Recent advances in the diagnosis and management of infection in the organ transplant recipient

Seminars in Nephrology

Volumn 20, Issue 2, 2000, Pages 148-163

  Tolkoff Rubin, Nina E ^a   Rubin, Robert H ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; COTRIMOXAZOLE; CYCLOSPORIN; FLUCONAZOLE; FLUCYTOSINE; GANCICLOVIR; IMMUNOSUPPRESSIVE AGENT; TACROLIMUS; VALACICLOVIR;

ANTIGEN DETECTION; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; GRAFT INFECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MORBIDITY; MORTALITY; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; TREATMENT PLANNING;

ANTI-INFECTIVE AGENTS; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; INFECTION; MYCOSES; ORGAN TRANSPLANTATION; VIRUS DISEASES;

EID: 0034023907     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (75)

1. Rubin RH: Infections in the organ transplant recipient, in Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host (ed 3). New York, Plenum, 1994, pp 629-705
2. Fishman JA, Rubin RH: Infection in organ-transplant recipients. N Eng J Med 338:1741-1751, 1998
3. Rubin RH, Greene R: Clinical approach to the compromised host with fever and pulmonary infiltrates, in Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host (ed 3). New York, Plenum, 1994, pp 121-161
4. Kuhlman JE, Fishman EK, Hruban RH, et al: Disease of the chest in AIDS: CT diagnosis. RadioGraphics 9:827-857, 1989
5. Kuhlman JE, Knowles M, Fishman EK, et al: Premature bullous damage in AIDS: CT diagnosis. Radiology 173:23-26, 1989
6. Barloon TJ, Calvin JR, Mori M, et al: High-resolution ultrafast chest CT in the clinical management of febrile bone marrow transplant patients with normal or nonspecific chest roentgenograms. Chest 99:928-933, 1991
7. Kuhlman JE, Fishman EK, Siegelman SS: Invasive pulmonary aspergillosis in acute leukemia: Characteristic findings on CT, the CT halo sign and the role of CT in early diagnosis. Radiology 157:611-614, 1985
8. Murray JF, Mills J: Pulmonary infectious complications of human immunodeficiency virus infection: Parts I and II. Am Rev Resp Dis 141:1356-1372, 1990
9. Barrio JL, Suarez M, Rodriguesz JL, et al: Pneumocystis carinii pneumonia presenting as cavitating and non cavitating solitary pulmonary nodules in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis 134:1094-1096, 1986
10. Plunkett MB, Peterson MS, Landereneau RI, et al: Peripheral pulmonary nodules: Preoperative percutaneous needle localization with CT guidance. Radiology 185:274-276, 1992
11. Naidich DP, Sussman R, Kutcher WL, et al: Solitary pulmonary nodules: CT-bronchoscopic correlation. Chest 3:595-598, 1998
12. Janzen DL, Adler BD, Padley SPG, et al: Diagnostic success of bronchoscopic biopsy in immunocompromised patients with acute pulmonary disease: Predictive value of disease distribution as shhown on CT. AJR Am J Roentgenol 160:21-24, 1993
13. Tunkel AR, Scheld WM: Central nervous system infection in the immunocompromised host, in Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host (ed 3). New York, Plenum, 1994, pp 163-210
14. Aksamit AJ: Central nervous system, in Bowden RA, Ljungman P, Paya CV (eds): Transplant Infections. Philadelphia, Lippincott-Raven Publishers, 1998, pp 133-151
15. Cockerill FR III: Diagnosis of bacterial and parasitic infection, in Bowden RA, Ljungman P, Paya CV (eds): Transplant Infections. Philadelphia, Lippincott-Raven Publishers, 1998, pp 37-49
16. Powderly WG, Cloud GA, Dismukes WE, Saag MS: Measurement of cryptococcal antigen in serum and cerebrospinal fluid: Value in the management of AIDS-associated cryptococcal meningitis. Clin Infect Dis 18:789-792, 1994
17. Tanner DC, Weinstein MP, Fedorciw B, et al: Comparison of commercial kits for detection of cryptococcal antigen. J Clin Microbiol 32:1680-1684, 1994
18. Thé TH, van der Bij W, van der Berg AP, et al: Cytomegalovirus antigenemia. Rev Infect Dis 12:5737-5744, 1990 (suppl 7)
19. Grefte A, Blom N, van der Giesson M, et al: Ultrastructural analysis of circulating cytomegalic cells in patients with active cytomegalovirus infection: Evidence for virus production and endothelial origin. J Infect Dis 168:1110-1118, 1993
20. Grefte JM, van der Gun BT, Shmolke S, et al: The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection. J Gen Virol 73:2923-2932, 1992
21. Van den Berg AP, Klompmaker IJ, Haagsma EB, et al: Antigenemia in the diagnosis and monitoring of active cyto-megalovirus infection after liver transplantation. J Infect Dis 164:265-270, 1991
22. Van den Berg AP, Tegzess AM, Scholten-Sampson A, et al: Monitoring antigenemia is useful in guiding treatment of severe cytomegalovirus disease after organ transplantation. Transplant Int 5:101-106, 1992
23. Mazzulli T, Rubin RH, Ferraro MJ, et al: Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS. J Clin Microbiol 31:2824-2827, 1993
24. Thé TH, van den Berg AP, Harmsen MC, et al: The cytomegalovirus antigenemia assay: A plea for standarization. Scand J Infect Dis 99:25-29, 1995 (suppl)
25. Englund JA, Whimbey E, Atmar RL: Laboratory methods for the diagnisis of respiratory viral dieases, in Bowden RA, Ljungman P, Paya CV (eds): Transplant Infections. Philadelphia, Lippincott-Raven Publishers, 1998, pp 63-77
26. Griffiths PD, Cope AV, Hassan-Walker AF, et al: Diagnostic approach to cytomegalovirus infection in bone marrow and organ transplantation. Trans Infect Dis 1:179-186, 1999
27. Lake KD: Drug interactions in transplant patients, in Emery RW, Miller LW (eds): Handbook of Cardiac Transplantation. Philadelphia, Hanley & Belfus, 1995, pp 173-200
28. Venkataramanan R, Habucky K, Burckart GJ, et al: Clinical pharmacokinetics in organ transplant patients. Clin Pharmacokinet 16:134-61, 1989
29. Rubin RH, Tolkoff-Rubin NE: Antimicrobial strategies in the care of organ transplant recipients. Antimicrob Agents Chemother 37:619-624, 1993
30. Fietze E, Prosch S, Reinke P, et al: Cytomegalovirus infection in transplant recipients: The role of tumor necrosis factor. Transplantation 58:675-680, 1994
31. Reinke P, Prosch S, Kern F, et al: Mechanisms of human cytomegalovirus (HCMV) (re)activation and its impact on organ transplant recipients. Trans Infect Dis in press, 1999
32. Patel R, Paya CV: Cytomegalovirus infection and disease in solid organ transplant recipients, in Bowden RA, Ljungman P, Paya CV (eds): Transplant Infections. Philadelphia, Lippincott-Raven Publishers, 1998, pp 229-244
33. Lowance D, Neumayer HH, Legendre CM, et al: Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. International valacyclovir cytomegalovirus prophylaxis transplantation study group. N Engl J Med 340:1462-1470, 1999
34. Valantine HA, Gao SZ, Menon SG, et al: Impact of prophylactic immediate posttransplant ganciclovir on development of transplant atherosclerosis: A post hoc analysis of a randomized, placebo-controlled study. Circulation 100:61-66, 1999
35. Basgoz N, Preiksaitis J: Post-transplant lymphoproliferative disorder. Infect Dis Clin North Am 9:901-923, 1995
36. Ho M, Miller G, Atchison RW, et al: Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection. J Infect Dis 152:876-886, 1985
37. Preiksaitis JK, Cockfield SM: Epstein-Barr virus and lymphoproliferative disorders after transplantation, in Bowden RA, Ljungman P, Paya CV (eds): Transplant Infections. Philadelphia, Lippincott-Raven Publishers, 1998, pp 245-263
38. Lawrence GL, Chee M, Craxton MA, et al: Humanherpesvirus 6 is closely related to human cytomegalovirus. J Virol 64:287-299, 1990
39. Singh N, Carrigan DR: Human herpesvirus-6 in transplantation: An emerging pathogen. Ann Intern Med 124:1065-1071, 1996
40. Dockrell DH, Prada J, Jones MF, et al: Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease. J Infect Dis 176:1135-1140, 1997
41. Herbein G, Strasswimmer J, Altieri M, et al: Longitudinal study of human herpesvirus-6 infection in organ transplant recipients. Clin Infect Dis 22:171-173, 1996
42. Schmidt C, Wilbom F, Oettle H, et al: A prospective study of human herpesvirus type-6 detected by polymerase chain reaction after liver transplantation. Transplantation 61: 662-664, 1996
43. Singh N, Carrigan DR, Gayowski T, et al: Human herpesvirus-6 infection in liver transplant recipients: Documentation of pathogenicity. Transplantation 64:674-678, 1997
44. Chang FY, Singh N, Gayowski T, et al: Fever in liver transplant recipients: Changing spectrum of etiologic agents. Clin Infect Dis 26:59-65, 1998
45. Moore PS, Chang Y: Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 332:1181-1185, 1995
46. Ambroziak JA, Blackbourn DJ, Herndier BG, et al: Herpesvirus-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582-583, 1995
47. Boshoff C, Whitby D, Hatziioannou T, et al: Kaposi's sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet 345:1043-1044, 1995
48. Kedes DH, Opetskalski E, Busch M, et al: The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission. Nature Med 2:918-924, 1996
49. Cathomas G, Tamm M, McGandy CE, et al: Transplantation-associated malignancies: Restriction of human herpesvirus 8 to Kaposi's sarcoma. Transplantation 64:175-178, 1997
50. Alkan S, Karcher DS, Ortiz A, et al: Human herpesvirus8/Kaposi's sarcoma-associated herpesvirus in organ transplant patients with immunosuppression. Br J Haematol 96:412-414, 1997
51. Shepherd FA, Maher E, Cardella C, et al: Treatment of Kaposi's sarcoma after solid organ transplantation. J Clin Oncol 15:2371-2377, 1997
52. Doutrelepont JM, De Pauw L, Gruber SA, et al: Renal transplantation exposes patients with previous Kaposi's sarcoma to a high risk of recurrence. Transplantation 62:463-466, 1996
53. Rezeig Ma, Fashir BM: Kaposi's sarcoma in liver transplant recipients on FK506: Two case reports. Transplantation 63:1520-1521, 1997
54. Lock MJ, Griffiths PD, Emery VC: Development of a quantitative competitive polymerase chain reaction for human herpesvirus 8. J Virol Methods 64:19-26, 1997
55. Kedes DH, Ganem D: Sensitivity of Kaposi's sarcomaassociated herpesvirus replication to antiviral drugs. J Clin Invest 99:2082-2086, 1997
56. Fishman JA, Rubin RH, Koziel MJ, et al: Hepatitis C virus and organ transplantation. Transplantation 62:147-154, 1996
57. Terrault NA, Wright TL, Pereira BJG: Hepatitis C infection in the transplant recipient. Infect Dis Clin N Am 9:943-964, 1995
58. Agarwal SK, Dash SC, Tiwari SC, et al: Clinicopathologic course of hepatitis B infection in surface antigen carriers following living-related renal transplantation. Am J Kidney Dis 24:78-82, 1994
59. Poterucha JJ, Wiesner RH: Liver transplantation and hepatitis B. Ann Intern Med 126:805-807, 1997
60. 5Ag-positive patients. Lancet 337:813-815, 1991
61. Terrault N, Zhou S, Combs C, et al: Prophylaxis in liver transplant recipients using schedule of hepatitis B immunoglobulin. Hepatology 24:1327-1333, 1996
62. McGory R, Ishitani M, Oliveira W, et al: Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization. Transplantation 61:1358-1364, 1996
63. Grellier L, Brown D, McPhilips P, et al: Lamivudine prophylaxis new strategy for prevention of reinfection in liver transplantation for hepatitis B DNA positive cirrhosis. Hepatology 22:224A, 1995
64. Ling R, Mutimer D, Ahmed M, et al: Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 24:711-713, 1996
65. Perrillo R, Rakela J, Martin P, et al: Lamivudine for hepatitis B following liver transplantation. Hepatology 24: 182A, 1996
66. Perrillo R, Rakela J, Martin P, et al: Lamivudine for suppression and/or prevention of hepatitis B when given pre/post transplantation (OLT). Hepatology 26:261A, 1997
67. Perrillo R, Rakela J, Martin P, et al: Long-term lamivudine therapy of patients with recurrent hepatitis B post liver transplantation. Hepatology 26:177A, 1997
68. Schvarcz R, Ando Y, Sonnerborg A, et al: Combination treatment with interferon alpha-2b and ribavirin for chronic hepatitis C in patients who have failed to achieve sustained response to interferon alone: Swedish experience. J Hepatol 23:17-21, 1995 (suppl 2)
69. Lai M, Yang P, Wang JT, et al: Long-term efficacy of ribavirin plus interferon alpha in the treatment of chronic hepatitis C. Gastroenterology 111:1307-1312, 1996
70. Bizollon T, Palazzo U, Chevallier, et al: HCV recurrence after OLTX: A pilot study of ribavirin therapy following initial combination with INF. Hepatology 24:293A, 1996
71. Rubin RH, Jenkins RL, Shaw BWJ, et al: The acquired immunodeficiency syndrome and transplantation. Transplantation 44:1-4, 1987
72. Hadley S, Karchmer AW: Fungal infections in solid organ transplantation recipients. Infect Dis Clin North Am 4:1045-1074, 1995
73. Hibberd PL, Rubin RH: Clinical aspects of fungal infections in organ transplant recipients. Clin Infect Dis 19:S33-S40, 1994 (suppl 1)
74. Fishman JA, Rubin RH: Fungal infections in the organ transplant recipient: Challenges and opportunities, in Vincent JL (ed): Yearbook of Intensive Care and Emergency Medicine. Berlin, Springer-Verlag, 1996, pp 555-566
75. Tollemar J, Höckerstedt K, Ericzon BG, et al: Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients: A randomized, placebo controlled study. Transplantation 59:1:45-50, 1995