Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies

Hormone and Metabolic Research

Volumn 32, Issue 4, 2000, Pages 133-138

  Schranz, D B ^a   Bekris, L ^a   Landin Olsson, M ^b   Torn C ^b   Nilang A ^a   Toll, A ^a   Sjostrom J ^a   Gronland H ^c   Lernmark, Åke ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c Thermo Fisher Scientific   (United States)

Author keywords

Autoimmunity; Diabetes Mellitus; Islet Cell Autoantibodies; ROC Curve; Type I Diabetes; Type II Diabetes

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; DISEASE MARKER; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0034030240     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978607     Document Type: Article

References (36)

1. 1 Arnqvist HJ, Littorin B, Nystrom L, Scherstên B, Ostman J, Blohmé G, Lithner F, Wibell L. Difficulties in classifying diabetes at presentation in the young adult. Diabetic Med 1993; 10: 606-613
2. 2 Bonifacio E, Lernmark Å, Dawkins RL. Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies. J Immunol Methods 1988; 106: 83-88
3. 3H recombinant human ligands. J Immunol Methods 1995; 186: 89-99
4. 4 Gottsäter A, Landin-Olsson M, Fernlund P, Lernmark Å, Sundkvist G. β-cell function in relation to islet cell antibodies (ICA) during the first three years after the clinical diagnosis of diabetes in non-insulin-dependent (type II) diabetic patients. Diabetes Care 1993; 16: 902-910
5. 5 Gottsäter A, Landin-Olsson M, Lernmark Å, Fernlund P, Sundkvist G, Hagopian WA. Glutamate decarboxylase antibody levels predict rate of beta-cell decline in adult onset diabetes. Diab Res Clin Pract 1995; 27: 133-140
6. 6 Greenbaum CJ, Palmer JP, Nagataki S, Yamaguchi Y, Molenaar JL, van Beers WAM, Maclaren NK, Lernmark Å. Improved specificity of ICA assays in Fourth International Immunology of Diabetes Serum Exchange Workshop. Diabetes 1992; 41: 1570-1574
7. 7 Groop LC, Bottazzo GF, Doniac D. Islet cell antibodies identify latent type 1 diabetes in patients aged 35-75 years at diagnosis. Diabetes 1986; 35: 237-241
8. 8 Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lernmark Å. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344-350
9. 9 Hagopian WA, Karlsen AE, Gottsäter A, Landin-Olsson M, Grubin CE, Sundkvist G, Petersen JS, Boel E, Dyrberg T, Lernmark Å. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody positivity at onset predicts diabetes type. J Clin Invest 1993; 91: 368-374
10. 10 Humphrey ARC, McCarty DJ, Mackay IR, Rowley MJ, Dwyer T, Zimmet P. Autoantibodies to glutamic acid decarboxylase and phenotypic features associated with early insulin treatment in individuals with adult-onset diabetes mellitus. Diabetic Medicine 1998; 15: 113-119
11. 11 Kobayashi T, Tamemoto K, Nakanishi K, Kato N, Okubo M, Kajio H, Sugimoto T, Murase T, Kosaka K. Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care 1993; 16: 780-788
12. 12 Lampasona V, Bearzatto M, Genovese S, Bosi E, Ferrari M, Bonifacio E. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like 1A-2 autoantigen. J Immunol 1996; 157: 2707-2711
13. 13 Landin-Olsson M, Arnqvist HJ, Blohme G, Littorin B, Lithner F, Nystrom L, Schersten B, Sundkvist G, Wibell L, Ostman J, Lernmark Å. Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus. Autoimmunity 1999; 29: 57-63
14. 14 Landin-Olsson M, Karlsson FA, Lernmark Å, Sundkvist G. Islet cell and thyrogastric antibodies in 633 consecutive 15-34 years old patients in the Diabetes Incidence Study in Sweden (DISS). Diabetes 1992; 41: 1022-1027
15. 15 Landin-Olsson M, Nilsson KO, Lernmark Å, Sundkvist G. Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia 1990; 33: 561-568
16. 16 Littorin B, Sundkvist G, Hagopian W, Landin-Olsson M, Lernmark Å, O̊stman J, Arnqvist HJ, Blohmé G, Bolinder J, Eriksson JW, Lithner F, Scherstén B, Wibell L. Antibodies (ICA and GADA) at diagnosis of diabetes predict the subsequent need for insulin. Diabetes Care 1999; 22: 409-412
17. 17 Niskanen L, Karjalainen J, Sarlund H, Siitonen O, Uusitupa M. Five-year follow-up of islet cell antibodies in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991; 34: 402-408
18. 18 Niskanen LK, Tuomi T, Karjalainen J, Groop LC, Uusitupa MI. GAD antibodies in NIDDM. Ten-year-follow-up from the diagnosis. Diabetes Care 1995; 18: 1557-1565
19. 19 Nyström L, Dahlquist G, Östman J, Wall S, Arnqvist H, Blohmé G, Lithner F, Littorin B, Schersten B, Wibell L Risk of developing insulin-dependent diabetes mellitus (IDDM) before 35 years of age: Indications of dimatological determinants for age at onset. Int J Epidemiology 1992; 21: 352-358
20. 20 Östman J, Arnqvist H, Blohmé G, Lithner F, Littorin B. Nyström L, Sandström A, Scherstén B, Wall S, Wibell L. Epidemiology of diabetes mellitus in Sweden. Results of the first year of a prospective study in the population age group 15-34 years. Acta Med Scand 1986; 220: 437-445
21. 21 Payton MA, Hawkes CJ, Christie MR. Relationship of the 37,000-and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 1995; 96: 1506-1511
22. 22 Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen BK, Dyrberg T. Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 1994; 43: 459-465
23. 23 Schmidli RS, Colman PC, Bonifacio E. Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second International GADAB Workshop. Diabetes 1995; 44: 636-640
24. 24 Schmidli RS, Colman PG, Bonifacio E, Bottazzo GF, Harrison LC. High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes 1994; 43: 1005-1009
25. 25 Schranz DB, Bekris L, Landin O-M, Torn C, Nilang A, Toll A, Gronlund H, Toivola B, Lernmark Å. A simple and rapid microSepharose assay for GAD65 and ICA512 autoantibodies in diabetes. J Immunol Methods 1998; 213: 87-97
26. 26 Seissler J, deSonnaville JJJ, Morgenthaler NG, Steinbrenner H, Glawe D, KhooMorgenthaler UY, Lan MS, Notkins AL, Heine RJ, Scherbaum WA. Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease. Diabetologia 1998; 41: 891-897
27. 27 Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993; 42: 359-362
28. 28 Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and 1CA512bdc/1A-2 autoantibodies. Diabetes 1996; 45: 926-933
29. 29 Verge CF, Stenger D, Bonifacio E, Colman PC, Pilcher C, Bingley PJ, Eisenbarth GS. Combined use of autoantibodies (IA-2) autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. Diabetes 1998; 47: 1857-1866
30. 30 Wagener DK, Kuller LH, Orchard TJ, LaPorte RE, Rabin B, Drash AL. Pittsburgh diabetes mellitus study. II. Secondary attack rates in families with insulin-dependent diabetes mellitus. Am J Epidemiol 1982; 115: 868-878
31. 31 Wasmeier C, Hutton JC. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 1996; 271: 18161-18170
32. 32 WHO Study Group. Diabetes mellitus. WHO Technical Report Series 1985: 1-727
33. 33 Willis JA, Scott RS, Brown LJ, Forbes LV, Schmidli RS, Zimmet PZ, MacKay IR, Rowley MJ. Islet cell antibodies and antibodies against glutamic acid decarboxylase in newly diagnosed adult-onset diabetes mellitus. Diabetes Res Clin Practice 1996; 33: 89-97
34. 34 Wilson RM, Van der Minne P, Deverill I, Heller SR, Gelsthorpe K, Reeves WG, Tattersall RB. Insulin dependence: Problems with the classification of 100 consecutive patients. Diabetic Med 1985; 2: 167-172
35. 35 Zimmet PZ, Tuomi T, Mackay IR, Rowley MJ, Knowles W, Cohen M, Lang DA. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabetic Med 1994; 11: 299-303
36. 36 Zweig M, Campbell G. Receiver-operating characteristics (ROC) plots: a fundamental tool in clinical medicine. Clin Chem 1993; 39: 561-577