Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis

Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2000, Pages 1692-1698

  Wielert Badt, Susanne ^b   Lin, Jiann Trzuo ^b   Lorenz, Mike ^b   Fritz, Stefan ^a,b   Kinne, Rolf K H ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHLORIZIN;

ARTICLE; CHEMICAL ANALYSIS; COMPUTER MODEL; DRUG CONFORMATION; HYDROGEN BOND; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PHARMACOPHORE; STRUCTURE ANALYSIS;

COMPUTER-AIDED DESIGN; CRYSTALLIZATION; HYDROGEN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONOSACCHARIDE TRANSPORT PROTEINS; PHLORHIZIN; PROTONS;

EID: 0034035556     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9905460     Document Type: Article

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