The effects of inhalation of nebulized nitroglycerin on dogs with experimental pulmonary hypertension induced by U46619

Chinese Medical Journal

Volumn 113, Issue 5, 2000, Pages 475-476

  Gong, Fangqi ^a   Shiraishi, Hirohiko ^b   Momoi, Manko Y ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; GLYCERYL TRINITRATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; NEBULIZATION; NONHUMAN; PULMONARY HYPERTENSION; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADMINISTRATION, INHALATION; ANIMALS; DOGS; HYPERTENSION, PULMONARY; NEBULIZERS AND VAPORIZERS; NITROGLYCERIN; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0034035292     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. van Obbergh LJ, Charbonneau M, Blaise G. Combination of inhaled nitric oxide with i.v. nitroglycerin or with a prostacyclin analogue in the treatment of experimental pulmonary hypertension. Br J Anaesth 1996;77:227-231.
2. Troncy E, Jacob E, da Silva P, et al. Comparison of the effect of inhaled nitric oxide and intravenous nitroglycerin on hypoxia-induced pulmonary hypertension in pigs. Eur J Anaesthesiol 1996;13:521-529.
3. Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218: 739-749.
4. Feelisch M. The biochemical pathways of nitric oxide formation from nitrovasodilators: appropriate choice of exogenous NO donors and aspect of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol 1991;17 (Suppl 3):S25-S33.
5. Chung SJ, Fung HL. Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells. J Pharmacol Exp Ther 1990;253:614-619.
6. Salvemini D, Pistelli A, Vane J. Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. Br J Pharmacol 1993;108:162-169.