The effect of Helicobacter pylori on cell proliferation and apoptosis in gastric epithelial cell lines

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 14, Issue 1, 2000, Pages 188-192

  Takagi, A ^a   Watanabe, S ^a   Igarashi, M ^a   Koike, J ^a   Hasumi, K ^a   Deguchi, R ^a   Koga, Y ^a   Miwa, T ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; BACTERIAL TOXIN; CYTOTOXIN; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CELL VACUOLE; CONFERENCE PAPER; CONTROLLED STUDY; EPITHELIUM CELL; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HELICOBACTER PYLORI INFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH EPITHELIUM; STOMACH INJURY;

EID: 0034038880     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.014s1188.x     Document Type: Conference Paper

References (20)

1. Blaser MJ, Parsonet J. Parasitism by the slow bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 1994; 94: 4-8.
2. Wagner S, Beil W, Westermann J, et al. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology 1997; 115: 1836-47.
3. Knipp U, Birkholz S, Kaup W, Opferkuch W. Partial characterization of a cell proliferation-inhibiting protein produced by Helicobacter pylori. Infect Immun 1996; 64: 3491-6.
4. Takagi A, Watanabe S, Igarashi M, et al. Helicobacter pylori induces gastric mucosal injury independently of vacuolating cytotoxin. Gastroenterology 1998; 114: A301 (Abstract).
5. Greenblatt MS, Bennet WP, Hollstein M, Harris CC. Mutation in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78.
6. Chen G, Sordillo EM, Ramey WG, et al. Apotosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of Bak. Biochem Biophys Res Commun 1997; 239: 626-32.
7. Cover TL, Berg DE, Blaser MJ. VacA and cag pathogenicity island of H. pylori. In: Ernst PB, Michetti P, Smith PD, eds. The Immunobiology of H. Pylori: from Pathogenesis to Prevention. Philadelphia: Lippincott-Raven., 1997: 75-90.
8. De Bernard M, Papini E, de Filippis V, et al. Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant. J Biol Chem 1995; 270: 23937-40.
9. Takagi A, Kamiya S, Koga Y, et al. Analysis of interleukin-8 secretion induced by Helicobacter pylori from the gastric epithelial cell line MKN 45: a mechanism independent of the intensity of cytotoxicity. J Gastroenterol Hepatol 1997; 12: 368-72.
10. Brenes F, Ruiz B, Correa P, et al. Helicobacter pylori causes hyperproliferation of gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 1993; 88: 1870-5.
11. Jones NL, Shannon PT, Cutz E, Yeger H, Sherman PM. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am J Pathol 1997; 151: 1695-703.
12. Ochiai A, Yamaaguchi Y, Hirohashi S. P53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia. Int J Cancer 1996; 69: 28-33.
13. Sawaoka H, Kawano S, Tsuji S, et al. Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. Prostaglandins Leukotr Essent Fatty Acids 1998; 59: 313-6.
14. Romano M, Ricci V, Memoli A, et al. Helicobacter pylori up-regulates cyclooxygenase-2 mRNA expression and prostaglandin E2 synthesis in MKN 28 gastric suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78.
15. Bamford KB, Hunt R, Muller M, Ernst PB. Gastric T cells and H. pylori, regulation of pathegenesis and prevention. In: Ernst PB, Michetti P, Smith PD eds. The Immunobiology of H. Pylori: from Pathogenesis to Prevention. Philadelphia: Lippincott-Raven, 1997: 227-35.
16. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori-associated gastritis. Gut 1991; 32: 1475-7.
17. Harris PR, Mobley HL, Perez-Perez GI, Blaser MJ, Smith PD. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996; 111: 419-25.
18. Karttunen R, Karttunen T, Erke H-PT, MacDonald TT. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 1995; 36: 341-5.
19. Atherton JC, Peek RM, Tham KT, Cover TL, Blase MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter Pylori. Gastroenterology 1997; 112: 92-9.
20. Cover TL, Hanson P, Heuser JE. Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J Cell Biol 1997; 138: 759-69.