Antithrombotic activity of NSP-513, a novel selective phosphodiesterase 3 inhibitor, on femoral arterial thrombosis induced by physical stenosis and electrical current: Comparison of antithrombotic and hemodynamic effects

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 4, 2000, Pages 586-594

  Hirose, Hiroyasu ^a   Mashiko, Satoshi ^a   Kimura, Toshifumi ^a   Ishida, Fumiaki ^a   Mochizuki, Nobuo ^b   Nishibe, Tadayuki ^b   Nishikibe, Masaru ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b NIPPON SODA CO LTD   (Japan)

Author keywords

Arterial thrombosis; Dog; NSP 513; Phosphodiesterase 3

Indexed keywords

4,5 DIHYDRO 5 METHYL 6 [4 (2 PROPYL 3 OXO 1 CYCLOHEXENYL)AMINO]PHENYL 3(2H) PYRIDAZINONE; 4,5 DIHYDRO 5 METHYL 6 [4 (3 OXO 2 PROPYL 1 CYCLOHEXENYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; ADENOSINE DIPHOSPHATE; CILOSTAZOL; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PROSTAGLANDIN E1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERY OCCLUSION; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOG; DRUG EFFICACY; FEMORAL ARTERY; HEART RATE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DOGS; ELECTRICITY; FEMORAL ARTERY; FIBRINOLYTIC AGENTS; HEMODYNAMIC PROCESSES; PHOSPHODIESTERASE INHIBITORS; PLATELET AGGREGATION INHIBITORS; PYRIDAZINES; THROMBOSIS;

EID: 0034033824     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200004000-00012     Document Type: Article

References (4)

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3. Nicholson CD, Challiss RAJ, Shahid M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 1991;12:19-27.
4. Tani T, Sakurai K, Kimura Y, Ishikawa T, Hidaka H. Pharmacological manipulation of tissue cyclic AMP by inhibitors: effects of phosphodiesterase inhibitors on the functions of platelets and vascular endothelial cells. Adv Second Messenger Phosphoprot Res 1992;25:215-27.