(1989)
Br. J. Cancer
, vol.60
, pp. 893-896
-
-
Vaughan, A.T.M.1
Grdina, D.J.2
Meechan, P.J.3
Milner, A.E.4
Gordon, D.J.5
-
2
-
-
0028343712
-
Inhibition of topoisomerase I alpha activity in CHO K1 cells by WR-1065
-
D. J. Grdina, A. Constantinou, N. Shigematsu and J. S. Murley, Inhibition of topoisomerase I alpha activity in CHO K1 cells by WR-1065. Radiat. Res. 138, 44-52 (1994).
-
(1994)
Radiat. Res.
, vol.138
, pp. 44-52
-
-
Grdina, D.J.1
Constantinou, A.2
Shigematsu, N.3
Murley, J.S.4
-
3
-
-
0028103722
-
Radiosensitivity of polyamine-depleted HeLa cells and modulation by aminothiol WR-1065
-
R. D. Snyder and K. K. Schroeder, Radiosensitivity of polyamine-depleted HeLa cells and modulation by aminothiol WR-1065. Radiat. Res. 137, 67-75 (1994).
-
(1994)
Radiat. Res.
, vol.137
, pp. 67-75
-
-
Snyder, R.D.1
Schroeder, K.K.2
-
4
-
-
0019304979
-
The role of WR-2721 in radiotherapy and/or chemotherapy
-
J. M. Yuhas, J. M. Spellman and F. Culo, The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clin. Trials 3, 211-216 (1980).
-
(1980)
Cancer Clin. Trials
, vol.3
, pp. 211-216
-
-
Yuhas, J.M.1
Spellman, J.M.2
Culo, F.3
-
5
-
-
0019153168
-
Rationale for initial clinical trials and future development of radioprotectants
-
T. L. Phillips, Rationale for initial clinical trials and future development of radioprotectants. Cancer Clin. Trials 3, 165-173 (1980).
-
(1980)
Cancer Clin. Trials
, vol.3
, pp. 165-173
-
-
Phillips, T.L.1
-
6
-
-
0021796650
-
The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells
-
D. J. Grdina, B. Nagy, C. K. Hill, L. Wells and C. Peraino, The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis 6, 929-939 (1985).
-
(1985)
Carcinogenesis
, vol.6
, pp. 929-939
-
-
Grdina, D.J.1
Nagy, B.2
Hill, C.K.3
Wells, L.4
Peraino, C.5
-
8
-
-
0025222079
-
Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278
-
E. A. Holwitt, E. Koda and C. E. Swenberg, Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278. Radiat. Res. 124, 107-109 (1990).
-
(1990)
Radiat. Res.
, vol.124
, pp. 107-109
-
-
Holwitt, E.A.1
Koda, E.2
Swenberg, C.E.3
-
9
-
-
0024501401
-
The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair
-
D. J. Grdina, C. P. Sigdestad, P. J. Dale and J. M. Perrin, The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair. Br. J. Cancer 59, 17 (1989).
-
(1989)
Br. J. Cancer
, vol.59
, pp. 17
-
-
Grdina, D.J.1
Sigdestad, C.P.2
Dale, P.J.3
Perrin, J.M.4
-
10
-
-
0028889590
-
Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065
-
G. E. Woloschak, T. Paunesku, C. Chang-Liu and D. J. Grdina, Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065. Cancer Res. 55, 4788-4792 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4788-4792
-
-
Woloschak, G.E.1
Paunesku, T.2
Chang-Liu, C.3
Grdina, D.J.4
-
11
-
-
84990617909
-
Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors
-
C. P. Sigdestad, W. Guilford, J. Perrin and D. J. Grdina, Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors. Cell Tissue Kind. 21, 193-200 (1988).
-
(1988)
Cell Tissue Kind.
, vol.21
, pp. 193-200
-
-
Sigdestad, C.P.1
Guilford, W.2
Perrin, J.3
Grdina, D.J.4
-
12
-
-
0026588374
-
N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death
-
N. Ramakrishnan and G. N. Catravas, N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death. J. Immunol. 148, 1817-1821 (1992).
-
(1992)
J. Immunol.
, vol.148
, pp. 1817-1821
-
-
Ramakrishnan, N.1
Catravas, G.N.2
-
13
-
-
0030819829
-
Modulation of radiation-induced apoptosis by thiolamines
-
R. L. Warters, J. C. Roberts, B. H. Wilmore and L. L. Kelley, Modulation of radiation-induced apoptosis by thiolamines. Int. J. Radiat. Biol. 72, 439-448 (1997).
-
(1997)
Int. J. Radiat. Biol.
, vol.72
, pp. 439-448
-
-
Warters, R.L.1
Roberts, J.C.2
Wilmore, B.H.3
Kelley, L.L.4
-
14
-
-
0000091840
-
Chemical protection against ionizing radiation
-
J. C. Livesey and D. J. Reed, Chemical protection against ionizing radiation. Adv. Radiat. Biol. 13, 285-353 (1987).
-
(1987)
Adv. Radiat. Biol.
, vol.13
, pp. 285-353
-
-
Livesey, J.C.1
Reed, D.J.2
-
15
-
-
0027930460
-
Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells
-
K. D. Held and J. E. Biaglow, Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Radiat. Res. 139, 15-23 (1994).
-
(1994)
Radiat. Res.
, vol.139
, pp. 15-23
-
-
Held, K.D.1
Biaglow, J.E.2
-
16
-
-
0026552891
-
The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation
-
D. J. Grdina, Y. Kataoka, I. Basic and J. Perrin, The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis 13, 811-814 (1992).
-
(1992)
Carcinogenesis
, vol.13
, pp. 811-814
-
-
Grdina, D.J.1
Kataoka, Y.2
Basic, I.3
Perrin, J.4
-
17
-
-
0023679159
-
Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug
-
P. M. Calabro-Jones, J. A. Aguilera, J. F. Ward, G. D. Smoluk and R. C. Fahey, Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug. Cancer Res. 48, 3634-3640 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 3634-3640
-
-
Calabro-Jones, P.M.1
Aguilera, J.A.2
Ward, J.F.3
Smoluk, G.D.4
Fahey, R.C.5
-
18
-
-
0023793476
-
Radioprotection of cells in culture by WR-2721 and derivatives: Form of the drug responsible for protection
-
G. D. Smoluk, R. C. Fahey, P. M. Calabro-Jones, J. A. Aguilera and J. F. Ward, Radioprotection of cells in culture by WR-2721 and derivatives: Form of the drug responsible for protection. Cancer Res. 48, 3634-3640 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 3634-3640
-
-
Smoluk, G.D.1
Fahey, R.C.2
Calabro-Jones, P.M.3
Aguilera, J.A.4
Ward, J.F.5
-
19
-
-
0028953642
-
Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-toxic and anti-mutagenic mechanisms of action
-
D. J. Grdina, N. Shigematsu, P. Dale, G. L. Newton, J. A. Aguilera and R. C. Fahey, Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-toxic and anti-mutagenic mechanisms of action. Carcinogenesis 18, 767-774 (1995).
-
(1995)
Carcinogenesis
, vol.18
, pp. 767-774
-
-
Grdina, D.J.1
Shigematsu, N.2
Dale, P.3
Newton, G.L.4
Aguilera, J.A.5
Fahey, R.C.6
-
20
-
-
0026068696
-
Polyamine-DNA nexus: Structural ramifications and biological implications
-
D. Balasundaram and A. K. Tyagi, Polyamine-DNA nexus: structural ramifications and biological implications. Mol. Cell. Biochem. 100, 129-140 (1991).
-
(1991)
Mol. Cell. Biochem.
, vol.100
, pp. 129-140
-
-
Balasundaram, D.1
Tyagi, A.K.2
-
21
-
-
0029980119
-
Polyamine-induced compaction and aggregation of DNA - A major factor in radioprotection of chromatin under physiological conditions
-
G. L. Newton, J. A. Aguilera, J. F. Ward and R. C. Fahey, Polyamine-induced compaction and aggregation of DNA - A major factor in radioprotection of chromatin under physiological conditions. Radiat. Res. 145, 776-780 (1996).
-
(1996)
Radiat. Res.
, vol.145
, pp. 776-780
-
-
Newton, G.L.1
Aguilera, J.A.2
Ward, J.F.3
Fahey, R.C.4
-
22
-
-
0026517245
-
Effects of salt concentration and H1 histone removal on the differential scanning calorimetry of nuclei
-
N. A. Touchette and R. D. Cole, Effects of salt concentration and H1 histone removal on the differential scanning calorimetry of nuclei. Biochemistry 31, 1842-1849 (1992).
-
(1992)
Biochemistry
, vol.31
, pp. 1842-1849
-
-
Touchette, N.A.1
Cole, R.D.2
-
23
-
-
0024507005
-
Structural domains and conformational changes in nuclear chromatin: A quantitative thermodynamic approach by differential scanning calorimetry
-
C. Balbi, M. L. Abelmoschi, L. Gogioso, S. Parodi, P. Barboro, B. Cavazza and E. Patrone, Structural domains and conformational changes in nuclear chromatin: A quantitative thermodynamic approach by differential scanning calorimetry. Biochemistry 28, 3220-3227 (1989).
-
(1989)
Biochemistry
, vol.28
, pp. 3220-3227
-
-
Balbi, C.1
Abelmoschi, M.L.2
Gogioso, L.3
Parodi, S.4
Barboro, P.5
Cavazza, B.6
Patrone, E.7
-
25
-
-
0015403570
-
Phospholipid orientation in sarcoplasmic membranes: Spin label ESR and protein NMR studies
-
S. Eletr and G. Inesi. Phospholipid orientation in sarcoplasmic membranes: Spin label ESR and protein NMR studies. Biochim. Biophys. Acta 282, 174-179 (1972).
-
(1972)
Biochim. Biophys. Acta
, vol.282
, pp. 174-179
-
-
Eletr, S.1
Inesi, G.2
-
26
-
-
0030610918
-
2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37°C
-
2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37°C. Biochemistry 36, 11002-11011 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 11002-11011
-
-
Senisterra, G.A.1
Huntley, S.A.2
Escaravage, M.3
Sekhar, K.R.4
Freeman, M.5
Borrelli, M.6
Lepock, J.R.7
-
28
-
-
0027199872
-
Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock
-
J. R. Lepock, H. E. Frey and K. P. Ritchie, Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock. J. Cell Biol. 122, 1267-1276 (1993).
-
(1993)
J. Cell Biol.
, vol.122
, pp. 1267-1276
-
-
Lepock, J.R.1
Frey, H.E.2
Ritchie, K.P.3
-
29
-
-
0027170257
-
Protein aggregation as primary and characteristic cell reaction to various stresses
-
A. E. Kabakov and V. L. Gabai, Protein aggregation as primary and characteristic cell reaction to various stresses. Experientia 49, 706-710 (1993).
-
(1993)
Experientia
, vol.49
, pp. 706-710
-
-
Kabakov, A.E.1
Gabai, V.L.2
-
30
-
-
0029741151
-
Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei
-
G. L. Newton, J. A. Aguilera, J. F. Ward and R. C. Fahey, Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei. Radiat. Res. 146, 298-305 (1996).
-
(1996)
Radiat. Res.
, vol.146
, pp. 298-305
-
-
Newton, G.L.1
Aguilera, J.A.2
Ward, J.F.3
Fahey, R.C.4
-
31
-
-
0023084124
-
Formation of disullides with diamide
-
N. S. Kosower and E. M. Kosower, Formation of disullides with diamide. Methods Enzymol. 143, 264-270 (1987).
-
(1987)
Methods Enzymol.
, vol.143
, pp. 264-270
-
-
Kosower, N.S.1
Kosower, E.M.2
-
32
-
-
0029089408
-
Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor
-
M. L. Freeman, M. J. Borrelli, K. Syed, G. Senisterra, D. M. Stafford and J. R. Lepock, Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor. J. Cell. Physiol. 164, 356-366 (1995).
-
(1995)
J. Cell. Physiol.
, vol.164
, pp. 356-366
-
-
Freeman, M.L.1
Borrelli, M.J.2
Syed, K.3
Senisterra, G.4
Stafford, D.M.5
Lepock, J.R.6
-
33
-
-
0018192572
-
The effects of hyperthermia on the protein-to-DNA ratio of isolated HeLa cell chromatin
-
J. L. Roti Roti and R. T. Winward, The effects of hyperthermia on the protein-to-DNA ratio of isolated HeLa cell chromatin. Radiat. Res. 74, 159-169 (1978).
-
(1978)
Radiat. Res.
, vol.74
, pp. 159-169
-
-
Roti Roti, J.L.1
Winward, R.T.2
-
34
-
-
0031008887
-
Proteins containing non-native disullide bonds generated by oxidative stress act as signals for induction of the heat shock response
-
A. T. McDuffec, G. Senisterra, S. Huntley, J. R. Lepock, K. R. Sekhar, M. J. Meredith, M. J. Borrelli, J. D. Morrow and M. L. Freeman, Proteins containing non-native disullide bonds generated by oxidative stress act as signals for induction of the heat shock response. J. Cell. Physiol. 171, 143-151 (1997).
-
(1997)
J. Cell. Physiol.
, vol.171
, pp. 143-151
-
-
McDuffec, A.T.1
Senisterra, G.2
Huntley, S.3
Lepock, J.R.4
Sekhar, K.R.5
Meredith, M.J.6
Borrelli, M.J.7
Morrow, J.D.8
Freeman, M.L.9
-
35
-
-
0030818349
-
Destabilization and denaturation of cellular protein by glutathione depletion
-
M. L. Freeman, S. A. Huntley, M. J. Meredith, G. A. Senisterra and J. R. Lepock, Destabilization and denaturation of cellular protein by glutathione depletion. Cell Stress Chaperones 2, 191-198 (1997).
-
(1997)
Cell Stress Chaperones
, vol.2
, pp. 191-198
-
-
Freeman, M.L.1
Huntley, S.A.2
Meredith, M.J.3
Senisterra, G.A.4
Lepock, J.R.5
-
36
-
-
0038664982
-
On the mode of action of X-ray protective agents
-
L. Eldjarn and A. Pihl, On the mode of action of X-ray protective agents. J. Biol. Chem. 225, 499-510 (1956).
-
(1956)
J. Biol. Chem.
, vol.225
, pp. 499-510
-
-
Eldjarn, L.1
Pihl, A.2
-
37
-
-
0023761710
-
Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression
-
D. J. Grdina, W. H. Guilford, C. P. Sigdestad and C. S. Giometti, Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression. Pharmacol. Ther. 39, 133-137 (1988).
-
(1988)
Pharmacol. Ther.
, vol.39
, pp. 133-137
-
-
Grdina, D.J.1
Guilford, W.H.2
Sigdestad, C.P.3
Giometti, C.S.4
-
38
-
-
0026087081
-
Association of WR-1065 with CHO AA8 cells, nuclei, and nucleoids
-
P. J. Meechan, A. T. M. Vaughan, C. S. Giometti and D. J. Grdina, Association of WR-1065 with CHO AA8 cells, nuclei, and nucleoids. Radiat. Res. 125, 152-157 (1991).
-
(1991)
Radiat. Res.
, vol.125
, pp. 152-157
-
-
Meechan, P.J.1
Vaughan, A.T.M.2
Giometti, C.S.3
Grdina, D.J.4
-
39
-
-
0030007686
-
Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins
-
M. J. Borrelli, J. R. Lepock, H. E. Frey, Y. J. Lee and P. M. Corry, Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins. J. Cell. Physiol. 167, 369-379 (1996).
-
(1996)
J. Cell. Physiol.
, vol.167
, pp. 369-379
-
-
Borrelli, M.J.1
Lepock, J.R.2
Frey, H.E.3
Lee, Y.J.4
Corry, P.M.5
-
40
-
-
0022513251
-
Equilibrium dialysis studies of the binding of radioprotector compounds to DNA
-
G. D. Smoluk, R. C. Fahey and J. F. Ward, Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiat. Res. 107, 194-204 (1986).
-
(1986)
Radiat. Res.
, vol.107
, pp. 194-204
-
-
Smoluk, G.D.1
Fahey, R.C.2
Ward, J.F.3
-
41
-
-
0343814087
-
Histone function and evolution as viewed by sequence studies
-
R. J. Delange and E. L. Smith, Histone function and evolution as viewed by sequence studies. CIBA Found. Symp. 28, 59-70 (1975).
-
(1975)
CIBA Found. Symp.
, vol.28
, pp. 59-70
-
-
Delange, R.J.1
Smith, E.L.2
-
42
-
-
0029143136
-
Thiazolidine prodrugs of cysteamine and cysteine as radioprotective agents
-
J. C. Roberts, K. E. Koch, S. R. Detrick, R. L. Warters and G. Lubec, Thiazolidine prodrugs of cysteamine and cysteine as radioprotective agents. Radiat. Res. 143, 203-213 (1995).
-
(1995)
Radiat. Res.
, vol.143
, pp. 203-213
-
-
Roberts, J.C.1
Koch, K.E.2
Detrick, S.R.3
Warters, R.L.4
Lubec, G.5
-
43
-
-
0024550538
-
The relationship of increased nuclear protein content induced by hyperthermia to killing of HeLa S3 cells
-
H. H. Kampinga, N. T. Turkel-Uygur, J. L. Roti Roti and A. W. T. Konings, The relationship of increased nuclear protein content induced by hyperthermia to killing of HeLa S3 cells. Radiat. Res. 117, 511-522 (1989).
-
(1989)
Radiat. Res.
, vol.117
, pp. 511-522
-
-
Kampinga, H.H.1
Turkel-Uygur, N.T.2
Roti Roti, J.L.3
Konings, A.W.T.4
|