Studies of indomethacin inserts prepared using water-soluble polymers I. Effect of the preparation method and polymers on drug release

S.T.P. Pharma Sciences

Volumn 10, Issue 2, 2000, Pages 187-193

  Karatas, A ^a   Baykara, T ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Compression molding method; Film casting method; Indomethacin; Ophthalmic insert; Water soluble polymers

Indexed keywords

HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; METHYLCELLULOSE; POLYMER; POLYVINYL ALCOHOL;

ARTICLE; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; HYDROPHILICITY; VISCOSITY;

EID: 0034026330     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. SAETTONE M.F., GIANNACCINI B., CHETONI P., GALLI G. and CHIELLINI, E. - Vehicle effects in ophthalmic bioavailability: an evaluation of polymeric inserts containing pilocarpine. - J. Pharm.Pharmacol., 36 , 229-234, 1984.
2. GREAVES J.L., OLEJNIK O. and WILSON, C.G. - Polymers and the precorneal tear film. - S.T.P. Pharma Sci., 2 , 13-33, 1992.
3. FRIEDBERG M.L., PLEYER U., MONDINO B.J. - Device drug delivery to the eye, collagen shields, iontophoresis, and pumps. -Ophthalmology, 98 , 725-732,1991.
4. BAWA R. - Ocular inserts. -In: Ophthalmic Drug Delivery Systems, Mitra, A. K. Ed., Marcel Dekker, Inc., New York, 1993, pp. 223-260.
5. FRAUNFELDER F.T. and HANNA C. - Ophthalmic drug delivery systems. - Surv. Ophthalmol., 18 , 292-298, 1974.
6. GURTLER F. and GURNY R.-Patent literature review of ophthalmic inserts. - Drug Dev. Ind. Pharm., 21 , 1-18, 1995.
7. FLACK A.J.-Non-steroidal anti-inflammatory drugs in ophthalmology. Int. Ophthalmol. clin., 33, 1-7, 1993.
8. URTTI A., SALMINEN L. and MIINALAINEN O. - Systemic absorption of ocular pilocarpine is modified by polymer matrices. - Int.J. Pharm., 23, 147-161, 1985.
9. URTTI A., JUSLIN M. and MIINALAINEN O. - Pilocarpine release from hydroxypropylcellulose-polyvinylpyrrolidone matrices.-Int.J. Pharm., 25, 165-178, 1985.
10. BONDI J.V. and HARWOOD R.J. - Biosoluble ocular insert.-US Patent 4 730 013, 8 Mar., 1988.
11. KARATAS A. - Preparation of the ophthalmic inserts containing non-steroidal anti-inflammatory drugs. - Ph.D Thesis, Ankara University, Turkey ,1996.
12. HUSSAIN A.A., HIGUCHI T. and SHELL J.W. - Bioerodible ocular device.-US Patent 3 960 150, 1 Jun., 1976.
13. MARTIN A.N., SWARBRICK J., CAMMARATA A. - Physical Pharmacy. 2nd ed., Lea and Febiger, Philadelphia, 1970, pp. 353-372.
14. BORODKIN S., TUCKER F. E. - Drug release from hydroxpropyl cellulose-polyvinyl acetate films.-J. Pharm. Sci., 63, 1359-1363, 1974.
15. DUMORTIER G., ZUBER M., CHAST F., SANDOUK P. and CHAUMEIL J.C.-Comparison between a thermo-reversible gel and an insert in order to prolong the systemic absorption of morphine after ocular administration.-S.T.P. Pharma Sci., 2(1), 111-117, 1992.
16. ROBERT C.C.R., BURI P.A. and PEPPAS M.A. - Influence of drug solubility and dissolution medium on the release from poly (2 - hydroxyethyl methacrylate) microspheres.-J. Contr. Rel., 5 , 151-157, 1987.
17. NAKANO M., OHMORI N., OGATA A., SUGIMOTO K., TOBINO Y., IWAOKU R. and JUNI K. -Sustained release of theophylline from hydroxypropylcellulose tablets.-J. Pharm. Sci., 72, 378-380, 1983.
18. HABIB F.S. and ATTIA M.A. - Ocular delivery of pilocarpine hydrochloride from water-soluble polymeric inserts. - Acta Pharm.Technol. 32(3), 133-136, 1986.
19. LAPIDUS H. and LORDI N.G. - Some factors affecting the release of a water-soluble drug from a compressed hydrophilic matrix. - J. Pharm. Sci., 55, 840-843,1966.
20. KORSMEYER R.W. and PEPPAS N.A.-Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs.-J. Membr.Sci., 9, 211 -227, 1981.
21. LAPIDUS H. and LORDI N.G.-Drug release from compressed hydrophilic matrices-J. Pharm. Sci., 57, 1292-1301, 1968.
22. WADE A. and WELLER P.J. - Handbook of Pharmaceutical Excipients. - Second Edition, American Pharmaceutical Association and The Pharmaceutical Press, Washington and London, 1994, pp.223-228, 306-309.
23. UEBERREITER K., The solution process. In: Diffusion in Polymers, Crank, J. and Park, G.S. Eds., Academic Press, London, 1968, pp. 219-257.
24. OKHAMAFE A.O. and YORK P. - Moisture permeation mechanism of some aqueous-based film coats. - J. Pharm. Pharmacol., 34 , 53P, 1982.