FD-891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte-mediated cytotoxicity through the blockage of conjugate formation

Immunology

Volumn 100, Issue 2, 2000, Pages 170-177

  Kataoka, T ^a   Yamada, A ^a   Bando, M ^a   Honma, T ^a   Mizoue, K ^b   Nagai, K ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; BLOCKING AGENT; CELL SURFACE RECEPTOR; CONCANAMYCIN A; FAS LIGAND; FD 891; MACROLIDE; MONOCLONAL ANTIBODY CD3; PERFORIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL GRANULE; CELL VACUOLE; COMPETITIVE INHIBITION; CONJUGATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG RECEPTOR BINDING; EFFECTOR CELL; EXOCYTOSIS; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; LYMPHOCYTOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TARGET CELL DESTRUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGENS, CD3; ANTIGENS, CD95; CYTOTOXICITY, IMMUNOLOGIC; EXOCYTOSIS; FAS LIGAND PROTEIN; HYDROGEN-ION CONCENTRATION; LIGANDS; MACROLIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; VACUOLES;

EID: 0034040466     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00039.x     Document Type: Article

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