Synthesis and release of L-serine by rat astroglia-rich primary cultures

GLIA

Volumn 30, Issue 1, 2000, Pages 19-26

  Verleysdonk, Stephan ^a   Hamprecht, Bernd ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Brain amino acid metabolism; Enzyme activities; Phosphorylated pathway

Indexed keywords

AMINO ACID; AMINOTRANSFERASE; GLUCOSE; OXIDOREDUCTASE; PEPTIDE HYDROLASE; PHOSPHATASE; PHOSPHOGLYCERATE DEHYDROGENASE; PHOSPHOSERINE AMINOTRANSFERASE; PHOSPHOSERINE PHOSPHATASE; SERINE;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; BRAIN; CELL CULTURE; CYTOLOGY; ENZYMOLOGY; EXTRACELLULAR SPACE; METABOLISM; PHOSPHORYLATION; RAT; WISTAR RAT;

AMINO ACIDS; ANIMALS; ASTROCYTES; BRAIN; CARBOHYDRATE DEHYDROGENASES; CELLS, CULTURED; EXTRACELLULAR SPACE; GLUCOSE; PEPTIDE HYDROLASES; PHOSPHOGLYCERATE DEHYDROGENASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RATS; RATS, WISTAR; SERINE; TRANSAMINASES;

EID: 0034023565     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(200003)30:1<19::AID-GLIA3>3.0.CO;2-3     Document Type: Article

References (43)

1. Ames BN, Dubin DT. 1960. Polyamines in bacteriophage T4. J Biol Chem 235:769-775.
2. Bixel MG, Hamprecht B. 1995. Generation of ketone bodies from leucine by cultured astroglial cells. J Neurochem 65:2450-2461.
3. Borkenhagen LF, Kennedy EP. 1958. The enzymic equilibration of L-serine with o-phosphoserine. Biochim Biophys Acta 28:222-223.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254.
5. Chen PS, Toribara TY, Warner H. 1956. Assay of inorganic phosphate, total phosphate and phosphatases. Anal Chem 28:1756-1759.
6. Coon CN, Couch JR. 1975. Distribution studies of glycine and serine enzymes in chicks. Poultry Sci 54:116-118.
7. de Koning TJ, Duran M, Dorland L, Gooskens R, Van Schaftingen E, Jaeken J, Blau N, Berger R, Poll-The BT. 1998. Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. Ann Neurol 44:261-265.
8. Ditullio NW, Berkoff CE, Blank B, Kostos V, Stack EJ, Saunders HL. 1974. 3-Mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem J 138:387-394.
9. Goodman MN. 1975. Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver. Biochem J 150:137-139.
10. Hamprecht B, Dringen R. 1995. Energy metabolism. In: Kettenmann H, Ransom B, editors. Neuroglial cells. New York: Oxford University Press. p 473-487.
11. Hamprecht B, Loffler F. 1985. Primary glial cultures as a model for studying hormone action. Methods Enzymol 109:342-345.
12. Hashimoto A, Nishikawa T, Hayashi T, Fujii N, Harada K, Oka T, Takahashi K. 1992. The presence of free D-serine in rat brain. FEBS Lett 13:33-36.
13. Hayashi S, Tanaka T, Naito J, Suda M. 1975. Dietary and hormonal regulation of serine synthesis in the rat. J Biochem (Tokyo) 77:207-219.
14. Hirsch H, Greenberg DM. 1967. Studies on phosphoserine aminotransferase of sheep brain. J Biol Chem 242:2283-2287.
15. Hopgood MF, Ballard FJ. 1979. Regulation of protein breakdown in hepatocyte monolayers. CIBA Found Symp 75:205-218.
16. Ichihara A, Greenberg DM. 1955. Pathway of serine formation in rat liver. Proc Natl Acad Sci USA 41:605-609.
17. Ichihara A, Greenberg DM. 1957. Further studies on the pathway of serine formation from carbohydrate. J Biol Chem 224:331-340.
18. Jones BN, Gilligan JP. 1983. o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr 266:327-333.
19. Knox WE, Herzfeld A, Hudson J. 1969. Phosphoserine phosphatase distribution in normal and neoplastic tissue. Arch Biochem Biophys 132:397-403.
20. Libby P, Goldberg AL. 1978. Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. Science 199:534-536.
21. Luiken JJ, Aerts JM, Meijer AJ. 1996. The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes. Eur J Biochem 235:564-573.
22. May RC, Bailey JL, Mitch WE, Masud T, England BK. 1996. Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo. Kidney Int 49:679-683.
23. Mitoma J, Furuya S, Hirabayashi Y. 1998a. A novel metabolic communication between neurons and astrocytes: non-essential amino acid L-serine released from astrocytes is essential for developing hippocampal neurons. Neurosci Res 30:195-199.
24. Mitoma J, Kasama T, Furuya S, Hirabayashi Y. 1998b. Occurrence of an unusual phospholipid, phosphatidyl-L-threonine, in cultured hippocampal neurons. Exogenous L-serine is required for the synthesis of neuronal phosphatidyl-L-serine and sphingolipids. J Biol Chem 273:19363-19366.
25. Nagata Y, Borghi M, Fisher GH, D'Aniello A. 1995. Free D-serine concentration in normal and Alzheimer human brain. Brain Res Bull 38:181-183.
26. Neuhaus FC, Byrne WL. 1958. o-Phosphoserine phosphatase. Biochim Biophys Acta 28:223-224.
27. Paoli A, Guiraud P, Brunel C. 1974. o-Phosphoserine phosphatase from bovine brain and kidney. High molecular weight forms occurring during the purification. Biochim Biophys Acta 370:487-497.
28. Robinson BH, Oei J. 1975. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase. FEBS Lett 58:12-15.
29. Sallach HJ. 1956. Formation of serine from hydroxypyruvate. J Biol Chem 223:1101-1108.
30. Savoca R, Ziegler U, Sonderegger P. 1995. Effects of L-serine on neurons in vitro. J Neurosci Meth 61:159-167.
31. Schmoll D, Führmann E, Gebhardt R, Hamprecht B. 1995. Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme. Eur J Biochem 227:308-315.
32. Snell K. 1986. The duality of pathways for serine biosynthesis is a fallacy. Trends Biochem Sci 11:241-243.
33. Sugimoto E, Pizer LI. 1968. The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J Biol Chem 243:2081-2089.
34. Verleysdonk S, Martin H, Willker W, Leibfritz D, Hamprecht B. 1999. Rapid uptake and degradation of glycine by astroglial cells in culture: synthesis and release of serine and lactate. Glia 27:239-248.
35. Vidal Y, Cassaigne A, Neuzil E. 1985. Interactions of aminophosphonates with rat liver phosphoserine phosphatase. Biochem Soc Trans 13:788-799.
36. Voet D, Voet J. 1995. Amino acids. In: Biochemistry, 2nd ed. New York: John Wiley. p 58.
37. Walsh DA, Sallach HJ. 1965. Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase. Biochemistry 4:1076-1085.
38. Wildenthal K, Griffin EE, Ingwall JS. 1976. Hormonal control of cardiac protein and amino acid balance. Circ Res 3831:I138-I144.
39. Willis JE, Sallach HJ. 1962. Evidence for a mammalian D-3-phosphoglycerate dehydrogenase. J Biol Chem 237:910-915.
40. Willis JE, Sallach HJ. 1964. The occurrence of D-3-phosphoglycerate dehydrogenase in animal tissue. Biochim Biophys Acta 81:39-54.
41. Wolosker H, Sheth KN, Takahashi M, Mothet JP, Brady RO Jr, Ferris CD, Snyder SH. 1999. Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci USA 96:721-725.
42. Yang L, Tanaka J, Zhang B, Sakanaka M, Maeda N. 1998. Astrocytes modulate nitric oxide production by microglial cells through secretion of serine and glycine. Biochem Biophys Res Commun 251:277-282.
43. Yudkoff M. 1997. Brain metabolism of branched-chain amino acids. Glia 21:92-98.