Effect of nucleoside analogue therapy on duck hepatitis B viral replication in hepatocytes and bile duct epithelial cells in vivo

Journal of Gastroenterology and Hepatology (Australia)

Volumn 15, Issue 3, 2000, Pages 304-310

  Nicoll, Amanda ^a   Locarnini, Stephen ^a   Chou, Sheung To ^b   Smallwood, Richard ^b   Angus, Peter ^b  

^a VICTORIAN INFECTIOUS DISEASES REFERENCE LABORATORY   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Bile duct epithelial cells; Hepatitis B virus; Nucleoside analogue; Pekin duck model

Indexed keywords

NUCLEOSIDE ANALOG; PENCICLOVIR; VIRUS ANTIGEN; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BILE DUCT; CONTROLLED STUDY; DRUG EFFECT; DUCK; EPITHELIUM CELL; HEPATITIS B VIRUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CELL; LIVER HISTOLOGY; LIVER TRANSPLANTATION; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REINFECTION; VIREMIA; VIRUS REPLICATION;

EID: 0034027166     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2000.02079.x     Document Type: Article

References (41)

1. Davies SE, Portmann BC, O'Grady JG et al. Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. Hepatology 1991; 13: 150-7.
2. Benner KG, Lee RG, Keefe EB, Lopez RR, Sasaki AW, Pinson CW. Fibrosing cytolytic liver failure secondary to recurrent hepatitis B after liver transplantation. Gastroenterology 1992; 103: 1307-12.
3. O'Grady JG, Smith HM, Davies SE et al. Hepatitis B virus reinfection after orthotopic liver transplantation. J. Hepatol. 1992; 14: 104-11.
4. Lau JYN, Bain VG, Davies SE et al. High level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis. Gastroenterology 1992; 102: 956-62.
5. Mason A, Wick M, White H, Perrillo R. Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection. Hepatology 1993; 18: 781-9.
6. Lau JYN, Bain VG, Davies SE, Alexander GJM, Williams R. Export of intracellular HBsAg in chronic hepatitis B virus infection is related to viral replication. Hepatology 1991; 14: 416-21.
7. Samuel D, Muller R, Alexander G, Fassati L, Ducot B, Benhamou J et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl. J. Med. 1993; 329: 1842-7.
8. Shaw T, Locarnini S. Hepatic purine and pyrimidine metabolism: Implications for antiviral chemotherapy of viral hepatitis. Liver 1995; 15: 169-84.
9. Angus PW, Richards M, Bowden S et al. Combination antiviral therapy controls severe post liver transplant recurrence of hepatitis B virus infection. J. Gastroenterol. Hepatol. 1993; 8: 353-7.
10. Lai CL, Ching CK,Tung A et al. Short term lamivudine suppresses HBV-DNA in Chinese HBsAg carriers. Hepatology 1994; 20: 298A.
11. Dienstag JL, Perrillo RP, Schiff ER, Bartholomew M, Vicary C, Rubin M. A preliminary trial of lamivudine for chronic hepatitis B infection. N. Engl. J. Med. 1995; 333: 1657-61.
12. McKenzie R, Fried MW, Sallie R et al. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. N. Engl. J. Med. 1995; 333: 1099-105.
13. Marshall E. Drug trial deaths deemed unavoidable. Science 1994; 264: 1530.
14. Ling R, Mutimer D, Ahmed M, Boxall E, Elias E, Dusheiko G. Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 1996; 24: 711-13.
15. Aye T, Bartholomeusz A, Shaw T et al. Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. J. Hepatol. 1997; 26: 1148-53.
16. Luscombe CA, Pederson J, Bowden S, Locarnini S. Alterations in intrahepatic expression of duck hepatitis B viral markers with ganciclovir chemotherapy. Liver 1994; 14: 182-92.
17. Lin E, Luscombe C, Wang YY. Shaw T, Locarnini S. The guanine nucleoside analog penciclovir is active against chronic duck hepatitis B virus infection in vivo. Antimicrob. Agents Chemother. 1996; 40: 413-18.
18. Luscombe C, Pedersen J, Uren E, Locarnini S. Long term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: Effect on intrahepatitic viral DNA, RNA and protein expression. Hepatology 1996; 24: 766-73.
19. Honkoop P, de Man R, Heijtink R, Schalm S. Hepatitis B reactivation after lamivudine. Lancet 1995; 346: 1156-7.
20. Main J, Brown J, Howells C et al. A double blind, placebocontrolled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. J. Viral Hepatitis 1996; 3:211-15.
21. Kruger M, Tillmann HL, Trautwein C et al. Treatment of hepatitis B virus re-infection after liver transplantation with famciclovir. Hepatology 1994; 20: 130A.
22. Colledge D, Locarnini S, Shaw T. Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology 1997; 26: 216-25.
23. Nicoll A, Angus P, Chou S, Luscombe C, Smallwood R, Locarnini S. Demonstration of duck hepatitis B virus in bile duct epithelial cells: Implications for pathogenesis and persistent infection. Hepatology 1997; 25: 463-9.
24. Blum HE, Stowring L, Figus A, Montgomery C, Haase A, Vyas G. Detection of hepatitis B virus DNA in hepatocytes, bile duct epithelium, and vascular elements by in situ hybridization. Proc. Natl. Acad. Sci. 1983; 80: 6685-8.
25. Delladetsima JK, Vafiadis I, Tassopoulos NC, Kyriakou V, Apostolaki A, Smyrnoff T. HBcAg and HBsAg expression in ductular cells in chronic hepatitis B. Liver 1994; 14: 71-5.
26. Nicoll A, Locarnini S, Chou S, Smallwood R, Angus P. Human hepatitis B virus infection of bile duct epithelial cells. Hepatology 1996; 24: 221A.
27. Luscombe C, Locarnini S. The mechanism of action of antiviral agents in chronic hepatitis B. Viral Hepatitis 1996; 2: 1-35.
28. Wang Y, Bowden S, Shaw T et al. Inhibition of duck hepatitis B virus replication in vivo by the nucleoside analogue ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine). Antiviral Chem. Chemother. 1991; 2: 107-14.
29. Wang Y, Luscombe C, Bowden S, Shaw T, Locarnini S. Inhibition of duck hepatitis B virus DNA replication by antiviral therapy with ganciclovir-nalidixic acid. Antimicrob. Agents Chemother. 1995; 39: 556-8.
30. Nicoll A, Colledge D, Toole J, Angus P, Smallwood R, Locarnini S. Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl) adenine (PMEA), an acyclic phosphonate nucleoside analogue. Antimicrob. Agents Chemother. 1998; 42: 3130-5.
31. Freiman JS, Jilbert AR, Dixon RJ et al. Experimental duck hepatitis B virus infection: Pathology and evolution of hepatic and extrahepatic infection. Hepatology 1988; 8: 507-13.
32. Civitico G, Wang YY, Luscombe CA et al. Antiviral strategies in chronic HBV infection II. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds. J. Med. Virol. 1990; 31: 90-7.
33. Nicoll AJ, Koppinen J. A technique for general anaesthesia and bile duct ligation in Pekin ducklings. Scand. J. Animal Lab. Sci. 1996; 229-32.
34. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-5.
35. Jilbert AR, Freiman JS, Burrell CJ et al. Virus-liver cell interactions in duck hepatitis B virus infection. A study of virus dissemination within the liver. Gastroenterology 1988; 95: 1375-82.
36. Shaw T, Amor P, Civitico G, Boyd M, Locarnini S. In vitro antiviral activity of penciclovir, a novel purine nucleoside, against duck hepatitis B virus. Antimicrob. Agents Chemother. 1994; 38: 719-23.
37. Jilbert AR, Wu TT, England JM et al. Rapid resolution of duck hepatitis B virus infections occurs after massive hepatocellular involvement. J. Virol. 1992; 66: 1377-88.
38. Jilbert AR, Freiman JS, Gowans EJ, Holmes M, Cossart YE, Burrell CJ. Duck hepatitis B virus DNA in liver, spleen, and pancreas: Analysis by in situ and Southern blot hybridization. Virology 1987; 158: 330-8,
39. Vere Hodge RA. Famciclovir and penciclovir. The mode of action of famciclovir including its conversion to penciclovir. Antiviral Chem. Chemother. 1993; 4: 67-84.
40. McMillan JS, Shaw T, Angus PW, Locarnini SA. Effect of immunosuppressive and antiviral agents on hepatitis B virus replication in vitro. Hepatology 1995; 22: 36-43.
41. Boyd M, Safrin S, Kern E. Penciclovir. A review of its spectrum of activity, selectivity and cross-resistant pattern. Antiviral Chem. Chemother. 1993; 4 (Suppl.): 3-11.