Effect of lamivudine on uptake of organic cations by rat renal brush-border and basolateral membrane vesicles

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 5, 2000, Pages 569-575

  Takubo, Takatoshi ^a   Kato, Toshihiro ^a   Kinami, Junji ^a   Hanada, Kazuhiko ^b   Ogata, Hiroyasu ^b  

^a Tsukuba Research Laboratories   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; LAMIVUDINE; PROBENECID; TETRYLAMMONIUM; TRIMETHOPRIM;

ANIMAL TISSUE; ARTICLE; BRUSH BORDER VESICLE; CATION TRANSPORT; CONCENTRATION RESPONSE; DRUG EXCRETION; DRUG METABOLISM; INHIBITION KINETICS; KIDNEY CLEARANCE; KIDNEY PARENCHYMA; KIDNEY TUBULE EXCRETION; MALE; MEMBRANE VESICLE; NONHUMAN; RAT;

EID: 0034029775     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774219     Document Type: Article

References (28)

1. Aiba, T., Sakurai, Y., Tsukada, S., Koizumi, T. (1995) Effect of probenecid and cimetidine on the renal excretion of 3′-azido-3′-deoxythymidine in rats. J. Pharmacol. Exp. Ther. 272: 94-99
2. Bendayan, R. (1996) Renal drug transport: a review. Pharmacotherapy 16: 971-985
3. Bonate, P. L., Reith, K., Weir, S. (1998) Drug interactions at the renal level. Implication for drug development. Clin. Pharmacokinet. 34: 375-404
4. Cacini, W. (1987) In vivo renal tubular secretion of trimethoprim without metabolism. Biochem. Pharmacol. 36: 2693-2695
5. Chang, C., Zhou, J. H., Beach, J. W., Jeong, L. S., Chu, C. K., Tsai, C., Cheng, Y. (1992) Deoxycytidine deaminase-resistant stereoisomer is the active form of (±)-2′-3′-dideoxy-3′-thiacytidine in the inhibition of hepatitis B virus replication. J. Biol. Chem. 267: 13938-13942
6. Coates, J. A. V., Cammack, N., Jenkinson, H. J., Jowett, A. J., Jowett, M. I., Pearson, B. A., Penn, C. R., Rouse, P. L., Viner, K. C., Cameron, J. M. (1992) (-)-2′-Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro. Antimicrob. Agents Chemother. 36: 733-739
7. +/organic cations in the rat proximal tubule. Pflügers Arch. 430: 477-492
8. Doong, S., Tsai, C., Schinazi, R. F., Liotta, D. C., Cheng, Y. (1991) Inhibition of the replication of hepatitis B virus in vitro by 2′,3′-dideoxy-3′-thiacytidine and related analogues. Proc. Natl Acad. Sci. USA 88: 8495-8499
9. Evers, C., Hasse, W., Murer, H., Kinne, R. (1978) Properties of brush border vesicles isolated from rat kidney cortex by calcium precipitation. Membr. Biochem. 1: 203-219
10. Griffiths, D. A., Hall, S. D., Sokol, P. P. (1991) Interaction of 3′-azido-3′-deoxythymidine (AZT) with organic ion transport in rat renal basolateral membrane vesicles. J. Pharmacol. Exp. Ther. 257: 149-155
11. Griffiths, D. A., Hall, S. D., Sokol, P. P. (1992) Effect of 3′-azido-3′-deoxythymidine (AZT) on organic ion transport in rat renal brush-border membrane vesicles. J. Pharmacol. Exp. Ther. 260: 128-133
12. Hart, G. J., Orr, D. C., Penn, C. R., Figueiredo, H. T., Gray, N. M., Boehme, R. E., Cameron, J. M. (1992) Effects of (-)-2′-deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerase alpha, beta, and gamma. Antimicrob. Agents Chemother. 36: 1688-1694
13. Johnson, M. A., Moore, K. H. P., Yuen, G. J., Rye, A., Pakes, G. E. (1999) Clinical pharmacokinetics of lamivudine. Clin. Pharmacokinet. 36: 41-66
14. +)-ATPase. Methods Enzymol. 32: 277-290
15. Katsura, T., Takano, M., Tomita, Y., Yasuhara, M., Inui, K., Hori, R. (1993) Characteristics of organic cation transporter in rat renal basolateral membrane. Biochim. Biophys. Acta 1146: 197-202
16. +/organic cation antiport system in rat renal brush-border membranes. J. Biol. Chem. 263: 11150-11154
17. Moore, K. H., Yuen, G. J., Raasch, R. H., Eron, J. J., Martin, D., Mydlow, P. K., Hussy, E. K. (1996) Pharmacokinetics of lamivudine administration alone and with trimethoprim-sulfamethoxazole. Clin. Pharmacol. Ther. 59: 550-558
18. Murer, H., Gmaj, P. (1986) Transport studies in plasma membrane vesicles isolated from renal cortex. Kidney Int. 30: 171-186
19. Pritchard, J. B., Miller, D. S. (1997) Renal secretion of organic cations: a multislep process. Adv. Drug Deliv. Rev. 25: 231-242
20. 2-receptor antagonists on tetraethyl-ammonium uptake in rat renal brush-border membrane vesicles. J. Pharm. Pharmacol. 46: 375-377
21. Sweeney, K. R., Hsyu, P., Statkevich. P., Taft, D. R. (1995) Renal disposition and drug interaction screening of (-)-2′-deoxy-3′-thiacytidine (3TC) in the isolated perfused rat kidney. Pharm. Res. 12: 1958-1963
22. Takano, M., Inui, K., Okano, T., Saito, H., Hori, R. (1984) Carrier-mediated transport systems of tetraethylammonium in rat renal brush border and basolateral membrane vesicles. Biochim. Biophys. Acta 773: 113-124
23. Takano, M., Inui, K., Okano, T., Hori, R. (1985) Cimetidine transport in rat renal brush border and basolateral membrane vesicles. Life Sci. 37: 1579-1585
24. Takubo, T., Moriya, T., Hirayama, S., Minamide, Y., Kato, T., Nakamura, R., Kinami, J. (1997) Studies on the metabolic fate of lamivudine (I). Xenobio. Metab. Dispos. 12: 85-91
25. Tsuno-o, M., Saihara, S., Kinami, J., Ichikawa, Y., Takeuchi, Y., Mambo, K., Namba, J. (1997) Phase I study of GG714 (lamivudine) - evaluation of safety and pharmacokinetics of single and multiple dose administration. J. Clin. Ther. Med. 13: 1459-1482
26. 1-methylnicotinamide across brush-border membrane vesicles from rabbit kidney. Am. J. Physiol. 249: F903-F911
27. Wright, S. H. (1996) Characterization of renal brush border and basolateral membrane transporters for organic cations. Cellular Physiol. Biochem. 6: 112-122
28. + exchanger of the renal luminal membrane. Pflügers Arch 436: 469-477