Impaired β-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients

Clinical Endocrinology

Volumn 52, Issue 5, 2000, Pages 549-555

  Kasayama, Soji ^a   Otsuki, Michio ^a   Takagi, Miki ^a   Saito, Hiroshi ^a   Sumitani, Satoru ^a   Kouhara, Haruhiko ^a   Koga, Masafumi ^b   Saitoh, Youichi ^a   Ohnishi, Takanori ^a   Arita, Norio ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b Kinki Central Hospital of Mutual Association of Public School Teachers   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ACROMEGALY; ADULT; AGED; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ACROMEGALY; ADENOMA; ADULT; AGED; CASE-CONTROL STUDIES; COMPUTER SIMULATION; DIABETES MELLITUS; FEMALE; GLUCOSE INTOLERANCE; GROWTH HORMONE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PITUITARY NEOPLASMS;

EID: 0034037529     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00986.x     Document Type: Article

References (25)

1. Bolinder, J., Ostman, J., Werner, S. & Arner, P. (1986) Insulin action in human adipose tissue in acromegaly. Journal of Clinical Investigation, 77, 1201-1206.
2. Cantalamessa, L., Catania, A., Baldini, M. & Orsatti, A. (1986) Improvement of diabetes after treatment with somatostatin analogue SMS 201-995 in an acromegalic patient. Hormone and Metabolic Research, 18, 790-791.
3. Di Cola, G., Cool, M.H. & Accilli, D. (1997) Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. Journal of Clinical Investigation, 99, 2538-2544.
4. Fineberg, S.E., Merinee, T.J., Rabinowitz, D. & Edgar, P.J. (1970) Insulin secretion in acromegaly. Journal of Clinical Endocrinology and Metabolism, 30, 288-292.
5. Foss, M.C., Saad, M.J.A., Paccola, G.M.G.F., Paula, F.J.A., Piccinato, C.E. & Moreira, A.C. (1991) Peripheral glucose metabolism in acromegaly. Journal of Clinical Endocrinology and Metabolism, 72, 1048-1053.
6. Galbraith, H.J.B., Ginsburg, J. & Paton, A. (1960) Decreased response to intraarterial insulin in acromegaly. Diabetes, 9, 459-465.
7. Hansen, I., Tsalikian, E., Beaufrere, B., Gerich, J., Haymond, M. & Rizza, R. (1986) Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. American Journal of Physiology, 250, E269-E273.
8. Hirose, T., Kuroda, T., Otsuki, M., Takagi, M., Yamamoto, H., Motomura, T., Kurebayashi, S., Miyashita, Y., Koga, M., Arita, N., Hayakawa, T., Kishimoto, T. & Kasayama, S. (1997) A case with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide. Internal Medicine, 36, 345-350.
9. Ho, K.K.Y., Jenkins, A.B., Furler, S.M., Borkman, M. & Chisholm, D.J. (1992) Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. Clinical Endocrinology, 36, 271-279.
10. Jadresic, A., Banks, L.M., Child, D.F., Diamant, L., Doyle, F.H., Fraser, T.R. & Joplin, G.F. (1982) The acromegaly syndrome. Quarterly Journal of Medicine, 51, 189-204.
11. Kahn, C.R. & Catanese, V.M. (1990) Secondary forms of diabetes mellitus. In Principles and Practice of Endocrinology and Metabolism (ed. by K.L. Becker), pp. 1087-1093. J.B. Lippincott, Philadelphia.
12. Karlander, S., Vranic, M. & Efendic, S. (1986) Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance. Diabetologia, 29, 778-783.
13. Lamberts, S.W.J., Uitterlinden, P., Schuijff, P.C. & Klijn, J.G.M. (1988) Therapy of acromegaly with Sandostatin: the predictive value of an acute test, the value of serum somatomedin-C measurements in dose adjustment and the definition of biochemic 'cure'. Clinical Endocrinology, 29, 411-420.
14. Levy, J., Manley, S., Sutton, P. & Camps, I. (1995) Beta-cell function assessed by the hyperglycemic clamp: reproducibility compared with HOMA analysis from fasting values, and factors influencing variability. Diabetes, 44 (suppl. 1), 89A.
15. Levy, J.C., Matthews, D.R. & Hermans, M.P. (1998) Correct homestasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care, 21, 2191-2192.
16. Luft, R., Cerasi, E. & Hamberger, C.A. (1967) Studies on the pathogenesis of diabetes in acromegaly. Acta Endocrinologica, 56, 593-607.
17. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. & Turner, R.C. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
18. Melmed, S., Ho, K., Klibanski, A., Reichlin, S. & Thorner, M. (1995) Recent advances in pathogenesis, diagnosis, and management of acromegaly. Journal of Clinical Endocrinology and Metabolism, 80, 3395-3402.
19. Møller, N., Schmitz, O., Jørgensen, J.O.L., Astrup, J., Bak, J.F., Christensen, S.E., Alberti, K.G.M.M. & Weeke, J. (1992) Basal-and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. Journal of Clinical Endocrinology and Metabolism, 74, 1012-1019.
20. Nabarro, J.D.N. (1987) Acromegaly. Clinical Endocrinology, 26, 481-512.
21. Roelfsema, F. & Frölich, M. (1985) Glucose tolerance and plasma immunoreactive insulin levels in acromegalics and after selective transsphenoidal surgery. Clinical Endocrinology, 22, 531-537.
22. Sonenberg, M., Free, C.A., Dellacha, J.M., Bonadonna, G., Haymowitz, A. & Nadler, A.C. (1965) The metabolic effects in man of bovine growth hormone digested with trypsin. Metabolism, 14, 1189-1213.
23. Sönksen, P.H., Greenwood, F.C., Ellis, J.P., Lowy, C., Rutherford, A. & Nabarro, J.D.N. (1967) Changes in carbohydrate tolerance in acromegaly with progress of the disease and in response to treatment. Journal of Clinical Endocrinology and Metabolism, 27, 1418-1430.
24. Swislocki, N.L. (1968) Effects of nutritional status and the pituitary on the acute plasma free fatty acid and glucose responses of rats to growth hormone administration. Metabolism, 17, 174-180.
25. Wasada, T., Aoki, K., Sato, A., Katsumori, K., Muto, K., Tomonaga, O., Yokoyama, H., Iwasaki, N., Babazono, T., Takahashi, C., Iwamoto, Y., Omori, Y. & Hizuka, N. (1997) Assessment of insulin resistance in acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. Endocrine Journal, 44, 617-620.