Chiral separations of metoprolol and some analogs with carbon dioxide on Chiralcel OD and Chiralpak AD stationary phases. Use of chemometrics

Chromatographia

Volumn 51, Issue 5-6, 2000, Pages 283-293

  Svensson, S ^a   Karlsson, A ^a   Gyllenhaal, O ^a   Vessman, J ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Amino alcohols; Enantiomer separation; Statistical experimental design; Supercritical fluid chromatography

Indexed keywords

ACETIC ACID; ALKYL GROUP; AMINOALCOHOL; AMYLOSE; CARBENE; CARBON DIOXIDE; CELLULOSE; METHANOL; METOPROLOL; N,N DIMETHYLOCTYLAMINE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG PURITY; DRUG STRUCTURE; ENANTIOMER; FACTORIAL ANALYSIS; PRIORITY JOURNAL; STEREOCHEMISTRY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE;

EID: 0034024085     PISSN: 00095893     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02490605     Document Type: Article

References (30)

1. [1] R. Howe, R. G. Shanks, Nature 210, 1136 (1966).
2. [2] C.J. Bailey, R.J. Ruane, I.D. Wilson, J. Chromatogr. Sci. 32, 426 (1994).
3. [3] L. Siret, N. Bargmann, A. Tambuté, M. Caude, Chirality 4, 252 (1992).
4. [4] N. Bargmann-Leyder, D. Thiébaut, F. Vergne, A. Bégos, A. Tambuté, M. Caude, Chromatographia 39, 673 (1994).
5. [5] K. L. Williams, L. C. Sander, S. A. Wise, Chirality 8, 325 (1996).
6. [6] A. Kot, P. Sandra, A. Venema, J. Chromatogr. Sci. 32, 439 (1994).
7. [7] P. Biermanns, C. Miller, V. Lyon, W. Wilson, LC-GC 11, 744 (1993).
8. [8] C. R. Lee, J.-P. Porziemsky, M. C. Aubert, A. M. Krstulovic, J. Chromatogr. 539, 55 (1991).
9. [9] N. Bargmann-Leyder, A. Tambuté, M. Caude, Chirality 7, 311 (1995).
10. [10] J. Whatley, J. Chromatogr. 697, 251 (1995).
11. [11] K. G. Lynam, E. C. Nicolas, J. Pharm. Biomed. Anal. 11/12, 1197(1993).
12. [12] R. J. Smith, D. R. Taylor, S. M. Wilkins, J. Chromatogr. 697, 591 (1995).
13. [13] L. Siret, P. Macaudière, N. Bargmann-Leyder, A. Tambuté, M. Caude, E. Gougeon, Chirality 6,440(1994).
14. [14] T. Loughlin, R. Thompson, G. Bicker, P. Tway, N. Grinberg, Chirality 8, 157 (1996).
15. [15] P. Macaudière, M. Caude, R. Rosset, A. Tambuté, J. Chromatogr. Sci. 27, 583 (1989).
16. [16] R.W. Stringham, J. A. Blackwell, Anal. Chem. 68, 2179 (1996).
17. [17] G. O. Cantrell, R. W. Stringham, J. A. Blackwell, J. D. Weckwerth, P. W. Carr, Anal. Chem. 68, 3645 (1996).
18. [18] A. Höskuldsson, J. Chemometrics 2, 211 (1988).
19. [19] G. E. P. Box, W. G. Hunter, J. S. Hunter, Statistics for Experimenters, John Wiley & Sons, New York, USA, 1983.
20. [20] S. Wold, Technometrics 20, 397(1978).
21. [21] P. Geladi, B. R. Kowalski, Anal. Chim. Acta 185, 1 (1986).
22. [22] U. Selditz, S. Copinga, J. P. Franke, H. Wikström, R. A. de Zeeuw, Chirality 8, 574 (1996).
23. [23] R. Kaliszan (Ed), Structure and Retention in Chromatography. A Chemometric Approach, Harvard Academic Publications, 1997.
24. [24] K. Anton, J. Eppinger, L. Frederiksen, E. Francotte, T. A. Berger, W. H. Wilson, J. Chromatogr. 666, 395 (1994).
25. [25] Y. Tang, Chirality 8, 136 (1996).
26. [26] W. H. Pirkle, J. Chromatogr. 558, 1 (1991).
27. [27] J. Dönneke, L. A. Svensson, O. Gyllenhaal, K. E. Karlsson, A. Karlsson, J. Vessman, J. Microcol. Sep. 11, 521 (1999).
28. [28] R. W. Stringham, Chirality 8, 249 (1996).
29. [29] S. Svensson, A. Karlsson, J. Vessman, J. Chromatogr. 839, 23 (1999).
30. [30] H. Y. Aboul-Enein, L. I. Abou-Basha, S. A. Bakr, Chirality 8, 153 (1996).