Effects of neural blocking agents on motor activity and secretion in the proximal and distal rat colon: Evidence of marked segmental differences in nicotinic receptor activity

Scandinavian Journal of Gastroenterology

Volumn 35, Issue 4, 2000, Pages 380-388

  Sun, Y ^a   Fihn, B M ^a   Jodal, M ^a   Sjövall, Henrik ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Colonic motility; Myenteric plexus; Secretion; Transmural potential difference

Indexed keywords

ATROPINE; HEXAMETHONIUM; LIDOCAINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COLON MOTILITY; COLON SECRETION; CONTROLLED STUDY; DESCENDING COLON; MALE; MOTOR ACTIVITY; MYENTERIC PLEXUS; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034026938     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655200750023949     Document Type: Article

References (23)

1. 1. Cooke HJ. Neural regulation of intestinal electrolyte transport. In: Johnson LR, editor. Physiology of the gastrointestinal tract. Vol 2, 3rd ed. New York: Raven Press; 1994. p. 2083-132.
2. 2. Jodal M, Lundgren O. Neural reflex modulation of intestinal epithelial transport. In: Gaginella TS, editor. Regulatory mechanisms in gastrointestinal function. New York: CRC Press; 1995. p. 99-144.
3. 3. Greenwood B, Davison JS. The relationship between gastrointestinal motility and secretion. Am J Physiol 1987;252:G1-7.
4. 4. Baxter PS, Read NW, Hardcastle PT, Wilson AJ, Hardcastle J, Taylor Y. Abnormal jejunal potential difference in cystic fibrosis. Lancet 1989;1:464-6.
5. 5. Greenwood B, Diamant S, Davison JS. The relationship between motor activity and transmural potential difference in the guinea pig intestine in vitro: is there a neural link? Can J Physiol Pharmacol 1986;64:993-8.
6. 6. See NA, Greenwood B, Bass P. Submucosal plexus alone integrates motor activity and epithelial transport in rat jejunum. Am J Physiol 1990;259:G593-8.
7. 7. Jodal M, Holmgren S, Lundgren O, Sjöqvist A. Involvement of the myenteric plexus in cholera-toxin induced net fluid secretion in the rat small intestine. Gastroenterology 1993;105:1286-93.
8. 8. Jodal M, Wingren U, Jansson M, Heidemann M, Lundgren O. Nerve involvement in fluid transport in the inflamed rat jejunum. Gut 1993;34:1526-30.
9. 9. Kirsner JB, Shorter RG, editors. Inflammatory bowel disease. 4th ed. Baltimore (MD): Williams & Wilkins; 1995. p. 1-1034.
10. 10. McCafferty DM, Sharkey KA, Wallace JL. Beneficial effects of lidocaine in experimental colitis. Am J Physiol 1994;266: G560-7.
11. 11. Björck S, Jennische E, Dahlström A, Ahlman H. Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. Dig Dis Sci 1997;42:824-32.
12. 12. Russel MG, Volovics A, Schoon EJ, van Wijlick EH, Logan RF, Shivananda S, et al. Inflammatory bowel disease: is there any relation between smoking status and disease presentation? European Collaborative IBD Study Group, Inflamm Bowel Dis 1998;4:182-6.
13. 13. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995; 109:1344-67.
14. 14. Franks CM, Hardcastle J, Hardcastle PT. Neural involvement in 5-hydroxytryptamine-induced net electrogenic ion secretion in the rat intestine in-vivo. J Pharm Pharmacol 1996;48:411-6.
15. 15. Schulzke JD, Fromm M, Hegel U, Riecken E-O. Ion transport and enteric nervous system (ENS) in rat rectal colon: mechanical stretch causes Cl-secretion via plexus Meissner and amiloride-sensitive electrogenic Na-absorption is not affected by intramural neurons. Pflugers Arch 1989;414:216-21.
16. 16. Satoshi I, Shiratori K, Takahashi T, Ishikawa M, Kancko K, Suzuki Y. Stimulation of intramural secretory reflex by luminal distension pressure in rat distal colon. Am J Physiol 1992;263: G108-14.
17. 17. Frieling T, Wood JD, Cooke HJ. Submucosal reflexes: distension-evoked ion transport in the guinea pig distal colon. Am J Physiol 1992;263:G91-6.
18. 18. Orlando RC, Croom RD, Berschneider HM, Boucher RR, Knowles MR. Colonie and esophageal transepithelial potential difference in cystic fibrosis. Gastroenterology 1989;96:1041-8.
19. 19. Edmonds CJ. Amiloride sensitivity of the transepithelial electrical potential and of sodium and potassium transport in rat distal colon in vivo. J Physiol 1981;313:547-59.
20. 20. Turnamian SG, Binder HJ. Electrolyte transport in distal colon of sodium-depleted rats: effect of sodium repletion. Am J Physiol 1988;255:G329-38.
21. 21. Arndorfer RC, Stef JJ, Dodds WJ, Linehan JH, Hogan WJ. Improved infusion system for intraluminal esophageal manometry. Gastroenterology 1977;73:23-7.
22. 2 receptors mediate cyclical chloride secretion in guinea pig distal colon. Am J Physiol 1990;258: G887-93.
23. 23. Cassuto J, Jodal M, Lundgren O. The effect of nicotinic and muscarinic receptor blockade on cholera toxin induced intestinal secretion in rats and cats. Acta Physiol Scand 1982;114:573-7.