Chronic ureteral obstruction in the rat suppresses renal tubular bcl-2 and stimulates apoptosis

Experimental Nephrology

Volumn 8, Issue 2, 2000, Pages 115-122

  Chevalier, Robert L ^a,c   Smith, Christopher D ^a   Wolstenholme, Jennifer ^a   Krajewski, Stanislaw ^b   Reed, John C ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Cystic kidney disease; Immunocytochemistry; Programmed cell death; Renal maturation; Tubular epithelial cell; Ureteral obstruction

Indexed keywords

PROTEIN BCL 2;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STAINING; URETER OBSTRUCTION;

EID: 0034023228     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000020657     Document Type: Article

References (48)

1. Chevalier RL: Effects of ureteral obstruction on renal growth. Semin Nephrol 1995;15:353-360.
2. Gobe GC, Axelsen RA: Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Lab Invest 1987;56:273-281.
3. Winyard PJD, Nauta J, Lirenman DS, Hardman P, Sams VR, Risdon RA, Woolf AS: Deregulation of cel I survival in cystic and dysplastic renal development. Kidney Int 1996;49: 135-146.
4. Kennedy WA II, Stenberg A, Lackgren G, Hensle TW, Sawczuk IS: Renal tubular apoptosis after partial ureteral obstruction. J Urol 1994; 152:658-664.
5. Chevalier RL, Chung KH, Smith CD, Ficence M, Gomez RA: Renal apoptosis and clusterin following ureteral obstruction: The role of maturation. J Urol 1996;156:1474-1479.
6. Hockenbery DM: bcl-2, a novel regulator of cell death. Bioessays 1995;17:631-638.
7. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994;124:1-6.
8. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC: Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 1993;53:4701-4714.
9. Knudson CM, Korsmeyer SJ: Bcl-2 and Bax function independently to regulate cell death. Nat Genet 1997;16:358-363.
10. Novack DV, Korsmeyer SJ: Bcl-2 protein expression during murine development. Am J Pathol 1994;145:61-73.
11. Chandler D, El-Naggar AK, Brisbay S, Redline RW, McDonnell TJ: Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: Evidence for the contribution of bcl-2 expression to renal carcinogenesis. Hum Pathol 1994;25:789-796.
12. Winyard PJD, Risdon RA, Woolf AS: WT1 expression in the absence of bcl-2 may explain excessive apoptosis which occurs in human kidney malformations (abstract). J Am Soc Nephrol 1995;6:729.
13. Chung KH, Gomez RA, Chevalier RL: Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction. Am J Physiol 1995;268:F1117-F1123.
14. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC: Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994;145:1323-1336.
15. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ, Reed JC: Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 1995;15:6364-6376.
16. Schulte BA, Spicer SS: Histochemical evaluation of mouse and rat kidneys with lectinhorseradish peroxidase conjugates. Am J Anat 1983;168:345-362.
17. Granata C, Wang Y, Puri P, Tanaka K, O'Briain DS: Decreased bcl-2 expression in segmental renal dysplasia suggests a role in its morphogenesis. Br J Urol 1997;80:140-144.
18. Liapsis H, Yu H, Steinhardt G: Apoptosis and bcl-2 in experimental fetal obstruction (abstract 63). 7th Int Workshop on Developmental Nephrology, Stockholm 1998.
19. Yoo KH, Thornhill BA, Chevalier RL: Phenotypic transformation of renal tubular epithelial cells and interstitial fibroblasts following unilateral ureteral obstruction or single nephron obstruction (abstract). J Am Soc Nephrol 1996; 7:1768.
20. Holthofer H: Cell type-specific glycoconjugates of collecting duct cells during maturation of the rat kidney. Cell Tissue Res 1988;253:305-309.
21. Chevalier RL: Chronic partial ureteral obstruction in the neonatal guinea pig. II. Pressure gradients affecting glomerular filtration rate. Pediatr Res 1984;18:1271-1277.
22. Tanaka R, Sugihara K, Tatematsu A, Fogo A: Internephron heterogeneity of growth factors and sclerosis - modulation of platelet-derived growth factor by angiotensin II. Kidney Int 1995;47:131-139.
23. Basile DP, Liapis H, Hammerman MR: Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury. Am J Physiol 1997;272:F640-F647.
24. Morrissey JJ, Ishidoya S, McCracken R. Klahr S: Control of p53 and p21 (WAF1) expression during unilateral ureteral obstruction. Kidney Int 1996;50(suppl 57):84-92.
25. Pierzchalski P, Reiss K, Cheng W, Cirielli C, Kajstura J, Nitahara JA, Rizk M, Capogrossi MC, Anversa P: p53 induces myocyte apoptosis via the activation of the renin-angiotensin system. Exp Cell Res 1997;234:57-65.
26. Yin CY, Knudson CM, Korsmeyer SJ, Van Dyke T: Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 1997;385: 637-640.
27. Reed JC, Cuddy M, Haldar S: Bcl-2 mediated tumorigenicity of a human T-lyniphoid cell line: Synergy with MYC and inhibition by bcl-2 antisense. Proc Natl Acad Sci USA 1990;87: 3600-3664.
28. Storch S, Saggi S, Megyesi J, Price PM, Safirstein R: Urcteral obstruction decreases renal prepro-epidermal growth factor and Tamm-Horsfall expression. Kidney Int 1992;42:89-94.
29. Chung KH, Chevalier RL: Arrested development of the neonatal kidney following chronic ureteral obstruction. J Urol 1996;155:1139-1144.
30. Coles HSR, Burne JF, Raff MC: Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 1993;118:777-784.
31. Kennedy WA II, Buttyan R, Garcia-Montes E, D'Agati V, Olsson CA, Sawczuk IS: Epidermal growth factor suppresses renal tubular apoptosis following ureteral obstruction. Urology 1997;49:973-980.
32. Chevalier RL, Goyal S, Wolstenholme JT, Thornhill BA: Obstructive nephropathy in the neonate is attenuated by epidermal growth factor. Kidney Int 1998;54:38-47.
33. Merilo GR, Cella N, Hynes NE: Apoptosis is accompanied by changes in Bcl-2 and Bax expression, induced by loss of attachment, and inhibited by specific extracellular matrix proteins in mammary epithelial cells. Cell Growth Differ 1997;8:251-260.
34. Wallon G, Buttyan R, Garcia-Montes E, Olsson CA, Hensle TW, Sawezuk IS: Renal growth factor expression during the early phase of experimental hydronephrosis. J Urol 1992; 148:510-514.
35. Oberhammer F, Bursch W, Tiefenbacher R, Froeschl G, Pavelka M, Purchio T, Schulte-Hermann R: Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology 1993;18:1238-1246.
36. Tsukada T, Eguchi K, Migita K, Kawabe Y, Kawakami A, Matsuoka N, Takashima H, Mizokami A, Nagataki S: Transforming growth factor beta 1 induces apoptotic cell death in cultured human umbilical vein endothelial cells with downregulaled expression of bcl-2. Biochem Biophys Res Commun 1995;210: 1076-1082.
37. Selvakumaran M, Lin H-K, Sjin RTT, Reed JC, Liebermann DA, Hoffman B: The novel primary response gene MyD118 and the protooncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells. Mol Cell Biol 1994;14:2352-2360.
38. Ortiz A, Neilson EG: Expression of bax and bcl-x members of the bcl-2 gene family in niurinc jugular cells and acute renal failure (abstract). J Am Soc Nephrol 1994;5:906.
39. Chevalier RL, Kim A, Thornhill BA, Wolstenholme JT: Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Kidney Int 1999;55:793-807.
40. Camp V, Martin P: The role of macrophages in clearing programmed cell death in the developing kidney. Anat Embryol (Berl) 1996;194: 341-348.
41. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993;75:229-240.
42. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR: Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficicnt mice. Am J Physiol 1995; 268:F73-F81.
43. Fetterman GH, Ravitch MM, Sherman FE: Cystic changes in fetal kidneys following ureteral ligation: Studies by microdissection. Kidney Int 1974;5:111-121.
44. Gattone VH, Andrews GK, Niu FW, Chadwick LJ, Klein RM, Calvet JP: Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Dev Biol 1990; 138:225-230.
45. Woo D: Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 1995; 333:18-25.
46. EI-Dahr SS, Gomez RA, Gray MS, Peach MJ, Carey RM, Chevalier RL: In situ localization of renin and its mRNA in neonatal ureteral obstruction. Am J Physiol 1990;258:F854-F862.
47. Graham PC, Lindop GBM: The anatomy of the renin-secreting cell in adult polycystic kidney disease. Kidney Int 1988;33:1084-1090.
48. Leri A, Claudio PP, Li Q, Wang XW, Reiss K, Wang SG, Malhotra A, Kajstura J, Anversa P: Stretch-mediated release of angiotensin II induces myocytc apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the bcl-2-to-bax protein ratio in the cell. J Clin Invest 1998;101:1326-1342.