Inhibition of proliferation of human peripheral blood mononuclear cells by calcium antagonists. Role of interleukin-2

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 1, 2000, Pages 19-23

  Petrov, V ^a   Lijnen, P ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Interleukin 2; Mibefradil; Mononuclear cells; Nifedipine; Proliferation

Indexed keywords

CALCIUM ANTAGONIST; CONCANAVALIN A; INTERLEUKIN 2; MIBEFRADIL; NIFEDIPINE;

ARTICLE; BINDING SITE; CALCIUM METABOLISM; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; HYPERTENSION; MONONUCLEAR CELL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR BLOCKING; SUPERNATANT; T LYMPHOCYTE ACTIVATION;

EID: 0034024387     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.1.795799     Document Type: Article

References (17)

1. Bühler, F.R., Fleckenstein-Grün, G. A new class of calcium antagonists: From molecular biology to clinical benefit. J Cardiovasc Pharmacol 1996, 27: S1-26.
2. Oparil, S., Kobrin, I., Abernethy, D.R., Levine, B.S., Reif, M.C., Shepherd, A.M. Dose-response characteristics of mibefradil, a novel calcium antagonist in the treatment of essential hypertension. Am J Hypertens 1997, 10: 735-42.
3. Viskoper, R.J., Bernink, P.J.L.M., Schelling, A. et al. A randomised, double-blind trial comparing mibefradil amtodipine: Two long-acting calcium antagonist with similar efficacy but different tolerability profiles. J Hum Hypertens 1997, 11: 387-93.
4. 2+ channel in cardiac tissue. Eur J Pharmacol 1995, 290: 155-8.
5. 2+-channels by Ro40-5967. Circ Res 1944, 75: 144-8.
6. Lijnen, P., Saavedra, A., Petrov, V. In vitro proliferative response of human peripheral blood mononuclear cells to concanavalin A. Clin Chim Acta 1997, 264: 91-101.
7. Korzeniewski, C., Callewaert, D.M. An enzyme-release assay for natural cytotoxicity. J. Immunol Methods 1983, 64: 313-20.
8. Stevens, C., Lipmann, M., Fabry, S. et al. 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. J Pharmacol Exp Ther 1995, 272: 399-406.
9. Gillies, R.J., Diedier, N., Denton, M. Determination of cell number in monolayer cultures. Anal Biochem 1986, 159: 109-13.
10. Janossy, G., Amlot, P. Immunofluoroscence and immunochemistry. Lymphocytes: A practical approach. Klaus, C.G.B. (Ed.). IRL Press: Oxford 1987, 67-108.
11. Smith, K.A., Wang, H.M., Cantrell, D. Yamamura, V.J., Tida, T., (Eds.). Progress in Immunology V. Academic Press: New York 1984, 269.
12. Mills, G.B., Cheung, R.K., Grinstein, S., Gelfand, E.W. Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin-2 but not for expression of the interleukin-2 receptor, Immunology 1985a, 134: 1640-43.
13. Mills, G.B., Cheung, R.K., Grinstein, S., Gelfand, E.W. Interleukin-2-induced lymphocyte proliferation is independent of increase in cytosolic free calcium concentration. Immunology 1985b, 134: 2431-35.
14. Gelfand, E.W., Cheung, R.K., Grinstein, S., Mills, G.B. Characterization of the role of calcium influx in mitogen-induced triggering of human T-cells. Identification of calcium-dependent and calcium-independent signals. Eur J Immunol 1986, 16:907-12.
15. Morgano, A., Pierri, I., Stagnaro, R., Sefti, M., Puppo, F., Indiveri, F. Decreased lymphocyte blastogenesis, IL-2 production and NK activity following nifedipine administration to healthsy humans. Eur J Clin Pharmacol 1990, 39: 545-50.
16. Robb, R.J., Greene, W.C., Rusk, C.M. Low and high affinity cellular receptors for interleukin-2. Implications for the level of Tac antigens. J Exp Med 1984, 160: 1126-46.
17. Smith, K.A., Cantrell, D.A. Interleukin-2 regulates its own receptors. Proc Natl Acad Sci USA 1985, 82: 864-8.