Regulatory circuits in Caulobacter

Current Opinion in Microbiology

Volumn 3, Issue 2, 2000, Pages 171-176

  Østerås, Magne ^a   Jenal, Urs ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN HISTIDINE KINASE; PROTEIN KINASE;

CAULOBACTER CRESCENTUS; CELL CYCLE; CELL DIVISION; DNA METHYLATION; DNA REPLICATION; ENZYME LOCALIZATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PROTEIN PHOSPHORYLATION; REVIEW; TRANSCRIPTION REGULATION;

CAULOBACTER; CAULOBACTER VIBRIOIDES;

EID: 0034027128     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00071-0     Document Type: Review

References (33)

1. Quon K.C., Marczynski G.T., Shapiro L. Cell cycle control by an essential bacterial two-component signal transduction protein. Cell. 84:1996;83-93.
2. Wu J., Ohta N., Newton A. An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci USA. 95:1998;1443-1448. The authors present genetic evidence that the essential single-domain response regulator DivK is involved in CtrA activation. A biochemical analysis demonstrates that the sensor kinase DivJ phosphorylates DivK preferentially over CtrA. The authors also show that the phosphorylated form of CtrA is required for in vitro transcription of a flagellar gene. This work postulates that a multicomponent phosphorelay is involved in CtrA activation in Caulobacter.
3. Reisenauer A., Quon K., Shapiro L. The CtrA response regulator mediates temporal control of gene expression during the Caulobacter cell cycle. J Bacteriol. 181:1999;2430-2439. The authors show that the differential temporal control of CtrA-regulated genes during the cell cycle can in part be explained by the different affinity of phosphorylated CtrA for their promoters, thus correlating the timing of transcription with the cellular levels of CtrA.
4. Stephens C., Reisenauer A., Wright R., Shapiro L. A cell cycle-regulated bacterial DNA methyltransferase is essential for viability. Proc Natl Acad Sci USA. 93:1996;1210-1214.
5. Stephens C.M., Zweiger G., Shapiro L. Coordinate cell cycle control of a Caulobacter DNA methyltransferase and the flagellar genetic hierarchy. J Bacteriol. 177:1995;1662-1669.
6. Wright R., Stephens C., Zweiger G., Shapiro L., Alley M.R. Caulobacter Lon protease has a critical role in cell-cycle control of DNA methylation. Genes Dev. 10:1996;1532-1542.
7. Kelly A.J., Sackett M.J., Din N., Quardokus E., Brun Y.V. Cell cycle dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter. Genes Dev. 12:1998;880-893. This work provides the regulatory basis for the observation that the cytokinesis protein FtsZ is not present in non-replicating swarmer cells. The cell cycle control of FtsZ includes CtrA-regulated expression and cell type-specific proteolysis. Newly synthesized FtsZ is stable when it is assembled at mid-cell at the beginning of the cell cycle. FtsZ degradation seems to be coupled to its disassembly after cell division.
8. Sackett M.J., Kelly A.J., Brun Y.V. Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle. Mol Microbiol. 28:1998;421-434. This paper demonstrates that the ftsQA genes are transcribed independently of and in sequence with ftsZ during the cell cycle.
9. Rothfield L.I., Justice S.S. Bacterial cell division: the cycle of the ring. Cell. 88:1997;581-584.
10. Quon K.C., Yang B., Domian I.J., Shapiro L., Marczynski G.T. Negative control of bacterial DNA replication by a cell cycle regulatory protein that binds at the chromosome origin. Proc Natl Acad Sci USA. 95:1998;120-125. The authors describe the mechanisms of DNA replication control by CtrA. CtrA represses the initiation of DNA replication by binding to five CtrA boxes inside the origin of replication. This restricts replication initiation to the phase of the cell cycle when CtrA is not present in the cell.
11. Marczynski G.T., Lentine K., Shapiro L. A developmentally regulated chromosomal origin of replication uses essential transcription elements. Genes Dev. 9:1995;1543-1557.
12. Domian I.J., Quon K.C., Shapiro L. Cell type-specific phosphorylation and proteolysis of a transcriptional regulator controls the G1-to-S transition in a bacterial cell cycle. Cell. 90:1997;415-424.
13. Domian I.J., Reisenauer A., Shapiro L. Feedback control of a master bacterial cell-cycle regulator. Proc Natl Acad Sci USA. 96:1999;6648-6653. This work explains the mechanisms of ctrA transcriptional autoregulation. Two ctrA promoters are active in the early and late predivisional cells, respectively. The first is repressed by CtrA and thus activated after the initiation of DNA replication when the regulator is absent. The accumulation of CtrA will then activate the second promoter resulting in high CtrA levels in late predivisional cells.
14. Jenal U., Fuchs T. An essential protease involved in bacterial cell cycle control. EMBO J. 17:1998;5658-5669. The authors demonstrate that the Caulobacter ClpXP protease is required for cell cycle progression and for CtrA degradation during the G1 to S transition.
15. Østerås M., Stotz A., Schmid Nuoffer S., Jenal U. Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease. J Bacteriol. 181:1999;3039-3050.
16. Zhou Y., Gottesman S. Regulation of proteolysis of the stationary-phase sigma factor RpoS. J Bacteriol. 180:1998;1154-1158.
17. Tatsuta T., Tomoyasu T., Bukau B., Kitagawa M., Mori H., Karata K., Ogura T. Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo. Mol Microbiol. 30:1998;583-593.
18. Turgay K., Hahn J., Burghoorn J., Dubnau D. Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17:1998;6730-6738.
19. Becker G., Klauck E., Hengge-Aronis R. Regulation of RpoS proteolysis in Escherichia coli: the response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. Proc Natl Acad Sci USA. 96:1999;6439-6444.
20. Perraud A.L., Weiss V., Gross R. Signalling pathways in two-component phosphorelay systems. Trends Microbiol. 7:1999;115-120.
21. Wu J., Ohta N., Zhao J., Newton A. A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci USA. 96:1999;13068-13073. This paper shows that the sensor kinase, DivL, which autophosphorylates on a tyrosine instead of the usual histidine residue, can phosphorylate CtrA in vitro. The divL gene is essential for viability of Caulobacter. The lethal phenotype of a divL mutant can be suppressed by a mutant allele of ctrA linking the DivL sensor to the CtrA regulatory network.
22. Jacobs C., Domian I.J., Maddock J.R., Shapiro L. Cell cycle-dependent polar localization of an essential bacterial histidine kinase that controls DNA replication and cell division. Cell. 97:1999;111-120. This paper describes the identification of CckA, a sensor kinase required for phosphorylation of CtrA in vivo. CckA is a membrane-bound protein that localizes to the swarmer pole in the early predivisional cell, but is evenly distributed during the rest of the cell cycle. Evidence is presented suggesting that correct localization of CckA is important for its activity.
23. Hecht G.B., Lane T., Ohta N., Sommer J.M., Newton A. An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J. 14:1995;3915-3924.
24. Ohta N., Lane T., Ninfa E.G., Sommer J.M., Newton A. A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation. Proc Natl Acad Sci USA. 89:1992;10297-10301.
25. Wheeler R., Shapiro L. Differential localization of two histidine kinases controlling bacterial cell differentiation. Mol Cell. 4:1999;683-694. The two sensor kinases, PleC and DivJ, show a distinct pattern of subcellular localization during the cell cycle. PleC is localized to the swarmer pole of late predivisional cells and is replaced at this site by DivJ during the swarmer to stalk transition. Interestingly, correct localization of DivJ requires PleC.
26. Appleby J.L., Parkinson J.S., Bourret R.B. Signal transduction via the multi-step phosphorelay: not necessarily a road less traveled. Cell. 86:1996;845-848.
27. Ohta N., Grebe T.W., Newton A. Signal transduction and cell cycle checkpoints in developmental regulation of Caulobacter. Brun Y.V., Shimkets L.J. Prokaryotic Development. 1999;341-359 ASM Press, Washington, DC.
28. Wang S.P., Sharma P.L., Schoenlein P.V., Ely B. A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus. Proc Natl Acad Sci USA. 90:1993;630-634.
29. Reisenauer A., Kahng L.S., McCollum S., Shapiro L. Bacterial DNA methylation: a cell cycle regulator? J Bacteriol. 181:1999;5135-5139.
30. Dingwall A., Zhuang W.Y., Quon K., Shapiro L. Expression of an early gene in the flagellar regulatory hierarchy is sensitive to an interruption in DNA replication. J Bacteriol. 174:1992;1760-1768.
31. Stephens C.M., Shapiro L. An unusual promoter controls cell-cycle regulation and dependence on DNA replication of the Caulobacter fliLM early flagellar operon. Mol Microbiol. 9:1993;1169-1179.
32. Jensen R.B., Shapiro L. The Caulobacter crescentus smc gene is required for cell cycle progression and chromosome segregation. Proc Natl Acad Sci USA. 96:1999;10661-10666. The authors used fluorescence in situ hybridization to show that the Caulobacter origins of replication move to opposite cell poles immediately after initiation of replication. A conditionally lethal smc null mutant results in abnormal DNA positioning and cell cycle arrest at the predivisional stage. Arrested smc mutants complete DNA replication but fail to build up CtrA levels. This observation proposes a segregation checkpoint upstream of CtrA activity in the predivisional cell.
33. Mohl D.A., Gober J.W. Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus. Cell. 88:1997;675-684.