Aprotinin in the management of life-threatening bleeding during extracorporeal life support

Perfusion

Volumn 15, Issue 3, 2000, Pages 211-216

  Biswas, Abhik K ^a,b   Lewis, Leslie ^a   Sommerauer, John F ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NAVAL MEDICAL CENTER PORTSMOUTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; HEPARIN;

ADOLESCENT; ADULT; ARTICLE; BLEEDING; BLOOD COMPONENT THERAPY; CARDIOPULMONARY BYPASS; CHILD; CLINICAL ARTICLE; DRUG INFUSION; EPISTAXIS; EXTRACORPOREAL CIRCULATION; FEMALE; HUMAN; INTEGRATED CIRCUIT; INTRAOPERATIVE PERIOD; LONG TERM CARE; MALE; NEWBORN; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL;

EID: 0034033832     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1177/026765910001500305     Document Type: Article

References (14)

1. Westaby S. Aprotinin in perspective. Ann Thorac Surg 1993; 55: 1033-41.
2. Wildevuur C, Eijsman L, Roozendaal K et al. Platelet preservation during cardiopulmonary bypass with aprotinin. Eur J Cardio-thorac Surg 1989; 3: 533-38.
3. Shigeta O, Kojima H, Jikuya T et al. Aprotinin inhibits plasmin-induced platelet activation during cardiopulmonary bypass. Circulation 1997; 96: 569-74.
4. van Oeveren W, Harder M, Roozendaal K, et al. Aprotinin protects platelets against the initial effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990; 99: 788-97.
5. Huang H, Ding W, Su Z, Zhang W. Mechanism of the preserving effect of aprotinin on platelet function and its use in cardiac surgery. J Thorac Cardiovasc Surg 1993; 106: 11-18.
6. van Oeveren W, Eijsman L, Roozendaal K et al. Platelet preservation by aprotinin during cardiopulmonary bypass. Lancet 1988; 11: 644.
7. Boldt J, Knothe C, Zickmann B et al. Comparison of two aprotinin dosage regimens in pediatric patients having cardiac operations. J Thorac Cardiovasc Surg 1993; 105: 705-11.
8. Davies M, Allen A, Kort H et al. Prospective, randomized, double-blind study of high-dose aprotinin in pediatric cardiac operations. Ann Thorac Surg, 1997; 63: 497-503.
9. Jaquiss R, Huddleston C, Spray T. Use of aprotinin in pediatric lung transplantation. J Heart Lung Transplant 1995; 14: 302-7.
10. Boldt J, Knothe C, Zickmann B et al. Aprotinin in pediatric cardiac operations: platelet function, blood loss, and use of homologous blood. Ann Thorac Surg 1993; 55: 1460-66.
11. Plotz F, van Oeveren W, Bartlett R et al. Blood activation during neonatal extracorporeal life support. J Thorac Cardiovasc Surg 1993; 105: 823-32.
12. Wachtfogel Y, Kucich U, Hack C et al. Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion. J Thorac Cardiovasc Surg 1993; 106: 1-10.
13. 2 removal. Int Care Med 1992; 18: 364-67.
14. Mössinger H, Dietrich W. Activation of hemostasis during cardiopulmonary bypass and pediatric aprotinin dosage. Ann Thorac Surg 1998; 65: S45-51.