Enhanced urinary excretion of cysteinyl leukotrienes in patients with acute alcohol intoxication

Gastroenterology

Volumn 118, Issue 6, 2000, Pages 1140-1148

  Uemura, Masahito ^a,d   Lehmann, Wolf dieter ^a   Schneider, Winfried ^b   Seitz, Helmut K ^b   Benner, Axel ^a   Keppler Hafkemeyer, Andrea ^c   Hafkemeyer, Peter ^c   Kojima, Hideyuki ^d   Fujimoto, Masao ^d   Tsujii, Tadasu ^d   Fukui, Hiroshi ^d   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Krankenhaus Salem   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYLEUKOTRIENE B4; LEUKOTRIENE; LEUKOTRIENE B4; LEUKOTRIENE E4; LEUKOTRIENE E4 DERIVATIVE;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTOXEMIA; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOPATHOGENESIS; LIVER CELL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RADIOIMMUNOASSAY; URINARY EXCRETION;

EID: 0034036290     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(00)70367-2     Document Type: Article

References (45)

1. WC. Maddrey Alcoholic hepatitis: pathogenesis and approaches to treatment Scand J Gastroenterol 25 suppl 175 1990 118 130
2. CS. Lieber Biochemical and molecular basis of alcohol-induced injury to liver and other tissues N Engl J Med 319 1988 1639 1650
3. B Samuelsson SE Dahlén JA Lindgren CA Rouzer CN. Serhan Leukotrienes and lipoxins: structures, biosynthesis, and biological effects Science 237 1987 1171 1176
4. RA Lewis KF Austen RJ. Soberman Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases N Engl J Med 323 1990 645 655
5. 4 in inflammation Immunology 10 1990 1 12
6. D Keppler W Hagmann S Rapp C Denzlinger HK. Koch The relation of leukotrienes to liver injury Hepatology 5 1985 883 891
7. M Wettstein B Noe D. Häussinger Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state Hepatology 22 1995 235 240
8. W Hagmann AM Steffan A Kirn D. Keppler Leukotriene as mediators in frog virus 3–induced hepatitis in rats Hepatology 7 1987 732 736
9. 4 metabolites produced by hepatocytes in the presence of ethanol Biochem Biophys Res Commun 185 1992 604 610
10. C Denzlinger S Rapp W Hagmann D. Keppler Leukotrienes as mediators in tissue trauma Science 230 1985 330 332
11. C Denzlinger A Guhlmann PH Scheuber D Wilker DK Hammer D. Keppler Metabolism and analysis of cysteinyl leukotrienes in the monkey J Biol Chem 261 1986 15601 15606
12. 3 in the mouse J Biol Chem 257 1982 531 535
13. 4 in rats Biochem J 267 1990 467 470
14. 4 metabolite J Biol Chem 265 1990 16288 16295
15. I Leier M Müller G Jedlitschky D. Keppler Leukotriene uptake by hepatocytes and hepatoma cells Eur J Biochem 209 1992 281 289
16. 4 Eur J Biochem 170 1987 77 85
17. 4 by rat liver cytosol Biochim Biophys Acta 960 1988 342 350
18. G Jedlitschky M Huber A Völkl M Müller I Leier J Müller WD Lehmann HD Fahimi D. Keppler Peroxisomal degradation of leukotrienes by ω-oxidation from the β-end J Biol Chem 25 1991 24763 24772
19. T Baumert M Huber D Mayer D. Keppler Ethanol-induced inhibition of leukotriene degradation by ω-oxidation Eur J Bio-chem 182 1989 223 229
20. 4 J Biol Chem 263 1984 7966 8002
21. 4 in isolated rat hepatocytes J Pharmacol Exp Ther 285 1998 155 161
22. HD Perez FJ Roll DM Bissell S Shak IM. Goldstein Production of chemotactic activity for polymorphonuclear leukocytes by cultured rat hepatocytes exposed to ethanol J Clin Invest 74 1984 1350 1357
23. M Huber S Kästner J Scholmerich W Gerok D. Keppler Analysis of cysteinyl leukotrienes in human urine: enhanced excretion in patients with liver cirrhosis and hepatorenal syndrome Eur J Clin Invest 19 1989 53 60
24. 4 after antigen challenge and in acute asthma and allergic rhinitis Lancet 1 1989 584 588
25. E Mayatepek WD Lehmann J Fauler D Tsikas JC Frölich RB Schutgens RJ Wanders D. Keppler Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders J Clin Invest 91 1993 881 888
26. M Uemura U Buchholz H Kojima A Keppler P Hafkemeyer H Fukui T Tsujii D. Keppler Cysteinyl leukotrienes in the urine of patients with liver diseases Hepatology 20 1994 804 812
27. M Huber J Müller I Leier G Jedlitschky HA Ball KP Moore GW Taylor R Williams D. Keppler Metabolism of cysteinyl leukotrienes in monkey and man Eur J Biochem 194 1990 309 315
28. 4 elimination and metabolism in normal human subjects J Biol Chem 265 1990 21771 21778
29. 4 elimination and metabolism in man J Allergy Clin Immunol 85 1990 3 9
30. 4 and of four of their novel ω- and β-oxidative metabolites in air ways of guinea-pig and man in vitro Br J Pharmacol 98 1989 1406 1412
31. 4 in the monkey. Identification of the principal nonvolatile metabolism in the urine Prostaglandins 27 1984 899 911
32. 4 in patients with Zellweger syndrome Clin Chim Acta 282 1999 151 155
33. A Guhlmann K Krauss F Oberdorfer T Siegel PH Scheuber J Müller B Csuk-Glänzer S Ziegler H Ostertag D. Keppler Noninvasive assessment of hepatobiliary and renal elimination of cysteinyl leukotrienes by positron emission tomography Hepatology 21 1995 1568 1575
34. M. Kumlin Measurement of leukotrienes in the urine: strategies and applications Allergy 52 1997 124 135
35. S O'Sullivan A Roquet B Dahlén SE Dahlén M. Kumlin Urinary excretion of inflammatory mediators during allergen-induced early and late phase asthmatic reactions Clin Exp Allergy 28 1998 1332 1339
36. M Balazy RC. Murphy Determination of sulfidopeptide leukotrienes in biological fluids by gas chromatography/mass spectrometry Anal Chem 58 1986 1098 1101
37. TW. Rall Hypnotics and sedatives: ethanol 8th ed A Goodman Gilman TW Rall AS Nies P Taylaar The pharmacological basis of therapeutics 1993 Macmillan-Hill New York 345 382
38. M Huber B Beutler D. Keppler Tumor necrosis factor-α stimulates leukotriene production in vivo Eur J Immunol 18 1988 2085 2088
39. C Bode V Kugler JC. Bode Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess J Hepatol 4 1987 8 14
40. W Hagmann C Denzlinger D. Keppler Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action Circ Shock 14 1984 223 235
41. M Huber D. Keppler Eicosanoids and the liver H Popper F Schaffner Progress in liver diseases Volume 9 1990 Saunders Philadelphia 117 141
42. B Beutler A. Cerami Cachectin: more than a tumor necrosis factor N Engl J Med 316 1987 379 385
43. CJ McClain DA. Cohen Increased tumor necrosis factor production by monocytes in alcoholic hepatitis Hepatology 9 1989 349 351
44. 4: a metabolite from ethanol-treated rat hepatocytes J Pharmacol Exp Ther 271 1994 1514 1519
45. 4 in human polymorphonuclear leukocytes J Biol Chem 259 1984 10181 10187